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| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (117 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (405 aa) |
| | Tsac_0029 | KEGG: txy:Thexy_1926 homocitrate synthase; TIGRFAM: Homocitrate synthase NifV-type; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa) |
| | Tsac_0044 | KEGG: txy:Thexy_1941 glutamate formiminotransferase; TIGRFAM: Formiminotransferase; PFAM: Formiminotransferase, N-terminal; Formiminotransferase, C-terminal. (298 aa) |
| | Tsac_0046 | KEGG: txy:Thexy_1943 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa) |
| | Tsac_0047 | KEGG: txy:Thexy_1944 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, eukaryotic; PFAM: Isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (308 aa) |
| | leuS | KEGG: txy:Thexy_2006 leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (814 aa) |
| | Tsac_0154 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (466 aa) |
| | Tsac_0156 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: txy:Thexy_2042 D-lactate dehydrogenase. (326 aa) |
| | Tsac_0162 | PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain; KEGG: txy:Thexy_2048 altronate dehydratase. (496 aa) |
| | uxaC | KEGG: txy:Thexy_2056 Uronate isomerase; HAMAP: Uronate isomerase; PFAM: Uronate isomerase. (466 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa) |
| | Tsac_0218 | PFAM: Alcohol dehydrogenase, zinc-binding; Alcohol dehydrogenase GroES-like; KEGG: txy:Thexy_2094 L-iditol 2-dehydrogenase. (403 aa) |
| | Tsac_0230 | PFAM: Streptococcal 67kDa myosin-cross-reactive antigen like; KEGG: ctc:CTC01855 myosin-cross-reactive antigen. (525 aa) |
| | Tsac_0234 | Fumarylacetoacetate (FAA) hydrolase; PFAM: Fumarylacetoacetase, C-terminal-like; KEGG: txy:Thexy_2108 5-carboxymethyl-2-hydroxymuconate Delta-isomerase. (242 aa) |
| | Tsac_0235 | KEGG: txy:Thexy_2110 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (335 aa) |
| | Tsac_0248 | PFAM: Vitamin B12 dependent methionine synthase, activation region; KEGG: txy:Thexy_2122 Vitamin B12 dependent methionine synthase activation region. (827 aa) |
| | Tsac_0260 | KEGG: hor:Hore_18020 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (282 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa) |
| | Tsac_0328 | KEGG: txy:Thexy_2204 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: Fructose-1,6-bisphosphate aldolase, class II; Ketose-bisphosphate aldolase, class-II; PFAM: Ketose-bisphosphate aldolase, class-II. (283 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | Tsac_0367 | KEGG: txy:Thexy_2251 histidinol phosphate phosphatase HisJ family; TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP, C-terminal; Belongs to the PHP hydrolase family. HisK subfamily. (272 aa) |
| | Tsac_0370 | KEGG: txy:Thexy_2256 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT. (533 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa) |
| | Tsac_0375 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa) |
| | Tsac_0376 | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: txy:Thexy_2263 homoserine dehydrogenase. (419 aa) |
| | Tsac_0381 | KEGG: txy:Thexy_2268 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (282 aa) |
| | Tsac_0396 | Cysteine desulfurase, SufS subfamily; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (408 aa) |
| | Tsac_0539 | KEGG: txy:Thexy_2402 cysteine desulfurase family protein; TIGRFAM: Cysteine desulfurase-related, unknown function; PFAM: Aminotransferase, class V/Cysteine desulfurase. (381 aa) |
| | Tsac_0557 | PFAM: CobB/CobQ-like glutamine amidotransferase; KEGG: txy:Thexy_0006 CobB/CobQ domain protein glutamine amidotransferase. (244 aa) |
| | Tsac_0563 | KEGG: txy:Thexy_0012 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (161 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | Tsac_0565 | PFAM: Pyruvate carboxyltransferase; KEGG: txy:Thexy_0014 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | ilvD | TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: txy:Thexy_0018 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | Tsac_0570 | KEGG: txy:Thexy_0019 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (551 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | Tsac_0634 | KEGG: txy:Thexy_0070 glucokinase, ROK family; TIGRFAM: Glucokinase ROK; PFAM: ROK. (315 aa) |
| | arcA | PFAM: Amidinotransferase; KEGG: txy:Thexy_0082 arginine deiminase. (406 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (636 aa) |
| | Tsac_0676 | PFAM: NADH:ubiquinone oxidoreductase, subunit 1; KEGG: txy:Thexy_0107 respiratory-chain NADH dehydrogenase subunit 1. (287 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (162 aa) |
| | arcA-2 | TIGRFAM: Arginine deiminase; HAMAP: Arginine deiminase; KEGG: txy:Thexy_0173 arginine deiminase; PFAM: Amidinotransferase. (415 aa) |
| | Tsac_0768 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (329 aa) |
| | Tsac_0770 | KEGG: txy:Thexy_0176 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (329 aa) |
| | argR-2 | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (149 aa) |
| | argS | TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic; KEGG: txy:Thexy_0180 arginyl-tRNA synthetase. (562 aa) |
| | Tsac_0775 | KEGG: txy:Thexy_0181 Zn-dependent hydrolase of the beta-lactamase fold-like protein protein. (213 aa) |
| | Tsac_0783 | PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: txy:Thexy_0185 Threonine aldolase. (345 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | N-acetylglutamate synthase (N-acetylornithine aminotransferase); Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | argD | TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: txy:Thexy_0205 acetylornithine/succinyldiaminopimelate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa) |
| | carA | KEGG: txy:Thexy_0206 carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (356 aa) |
| | carB | KEGG: txy:Thexy_0207 carbamoyl-phosphate synthase, large subunit; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like. (1073 aa) |
| | argG | TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: txy:Thexy_0208 argininosuccinate synthase; PFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa) |
| | argH | TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: txy:Thexy_0209 argininosuccinate lyase; PFAM: Fumarate lyase. (440 aa) |
| | Tsac_0824 | HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: txy:Thexy_0225 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like; Pyridoxal phosphate phosphatase-related; PFAM: Haloacid dehalogenase-like hydrolase. (213 aa) |
| | Tsac_0915 | KEGG: txy:Thexy_0241 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa) |
| | Tsac_0942 | KEGG: txy:Thexy_0264 hypothetical protein. (121 aa) |
| | Tsac_0943 | PFAM: Carboxyl transferase; KEGG: txy:Thexy_0265 Propionyl-CoA carboxylase. (516 aa) |
| | Tsac_0945 | PFAM: Biotin/lipoyl attachment; KEGG: txy:Thexy_0267 biotin/lipoyl attachment domain-containing protein. (127 aa) |
| | lysS | TIGRFAM: Lysyl-tRNA synthetase, class II; HAMAP: Lysyl-tRNA synthetase; KEGG: txy:Thexy_0278 lysyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; Belongs to the class-II aminoacyl-tRNA synthetase family. (506 aa) |
| | Tsac_0958 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (270 aa) |
| | Tsac_0959 | KEGG: txy:Thexy_0281 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (165 aa) |
| | Tsac_0964 | PFAM: Aminotransferase class-III; KEGG: txy:Thexy_0286 acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (230 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (570 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (487 aa) |
| | Tsac_0990 | TIGRFAM: Serine O-acetyltransferase; KEGG: txy:Thexy_0312 serine O-acetyltransferase. (212 aa) |
| | cysS | KEGG: txy:Thexy_0313 cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; PFAM: Cysteinyl-tRNA synthetase, class Ia, N-terminal; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa) |
| | Tsac_1066 | PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1630 2-oxoglutarate synthase. (249 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | Tsac_1140 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (388 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | Tsac_1151 | KEGG: txy:Thexy_0431 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (276 aa) |
| | Tsac_1162 | KEGG: cpy:Cphy_2269 hypothetical protein. (860 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa) |
| | hisC | TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: txy:Thexy_0447 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | hisB | KEGG: txy:Thexy_0448 imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisA | TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: txy:Thexy_0450 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis. (235 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisI | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; KEGG: txy:Thexy_0452 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (226 aa) |
| | Tsac_1183 | LmbE family protein; PFAM: N-acetylglucosaminyl phosphatidylinositol deacetylase; KEGG: txy:Thexy_0453 LmbE family protein. (474 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | Tsac_1219 | KEGG: txy:Thexy_0496 CoA-substrate-specific enzyme activase; TIGRFAM: CoA enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type. (328 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (445 aa) |
| | Tsac_1231 | PFAM: Glutamate synthase, alpha subunit, C-terminal; KEGG: txy:Thexy_0510 glutamate synthase alpha subunit domain protein. (243 aa) |
| | Tsac_1234 | PFAM: Glutamate synthase, central-C; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: txy:Thexy_0513 glutamate synthase (NADPH). (501 aa) |
| | Tsac_1235 | PFAM: Glutamine amidotransferase, class-II; KEGG: txy:Thexy_0514 glutamine amidotransferase class-II. (374 aa) |
| | Tsac_1255 | ROK family protein; PFAM: ROK; KEGG: txy:Thexy_0534 glucokinase. (311 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | Tsac_1318 | KEGG: txy:Thexy_0591 cysteine synthase A; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (310 aa) |
| | Tsac_1320 | KEGG: txy:Thexy_0603 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (430 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (321 aa) |
| | Tsac_1363 | KEGG: txy:Thexy_0635 pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PEP-utilising enzyme, mobile region. (583 aa) |
| | pgi | KEGG: txy:Thexy_1846 glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (451 aa) |
| | Tsac_1396 | PFAM: Methylenetetrahydrofolate reductase; KEGG: txy:Thexy_1843 methylenetetrahydrofolate reductase. (300 aa) |
| | Tsac_1397 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: txy:Thexy_1842 methionine synthase. (801 aa) |
| | Tsac_1406 | PFAM: Aldo/keto reductase; KEGG: cbt:CLH_1949 morphine 6-dehydrogenase. (281 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | Tsac_1439 | KEGG: txy:Thexy_1751 hypothetical protein. (167 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (357 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (878 aa) |
| | dapH | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (237 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa) |
| | Tsac_1554 | PFAM: Aminotransferase, class V/Cysteine desulfurase; KEGG: txy:Thexy_1049 Cysteine desulfurase. (384 aa) |
| | Tsac_1611 | Cyclase family protein; PFAM: Putative cyclase; KEGG: txy:Thexy_1104 cyclase family protein. (209 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | pheA | PFAM: Prephenate dehydratase; Amino acid-binding ACT; KEGG: txy:Thexy_1110 Prephenate dehydratase. (274 aa) |
| | Tsac_1618 | KEGG: txy:Thexy_1111 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (338 aa) |
| | Tsac_1619 | PFAM: Prephenate dehydrogenase; KEGG: txy:Thexy_1112 Prephenate dehydrogenase. (281 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (256 aa) |
| | Tsac_1660 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: sgy:Sgly_0513 cysteine synthase. (408 aa) |
| | Tsac_1665 | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. (242 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | pyrB | TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: txy:Thexy_1411 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | Tsac_1717 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | fapR | Transcription factor fapR; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (196 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (333 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (333 aa) |
| | Tsac_1752 | KEGG: txy:Thexy_1361 malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (310 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa) |
| | Tsac_1755 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (409 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (327 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (382 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa) |
| | Tsac_1839 | KEGG: txy:Thexy_1274 aspartate kinase; TIGRFAM: Aspartate kinase region; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (412 aa) |
| | asnS | TIGRFAM: Asparaginyl-tRNA synthetase, class IIb; HAMAP: Asparaginyl-tRNA synthetase; KEGG: txy:Thexy_1254 asparaginyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type. (431 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (283 aa) |
| | Tsac_1879 | KEGG: txy:Thexy_1234 HI0933 family protein; TIGRFAM: HI0933-like protein; PFAM: HI0933-like protein. (405 aa) |
| | Tsac_1888 | PFAM: GCN5-related N-acetyltransferase; KEGG: txy:Thexy_1225 GCN5-related N-acetyltransferase. (125 aa) |
| | argR-3 | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (150 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (364 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (283 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (877 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (393 aa) |
| | Tsac_1994 | PFAM: ATP-grasp fold, DUF201-type; KEGG: gct:GC56T3_1151 hypothetical protein. (418 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (593 aa) |
| | hisS | TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: txy:Thexy_1458 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Anticodon-binding. (417 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: txy:Thexy_1469 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: txy:Thexy_1470 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | Tsac_2019 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (927 aa) |
| | Tsac_2038 | KEGG: txy:Thexy_1492 pyruvate, phosphate dikinase; TIGRFAM: Pyruvate, phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; PEP-utilising enzyme; Belongs to the PEP-utilizing enzyme family. (876 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (462 aa) |
| | Tsac_2082 | PFAM: Threonyl/alanyl tRNA synthetase, SAD; Alanyl-tRNA synthetase, class IIc, N-terminal; KEGG: txy:Thexy_1536 Threonyl/alanyl tRNA synthetase SAD. (394 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa) |
| | Tsac_2085 | KEGG: txy:Thexy_1543 glutamate synthase (NADPH), homotetrameric; TIGRFAM: Glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region. (463 aa) |
| | gltX-2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (480 aa) |
| | Tsac_2161 | PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1616 2-oxoglutarate synthase. (276 aa) |
| | Tsac_2166 | KEGG: txy:Thexy_1621 methylmalonyl-CoA epimerase; TIGRFAM: Methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (132 aa) |
| | Tsac_2168 | KEGG: txy:Thexy_1623 methylmalonyl-CoA mutase domain protein; TIGRFAM: Methylmalonyl-CoA mutase, C-terminal; PFAM: Cobalamin (vitamin B12)-binding. (132 aa) |
| | Tsac_2171 | PFAM: Asparaginase/glutaminase; KEGG: txy:Thexy_0846 asparaginase. (327 aa) |
| | Tsac_2172 | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; KEGG: txy:Thexy_1625 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (416 aa) |
| | Tsac_2175 | KEGG: txy:Thexy_1627 alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; Belongs to the AlaDH/PNT family. (373 aa) |
| | Tsac_2178 | PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1630 2-oxoglutarate synthase. (249 aa) |
| | Tsac_2182 | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: txy:Thexy_1634 leucine dehydrogenase. (356 aa) |
| | Tsac_2183 | KEGG: txy:Thexy_1635 phosphate butyryltransferase; TIGRFAM: Phosphate butyryltransferase; PFAM: Phosphate acetyl/butaryl transferase. (301 aa) |
| | pheT | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; KEGG: txy:Thexy_1029 phenylalanyl-tRNA synthetase beta chain. (793 aa) |
| | pheS | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain; KEGG: txy:Thexy_1028 phenylalanyl-tRNA synthetase alpha chain; PFAM: Phenylalanyl-tRNA synthetase alpha chain; Phenylalanyl-tRNA synthetase, class II, N-terminal; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (348 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (634 aa) |
| | Tsac_2210 | KEGG: txy:Thexy_1014 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (614 aa) |
| | Tsac_2220 | PFAM: Aminotransferase class-III; KEGG: ckr:CKR_2120 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | Tsac_2232 | KEGG: tbo:Thebr_2145 alanine dehydrogenase; TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; Belongs to the AlaDH/PNT family. (372 aa) |
| | nanE | N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (234 aa) |
| | Tsac_2312 | Triosephosphate isomerase; KEGG: elm:ELI_2469 hypothetical protein; TIGRFAM: Triosephosphate isomerase; PFAM: Triosephosphate isomerase. (235 aa) |
| | Tsac_2333 | KEGG: tte:TTE0360 lactoylglutathione lyase and related lyase. (150 aa) |
| | Tsac_2340 | Protein of unknown function DUF129; PFAM: F420-0:gamma-glutamyl ligase-related; KEGG: txy:Thexy_0922 hypothetical protein. (233 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (366 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | Tsac_2348 | KEGG: txy:Thexy_0913 lipoyltransferase and lipoate-protein ligase; TIGRFAM: Lipoyltransferase/lipoate-protein ligase; PFAM: Lipoate protein ligase, C-terminal; Biotin/lipoate A/B protein ligase. (326 aa) |
| | Tsac_2357 | Beta-lactamase; KEGG: txy:Thexy_0905 beta-lactamase. (272 aa) |
| | Tsac_2375 | LmbE family protein; PFAM: N-acetylglucosaminyl phosphatidylinositol deacetylase; KEGG: txy:Thexy_0870 LmbE family protein. (469 aa) |
| | Tsac_2377 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: txy:Thexy_0868 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (154 aa) |
| | Tsac_2392 | KEGG: mbu:Mbur_1580 asparagine synthase, glutamine-hydrolyzing; TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (638 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgk | KEGG: txy:Thexy_0815 phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase. (393 aa) |
| | Tsac_2508 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; KEGG: txy:Thexy_0793 glyoxylate reductase. (315 aa) |
| | Tsac_2529 | KEGG: txy:Thexy_0776 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa) |
| | Tsac_2535 | PFAM: FMN-dependent dehydrogenase; KEGG: txy:Thexy_0774 (S)-2-hydroxy-acid oxidase. (338 aa) |
| | Tsac_2575 | Amidohydrolase; KEGG: txy:Thexy_0717 amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (411 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (465 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | Tsac_2625 | KEGG: txy:Thexy_0667 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (314 aa) |
| | Tsac_2626 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | Tsac_2627 | PFAM: Amidohydrolase 1; KEGG: txy:Thexy_0665 amidohydrolase. (385 aa) |
| | Tsac_2667 | TIGRFAM: Sialic acid O-acyltransferase, NeuD; KEGG: txy:Thexy_1875 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (220 aa) |
