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| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (117 aa) |
| | Tsac_0028 | KEGG: txy:Thexy_1925 aconitate hydratase; TIGRFAM: Aconitase, putative; 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (640 aa) |
| | Tsac_0033 | KEGG: txy:Thexy_1930 hypothetical protein. (316 aa) |
| | Tsac_0045 | KEGG: txy:Thexy_1942 hypothetical protein. (622 aa) |
| | Tsac_0060 | PFAM: Aminotransferase, class I/II; KEGG: txy:Thexy_1957 aminotransferase class I and II. (349 aa) |
| | cobD | Cobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (318 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (308 aa) |
| | Tsac_0162 | PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain; KEGG: txy:Thexy_2048 altronate dehydratase. (496 aa) |
| | Tsac_0224 | PFAM: Dehydratase, small subunit; KEGG: txy:Thexy_2099 dehydratase small subunit. (132 aa) |
| | Tsac_0225 | PFAM: Dehydratase, medium subunit; KEGG: txy:Thexy_2100 dehydratase medium subunit. (208 aa) |
| | Tsac_0226 | PFAM: Diol/glycerol dehydratase, large subunit; KEGG: txy:Thexy_2101 glycerol dehydratase. (554 aa) |
| | Tsac_0227 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: txy:Thexy_2102 class II aldolase/adducin family protein. (259 aa) |
| | Tsac_0230 | PFAM: Streptococcal 67kDa myosin-cross-reactive antigen like; KEGG: ctc:CTC01855 myosin-cross-reactive antigen. (525 aa) |
| | Tsac_0235 | KEGG: txy:Thexy_2110 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (335 aa) |
| | Tsac_0260 | KEGG: hor:Hore_18020 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (282 aa) |
| | Tsac_0268 | KEGG: txy:Thexy_2143 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; TIGRFAM: KDPG/KHG aldolase; PFAM: KDPG/KHG aldolase. (206 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | Tsac_0328 | KEGG: txy:Thexy_2204 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (283 aa) |
| | Tsac_0375 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa) |
| | Tsac_0396 | Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (408 aa) |
| | Tsac_0414 | KEGG: txy:Thexy_2314 DNA repair photolyase-like protein protein. (325 aa) |
| | Tsac_0539 | KEGG: txy:Thexy_2402 cysteine desulfurase family protein; TIGRFAM: Cysteine desulfurase-related, unknown function; PFAM: Aminotransferase, class V/Cysteine desulfurase. (381 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | ilvD | TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: txy:Thexy_0018 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | ribBA | GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (396 aa) |
| | Tsac_0628 | KEGG: txy:Thexy_0062 formate acetyltransferase; TIGRFAM: Formate acetyltransferase; PFAM: Pyruvate formate-lyase, PFL; Formate C-acetyltransferase glycine radical. (742 aa) |
| | Tsac_0631 | KEGG: txy:Thexy_0066 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region. (280 aa) |
| | Tsac_0632 | KEGG: txy:Thexy_0067 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; TIGRFAM: Fe-S type hydro-lyases tartrate/fumarate beta region; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region. (185 aa) |
| | Tsac_0680 | PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: txy:Thexy_0111 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (118 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | Tsac_0783 | PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: txy:Thexy_0185 Threonine aldolase. (345 aa) |
| | argH | TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: txy:Thexy_0209 argininosuccinate lyase; PFAM: Fumarate lyase. (440 aa) |
| | Tsac_0815 | PFAM: Fumarate lyase; Fumarase C, C-terminal; KEGG: txy:Thexy_0216 aspartate ammonia-lyase. (471 aa) |
| | Tsac_0839 | AIG2 family protein; PFAM: AIG2-like; KEGG: tam:Theam_0546 AIG2 family protein. (148 aa) |
| | Tsac_0945 | PFAM: Biotin/lipoyl attachment; KEGG: txy:Thexy_0267 biotin/lipoyl attachment domain-containing protein. (127 aa) |
| | Tsac_0960 | KEGG: txy:Thexy_0282 queuosine biosynthesis protein QueD; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. (123 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | dacA | Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (277 aa) |
| | Tsac_1135 | Protein of unknown function UPF0047; KEGG: txy:Thexy_0413 hypothetical protein; TIGRFAM: Uncharacterised protein family UPF0047; PFAM: Uncharacterised protein family UPF0047. (128 aa) |
| | nnrE | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (508 aa) |
| | hisB | KEGG: txy:Thexy_0448 imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | Tsac_1214 | KEGG: txy:Thexy_0491 hypothetical protein. (525 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (445 aa) |
| | Tsac_1352 | KEGG: txy:Thexy_0624 hypothetical protein. (356 aa) |
| | Tsac_1394 | PFAM: Xylose isomerase, TIM barrel domain; KEGG: txy:Thexy_1845 xylose isomerase. (265 aa) |
| | pdxS | Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (357 aa) |
| | Tsac_1493 | PFAM: Protein of unknown function DUF111; KEGG: tbo:Thebr_1574 hypothetical protein. (243 aa) |
| | Tsac_1494 | PFAM: Protein of unknown function DUF111; KEGG: thx:Thet_0717 hypothetical protein. (131 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | Tsac_1614 | KEGG: txy:Thexy_1107 L-serine dehydratase, iron-sulfur-dependent, beta subunit; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase beta subunit; PFAM: Serine dehydratase beta chain; Amino acid-binding ACT. (227 aa) |
| | Tsac_1615 | KEGG: txy:Thexy_1108 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; TIGRFAM: L-serine dehydratase, alpha subunit; PFAM: Serine dehydratase alpha chain. (291 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | pheA | PFAM: Prephenate dehydratase; Amino acid-binding ACT; KEGG: txy:Thexy_1110 Prephenate dehydratase. (274 aa) |
| | Tsac_1618 | KEGG: txy:Thexy_1111 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (338 aa) |
| | Tsac_1643 | KEGG: txy:Thexy_1137 radical SAM protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (326 aa) |
| | Tsac_1651 | KEGG: tmt:Tmath_0432 uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase. (496 aa) |
| | Tsac_1653 | TIGRFAM: Sirohaem synthase, N-terminal; KEGG: tbo:Thebr_1936 glutamate-1-semialdehyde-2,1-aminomutase. (195 aa) |
| | Tsac_1654 | Delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; KEGG: tbo:Thebr_1937 Porphobilinogen synthase; Belongs to the ALAD family. (324 aa) |
| | pyrF | TIGRFAM: Orotidine 5'-phosphate decarboxylase, subfamily 2, core; HAMAP: Orotidine 5'-phosphate decarboxylase; KEGG: txy:Thexy_1409 Orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase, core; Belongs to the OMP decarboxylase family. Type 2 subfamily. (306 aa) |
| | Tsac_1717 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | Tsac_1858 | KEGG: txy:Thexy_1255 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. (474 aa) |
| | Tsac_1861 | PFAM: Aluminium resistance; KEGG: txy:Thexy_1252 aluminum resistance family protein. (428 aa) |
| | speH | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (124 aa) |
| | Tsac_1885 | PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; KEGG: txy:Thexy_1228 Pyruvate carboxylase. (464 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (342 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: txy:Thexy_1470 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | Tsac_2014 | KEGG: txy:Thexy_1472 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal. (195 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (217 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa) |
| | Tsac_2092 | AIG2 family protein; PFAM: AIG2-like; KEGG: txy:Thexy_1546 AIG2 family protein. (141 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (131 aa) |
| | Tsac_2164 | Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa) |
| | Tsac_2166 | KEGG: txy:Thexy_1621 methylmalonyl-CoA epimerase; TIGRFAM: Methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (132 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (543 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (348 aa) |
| | Tsac_2241 | KEGG: mzh:Mzhil_1568 Radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (273 aa) |
| | Tsac_2311 | Protein of unknown function UPF0047; PFAM: Uncharacterised protein family UPF0047; KEGG: elm:ELI_4500 hypothetical protein. (173 aa) |
| | Tsac_2313 | Ketose-bisphosphate aldolase; KEGG: elm:ELI_4501 hypothetical protein; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (280 aa) |
| | Tsac_2333 | KEGG: tte:TTE0360 lactoylglutathione lyase and related lyase. (150 aa) |
| | Tsac_2334 | TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic-like; PFAM: Radical SAM; KEGG: txy:Thexy_0928 anaerobic ribonucleoside-triphosphate reductase activating protein; SMART: Elongator protein 3/MiaB/NifB. (227 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa) |
| | Tsac_2522 | PFAM: Radical SAM; KEGG: txy:Thexy_0783 radical SAM protein. (297 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (146 aa) |
| | Tsac_2646 | PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: thx:Thet_0350 cobalamin (vitamin B12) biosynthesis CbiX protein. (121 aa) |
