STRINGSTRING
Tsac_0313 Tsac_0313 Tsac_2672 Tsac_2672 Tsac_2669 Tsac_2669 Tsac_2390 Tsac_2390 Tsac_2348 Tsac_2348 Tsac_2183 Tsac_2183 Tsac_2045 Tsac_2045 Tsac_1995 Tsac_1995 Tsac_1994 Tsac_1994 Tsac_1925 Tsac_1925 dxs dxs Tsac_1876 Tsac_1876 ispH ispH Tsac_1844 Tsac_1844 ispG ispG dxr dxr Tsac_1817 Tsac_1817 Tsac_1816 Tsac_1816 Tsac_1755 Tsac_1755 acpP acpP Tsac_1752 Tsac_1752 fabH fabH plsX plsX fapR fapR gpsA gpsA plsY-2 plsY-2 murG murG Tsac_1531 Tsac_1531 Tsac_1490 Tsac_1490 Tsac_1477 Tsac_1477 Tsac_1439 Tsac_1439 Tsac_1406 Tsac_1406 Tsac_1313 Tsac_1313 Tsac_1288 Tsac_1288 plsY plsY Tsac_1068 Tsac_1068 ispF ispF ispD ispD Tsac_0945 Tsac_0945 Tsac_0943 Tsac_0943 Tsac_0878 Tsac_0878 Tsac_0789 Tsac_0789 ispE ispE glmU glmU Tsac_0537 Tsac_0537 Tsac_0458 Tsac_0458 Tsac_0358 Tsac_0358 Tsac_0357 Tsac_0357 Tsac_0351 Tsac_0351 fabZ fabZ Tsac_0230 Tsac_0230 Tsac_0191 Tsac_0191
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tsac_0313KEGG: txy:Thexy_2189 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase. (383 aa)
Tsac_2672PFAM: Protein of unknown function DUF115; KEGG: txy:Thexy_1882 hypothetical protein. (589 aa)
Tsac_2669KEGG: tit:Thit_0480 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase,UDP-hydrolysing; PFAM: UDP-N-acetylglucosamine 2-epimerase. (384 aa)
Tsac_2390KEGG: rci:RCIX210 hypothetical protein. (400 aa)
Tsac_2348KEGG: txy:Thexy_0913 lipoyltransferase and lipoate-protein ligase; TIGRFAM: Lipoyltransferase/lipoate-protein ligase; PFAM: Lipoate protein ligase, C-terminal; Biotin/lipoate A/B protein ligase. (326 aa)
Tsac_2183KEGG: txy:Thexy_1635 phosphate butyryltransferase; TIGRFAM: Phosphate butyryltransferase; PFAM: Phosphate acetyl/butaryl transferase. (301 aa)
Tsac_2045KEGG: txy:Thexy_1499 diacylglycerol kinase; PFAM: Diacylglycerol kinase, prokaryotic; Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase. (232 aa)
Tsac_1995PFAM: Di-trans-poly-cis-decaprenylcistransferase-like; KEGG: txy:Thexy_1453 Di-trans,poly-cis-decaprenylcistransferase. (216 aa)
Tsac_1994PFAM: ATP-grasp fold, DUF201-type; KEGG: gct:GC56T3_1151 hypothetical protein. (418 aa)
Tsac_1925PFAM: Polyprenyl synthetase; KEGG: txy:Thexy_1188 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (293 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (617 aa)
Tsac_1876KEGG: txy:Thexy_1237 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (192 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (283 aa)
Tsac_1844KEGG: txy:Thexy_1269 CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (178 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (382 aa)
Tsac_1817PFAM: Phosphatidate cytidylyltransferase; KEGG: txy:Thexy_1296 phosphatidate cytidylyltransferase; Belongs to the CDS family. (260 aa)
Tsac_1816Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (253 aa)
Tsac_17553-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (409 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa)
Tsac_1752KEGG: txy:Thexy_1361 malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (310 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (333 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (333 aa)
fapRTranscription factor fapR; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (196 aa)
gpsAKEGG: txy:Thexy_1090 glycerol-3-phosphate dehydrogenase (NAD(P)+); HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal. (330 aa)
plsY-2Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (364 aa)
Tsac_1531PFAM: Polyprenyl synthetase; KEGG: txy:Thexy_1649 trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family. (319 aa)
Tsac_1490PFAM: CDP-alcohol phosphatidyltransferase; KEGG: txy:Thexy_1689 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (171 aa)
Tsac_1477PFAM: Lipopolysaccharide biosynthesis; KEGG: tmt:Tmath_0767 lipopolysaccharide biosynthesis protein. (312 aa)
Tsac_1439KEGG: txy:Thexy_1751 hypothetical protein. (167 aa)
Tsac_1406PFAM: Aldo/keto reductase; KEGG: cbt:CLH_1949 morphine 6-dehydrogenase. (281 aa)
Tsac_1313PFAM: Acyltransferase 3; KEGG: txy:Thexy_0586 acyltransferase 3. (635 aa)
Tsac_1288PFAM: 3-dehydroquinate synthase AroB; KEGG: txy:Thexy_0559 glycerol-1-phosphate dehydrogenase (NAD(P)(+)). (428 aa)
plsYGlycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (211 aa)
Tsac_1068KEGG: txy:Thexy_0391 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (203 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (230 aa)
Tsac_0945PFAM: Biotin/lipoyl attachment; KEGG: txy:Thexy_0267 biotin/lipoyl attachment domain-containing protein. (127 aa)
Tsac_0943PFAM: Carboxyl transferase; KEGG: txy:Thexy_0265 Propionyl-CoA carboxylase. (516 aa)
Tsac_0878S-layer domain-containing protein; PFAM: S-layer homology region; KEGG: tte:TTE2087 S-layer-like domain-containing protein. (487 aa)
Tsac_0789PFAM: Monogalactosyldiacylglycerol synthase; Glycosyl transferase, group 1; KEGG: txy:Thexy_0191 monogalactosyldiacylglycerol synthase. (371 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (288 aa)
glmUBifunctional protein glmUg, glucosamine-1-phosphate acetyltransferase, uridyltransferase activity; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa)
Tsac_0537TIGRFAM: Conserved hypothetical protein CHP00147; PFAM: Diacylglycerol kinase, catalytic region; KEGG: txy:Thexy_2400 hypothetical protein; SMART: Diacylglycerol kinase, catalytic region. (290 aa)
Tsac_0458KEGG: aur:HMPREF9243_0369 hypothetical protein. (227 aa)
Tsac_0358KEGG: txy:Thexy_2239 hypothetical protein. (535 aa)
Tsac_0357PFAM: Glycosyl transferase, family 39; KEGG: txy:Thexy_2238 glycosyl transferase family 39. (721 aa)
Tsac_0351KEGG: txy:Thexy_2232 oligosaccharyl transferase STT3 subunit. (394 aa)
fabZ(3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (143 aa)
Tsac_0230PFAM: Streptococcal 67kDa myosin-cross-reactive antigen like; KEGG: ctc:CTC01855 myosin-cross-reactive antigen. (525 aa)
Tsac_0191KEGG: txy:Thexy_2065 cellulose biosynthesis protein. (370 aa)
Your Current Organism:
Thermoanaerobacterium saccharolyticum
NCBI taxonomy Id: 1094508
Other names: T. saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum str. JW/SL-YS485, Thermoanaerobacterium saccharolyticum strain JW/SL-YS485, Thermoanaerobacterium sp. (strain JW/SL YS485)
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