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| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (211 aa) |
| | glpK-2 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (496 aa) |
| | Tsac_2169 | KEGG: txy:Thexy_1624 methylmalonyl-CoA mutase, large subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic. (559 aa) |
| | Tsac_2241 | KEGG: mzh:Mzhil_1568 Radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (273 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (209 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (266 aa) |
| | Tsac_2276 | PFAM: PglZ domain; KEGG: txy:Thexy_0977 PglZ domain protein. (646 aa) |
| | Tsac_2312 | Triosephosphate isomerase; KEGG: elm:ELI_2469 hypothetical protein; TIGRFAM: Triosephosphate isomerase; PFAM: Triosephosphate isomerase. (235 aa) |
| | Tsac_2313 | Ketose-bisphosphate aldolase; KEGG: elm:ELI_4501 hypothetical protein; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (280 aa) |
| | Tsac_2340 | Protein of unknown function DUF129; PFAM: F420-0:gamma-glutamyl ligase-related; KEGG: txy:Thexy_0922 hypothetical protein. (233 aa) |
| | Tsac_2357 | Beta-lactamase; KEGG: txy:Thexy_0905 beta-lactamase. (272 aa) |
| | Tsac_2390 | KEGG: rci:RCIX210 hypothetical protein. (400 aa) |
| | Tsac_2478 | Deoxyguanosinetriphosphate triphosphohydrolase-like protein; SMART: Metal-dependent phosphohydrolase, HD region; TIGRFAM: Deoxyguanosinetriphosphate triphosphohydrolase; KEGG: txy:Thexy_0822 deoxyguanosinetriphosphate triphosphohydrolase-like protein; HAMAP: Deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; Belongs to the dGTPase family. Type 2 subfamily. (336 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgk | KEGG: txy:Thexy_0815 phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase. (393 aa) |
| | Tsac_2550 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa) |
| | purD | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: txy:Thexy_0715 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (416 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: txy:Thexy_0714 Bifunctional purine biosynthesis protein PurH; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. (508 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (202 aa) |
| | purM | KEGG: txy:Thexy_0712 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (336 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (465 aa) |
| | purC | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: txy:Thexy_0710 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (235 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | Tsac_2625 | KEGG: txy:Thexy_0667 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (314 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (492 aa) |
| | Tsac_1639 | KEGG: txy:Thexy_1132 phosphoribosylformylglycinamidine synthase; TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; PFAM: AIR synthase related protein, C-terminal. (1255 aa) |
| | Tsac_1656 | KEGG: cki:Calkr_1168 thiamine biosynthesis protein this; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS. (69 aa) |
| | Tsac_1657 | PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: cth:Cthe_2539 UBA/ThiF-type NAD/FAD binding fold. (273 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa) |
| | Tsac_1696 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (718 aa) |
| | pyrB | TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: txy:Thexy_1411 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa) |
| | pyrF | TIGRFAM: Orotidine 5'-phosphate decarboxylase, subfamily 2, core; HAMAP: Orotidine 5'-phosphate decarboxylase; KEGG: txy:Thexy_1409 Orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase, core; Belongs to the OMP decarboxylase family. Type 2 subfamily. (306 aa) |
| | pyrK | Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (243 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (301 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (191 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa) |
| | Tsac_1717 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | Tsac_1728 | KEGG: txy:Thexy_1384 ribulose-phosphate 3-epimerase; TIGRFAM: Ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase. (217 aa) |
| | Tsac_1729 | KEGG: txy:Thexy_1383 thiamine pyrophosphokinase; TIGRFAM: Thiamin pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain. (211 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | Tsac_1744 | KEGG: txy:Thexy_1369 phosphate acetyltransferase; TIGRFAM: Phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase. (328 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (333 aa) |
| | Tsac_1784 | TIGRFAM: flagellar protein export ATPase FliI; ATPase, type III secretion system, FliI/YscN; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; KEGG: txy:Thexy_1329 flagellar protein export ATPase FliI; SMART: ATPase, AAA+ type, core. (438 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | Tsac_1817 | PFAM: Phosphatidate cytidylyltransferase; KEGG: txy:Thexy_1296 phosphatidate cytidylyltransferase; Belongs to the CDS family. (260 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (382 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa) |
| | Tsac_1830 | KEGG: txy:Thexy_1282 riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (305 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | Tsac_1844 | KEGG: txy:Thexy_1269 CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (178 aa) |
| | cinA | KEGG: txy:Thexy_1268 competence/damage-inducible protein CinA; TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; Belongs to the CinA family. (414 aa) |
| | Tsac_1858 | KEGG: txy:Thexy_1255 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. (474 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (283 aa) |
| | Tsac_1876 | KEGG: txy:Thexy_1237 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (192 aa) |
| | cmk | TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: txy:Thexy_1236 cytidylate kinase; PFAM: Cytidylate kinase region; Shikimate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily. (256 aa) |
| | Tsac_1880 | PFAM: Phosphoglycerate mutase; KEGG: txy:Thexy_1233 phosphoglycerate mutase. (207 aa) |
| | surE | Survival protein SurE-like phosphatase/nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa) |
| | Tsac_1891 | KEGG: txy:Thexy_1222 hypothetical protein. (322 aa) |
| | Tsac_1916 | PFAM: Thiamin pyrophosphokinase, catalytic domain; KEGG: txy:Thexy_1197 thiamin pyrophosphokinase catalytic domain-containing protein. (373 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (272 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (617 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | Tsac_1994 | PFAM: ATP-grasp fold, DUF201-type; KEGG: gct:GC56T3_1151 hypothetical protein. (418 aa) |
| | Tsac_2004 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (661 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (217 aa) |
| | Tsac_2045 | KEGG: txy:Thexy_1499 diacylglycerol kinase; PFAM: Diacylglycerol kinase, prokaryotic; Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase. (232 aa) |
| | Tsac_2053 | PFAM: Histidine triad (HIT) protein; KEGG: txy:Thexy_1507 histidine triad (HIT) protein. (114 aa) |
| | Tsac_2086 | PFAM: Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; KEGG: txy:Thexy_1544 oxidoreductase FAD/NAD(P)-binding domain protein. (284 aa) |
| | gpsA | KEGG: txy:Thexy_1090 glycerol-3-phosphate dehydrogenase (NAD(P)+); HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal. (330 aa) |
| | Tsac_2102 | Metal dependent phosphohydrolase; TIGRFAM: Conserved hypothetical protein CHP00488; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: txy:Thexy_1556 metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD region. (190 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (207 aa) |
| | Tsac_2124 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (191 aa) |
| | Tsac_2141 | PFAM: Quinolinate phosphoribosyl transferase; KEGG: txy:Thexy_1595 quinolinate phosphoribosyl transferase domain-containing protein. (344 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | plsY-2 | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa) |
| | Tsac_1492 | PFAM: 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: txy:Thexy_1687 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase. (251 aa) |
| | Tsac_1490 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: txy:Thexy_1689 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (171 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (434 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | pdxS | Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (137 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (461 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (285 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (506 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (162 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (218 aa) |
| | pgi | KEGG: txy:Thexy_1846 glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (451 aa) |
| | Tsac_1363 | KEGG: txy:Thexy_0635 pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PEP-utilising enzyme, mobile region. (583 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa) |
| | Tsac_1312 | KEGG: txy:Thexy_0585 isochorismatase hydrolase. (248 aa) |
| | Tsac_1288 | PFAM: 3-dehydroquinate synthase AroB; KEGG: txy:Thexy_0559 glycerol-1-phosphate dehydrogenase (NAD(P)(+)). (428 aa) |
| | araB | TIGRFAM: L-ribulokinase; HAMAP: L-ribulokinase; KEGG: txy:Thexy_0555 ribulokinase; PFAM: Carbohydrate kinase, FGGY, C-terminal; Carbohydrate kinase, FGGY, N-terminal. (564 aa) |
| | Tsac_1283 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (465 aa) |
| | Tsac_1255 | ROK family protein; PFAM: ROK; KEGG: txy:Thexy_0534 glucokinase. (311 aa) |
| | Tsac_0027 | PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: txy:Thexy_1924 metal dependent phosphohydrolase. (196 aa) |
| | Tsac_0033 | KEGG: txy:Thexy_1930 hypothetical protein. (316 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (389 aa) |
| | Tsac_0046 | KEGG: txy:Thexy_1943 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa) |
| | Tsac_0061 | KEGG: txy:Thexy_1958 hypothetical protein. (243 aa) |
| | Tsac_0104 | 5'-Nucleotidase domain-containing protein; KEGG: txy:Thexy_1993 5'-nucleotidase., 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SH3, type 3; SMART: Bacterial SH3-like region. (1208 aa) |
| | Tsac_0154 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (466 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa) |
| | Tsac_0260 | KEGG: hor:Hore_18020 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (282 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | Tsac_0301 | S-layer domain-containing protein; PFAM: S-layer homology region; KEGG: txy:Thexy_2177 S-layer domain-containing protein. (486 aa) |
| | Tsac_0315 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: txy:Thexy_2191 CMP/dCMP deaminase zinc-binding protein. (148 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | tdk | KEGG: txy:Thexy_2200 thymidine kinase; HAMAP: Thymidine kinase, subgroup; PFAM: Thymidine kinase. (192 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | Tsac_0328 | KEGG: txy:Thexy_2204 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (283 aa) |
| | Tsac_0348 | KEGG: txy:Thexy_2229 1-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; PFAM: Carbohydrate/purine kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (310 aa) |
| | Tsac_0358 | KEGG: txy:Thexy_2239 hypothetical protein. (535 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | Tsac_0458 | KEGG: aur:HMPREF9243_0369 hypothetical protein. (227 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (496 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | Tsac_0527 | KEGG: txy:Thexy_2390 hypothetical protein. (98 aa) |
| | Tsac_0537 | TIGRFAM: Conserved hypothetical protein CHP00147; PFAM: Diacylglycerol kinase, catalytic region; KEGG: txy:Thexy_2400 hypothetical protein; SMART: Diacylglycerol kinase, catalytic region. (290 aa) |
| | Tsac_0603 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: syp:SYNPCC7002_E0039 hypothetical protein. (639 aa) |
| | Tsac_0634 | KEGG: txy:Thexy_0070 glucokinase, ROK family; TIGRFAM: Glucokinase ROK; PFAM: ROK. (315 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (205 aa) |
| | Tsac_0705 | KEGG: dae:Dtox_1602 anaerobic sulfite reductase subunit B; TIGRFAM: Sulphite reductase, subunit B; PFAM: Oxidoreductase FAD/NAD(P)-binding; Oxidoreductase FAD-binding region; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain. (263 aa) |
| | glmU | Bifunctional protein glmUg, glucosamine-1-phosphate acetyltransferase, uridyltransferase activity; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa) |
| | Tsac_0750 | PFAM: Acylneuraminate cytidylyltransferase; KEGG: txy:Thexy_0161 acylneuraminate cytidylyltransferase. (240 aa) |
| | Tsac_0770 | KEGG: txy:Thexy_0176 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (329 aa) |
| | carA | KEGG: txy:Thexy_0206 carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (356 aa) |
| | carB | KEGG: txy:Thexy_0207 carbamoyl-phosphate synthase, large subunit; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like. (1073 aa) |
| | Tsac_0819 | KEGG: txy:Thexy_0220 MazG family protein; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; Tetrapyrrole methylase. (495 aa) |
| | Tsac_0915 | KEGG: txy:Thexy_0241 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa) |
| | Tsac_0936 | KEGG: txy:Thexy_0258 hypoxanthine phosphoribosyltransferase; TIGRFAM: Hypoxanthine phosphoribosyl transferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa) |
| | folE | TIGRFAM: GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; KEGG: txy:Thexy_0279 GTP cyclohydrolase 1; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (188 aa) |
| | mcsB | Protein arginine kinase, McsB; Catalyzes the specific phosphorylation of arginine residues in proteins. (335 aa) |
| | Tsac_0982 | KEGG: txy:Thexy_0304 hypothetical protein. (131 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (230 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | Tsac_1050 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (505 aa) |
| | Tsac_1051 | PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; KEGG: txy:Thexy_0374 MazG nucleotide pyrophosphohydrolase. (104 aa) |
| | dacA | Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (277 aa) |
| | Tsac_1068 | KEGG: txy:Thexy_0391 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (203 aa) |
| | Tsac_1119 | PFAM: Nucleoside phosphorylase; KEGG: cpo:COPRO5265_1476 uridine phosphorylase (UrdPase) (UPase). (246 aa) |
| | nnrE | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (508 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | Tsac_1151 | KEGG: txy:Thexy_0431 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (276 aa) |
