(67 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Hyaloscypha bicolor)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	A0A2J6SF73	Acetyl-CoA synthetase-like protein. (1023 aa)
	A0A2J6TP78	Prolyl oligopeptidase-like protein. (302 aa)
	A0A2J6TSM7	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (418 aa)
	A0A2J6TTR7	Putative phenylacetyl-CoA ligase. (515 aa)
	A0A2J6TWA9	4-coumarate-CoA ligase-like protein. (552 aa)
	A0A2J6TD10	Peptidase S53 domain-containing protein. (493 aa)
	A0A2J6TCS2	3-dehydroshikimate dehydratase. (592 aa)
	A0A2J6TCM9	PLP-dependent transferase. (502 aa)
	A0A2J6TAX9	Acetyl-CoA synthetase-like protein. (1237 aa)
	A0A2J6TA95	FAD_binding_3 domain-containing protein. (578 aa)
	A0A2J6T994	Subtilisin-like protein. (597 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (281 aa)
	A0A2J6T739	S-adenosyl-L-methionine-dependent methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (332 aa)
	A0A2J6T720	PLP-dependent transferase. (383 aa)
	A0A2J6T6V0	Acetyl-CoA synthetase-like protein. (585 aa)
	A0A2J6T6D2	FAD/NAD(P)-binding domain-containing protein. (631 aa)
	A0A2J6T5Y3	FAD_binding_3 domain-containing protein. (606 aa)
	A0A2J6T489	FAD/NAD(P)-binding domain-containing protein. (410 aa)
	A0A2J6T439	Uncharacterized protein. (252 aa)
	A0A2J6T420	S-adenosyl-L-methionine-dependent methyltransferase. (259 aa)
	A0A2J6T3L5	S-adenosyl-L-methionine-dependent methyltransferase. (295 aa)
	A0A2J6T377	Alpha/beta-hydrolase. (327 aa)
	A0A2J6T2Y5	Para-nitrophenol 4-monooxygenase. (348 aa)
	A0A2J6T2N4	FAD_binding_3 domain-containing protein. (531 aa)
	A0A2J6T2F8	Uncharacterized protein. (637 aa)
	A0A2J6T283	Thioesterase superfamily protein-like protein. (155 aa)
	A0A2J6T282	Uncharacterized protein. (241 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (272 aa)
	A0A2J6T1W4	Thioesterase/thiol ester dehydrase-isomerase. (147 aa)
	A0A2J6T004	4-hydroxyphenylpyruvate dioxygenase. (419 aa)
	A0A2J6T000	Thioesterase/thiol ester dehydrase-isomerase. (186 aa)
	A0A2J6SZ58	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (246 aa)
	A0A2J6SY42	AMP-binding enzyme. (557 aa)
	A0A2J6SXX3	Acyl-coenzyme A thioesteras-like protein 13. (159 aa)
	A0A2J6SWW2	Uncharacterized protein. (549 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (310 aa)
	A0A2J6SV03	S-adenosyl-L-methionine-dependent methyltransferase. (251 aa)
	A0A2J6SUV5	4-coumarate-CoA ligase-like protein. (563 aa)
	A0A2J6STS1	Xylose isomerase-like protein. (368 aa)
	A0A2J6STE1	Acetyl-CoA synthetase-like protein. (545 aa)
	A0A2J6ST85	Peptidase S53 domain-containing protein. (519 aa)
	A0A2J6SQG4	FAD binding domain-containing protein. (624 aa)
	A0A2J6SQC8	Acetyl-CoA synthetase-like protein. (1616 aa)
	A0A2J6SPY5	4HBT domain-containing protein. (166 aa)
	A0A2J6SPF2	FAD-binding domain-containing protein; Belongs to the oxygen-dependent FAD-linked oxidoreductase family. (516 aa)
	A0A2J6SNE1	Acetyl-CoA synthetase-like protein. (553 aa)
	A0A2J6SLT6	Benzoquinone reductase. (203 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (496 aa)
	A0A2J6SLK8	PLP-dependent transferase. (535 aa)
	A0A2J6SL76	FAD/NAD(P)-binding domain-containing protein. (402 aa)
	A0A2J6SJF3	4-coumarate-CoA ligase. (578 aa)
	A0A2J6SJ38	Acetyl-CoA synthetase-like protein. (547 aa)
	A0A2J6SIN3	4-coumarate-CoA ligase 2. (559 aa)
	A0A2J6SHQ9	Thioesterase/thiol ester dehydrase-isomerase. (182 aa)
	A0A2J6SH89	2-succinylbenzoate-CoA ligase. (911 aa)
	A0A2J6SH54	Putative non-ribosomal peptide synthase-like protein. (948 aa)
	A0A2J6TP40	Thioesterase/thiol ester dehydrase-isomerase. (141 aa)
	A0A2J6TNG1	Uncharacterized protein. (214 aa)
	A0A2J6TNA2	FAD/NAD(P)-binding domain-containing protein. (423 aa)
	A0A2J6TMV5	Acetyl-CoA synthetase-like protein. (1129 aa)
	A0A2J6TLB1	Acetyl-CoA synthetase-like protein. (1101 aa)
	A0A2J6TKY1	FAD/NAD(P)-binding domain-containing protein. (630 aa)
	A0A2J6TK24	S-adenosyl-L-methionine-dependent methyltransferase. (369 aa)
	A0A2J6TGZ3	FAD/NAD(P)-binding domain-containing protein. (419 aa)
	A0A2J6TDX3	3-demethylubiquinone-9 3-methyltransferase. (163 aa)
	A0A2J6TDM8	S-adenosyl-L-methionine-dependent methyltransferase. (249 aa)
	A0A2J6TDG9	Acetyl-CoA synthetase-like protein. (568 aa)

Your Current Organism:

Hyaloscypha bicolor

NCBI taxonomy Id: 1095630
Other names: H. bicolor E, Hyaloscypha bicolor E

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A2J6SHQ9	A0A2J6T282	A0A2J6SHQ9	A0A2J6T282	Thioesterase/thiol ester dehydrase-isomerase.	Uncharacterized protein.	0.555
A0A2J6SHQ9	A0A2J6T283	A0A2J6SHQ9	A0A2J6T283	Thioesterase/thiol ester dehydrase-isomerase.	Thioesterase superfamily protein-like protein.	0.555
A0A2J6SJ38	A0A2J6STE1	A0A2J6SJ38	A0A2J6STE1	Acetyl-CoA synthetase-like protein.	Acetyl-CoA synthetase-like protein.	0.464
A0A2J6SJ38	A0A2J6SUV5	A0A2J6SJ38	A0A2J6SUV5	Acetyl-CoA synthetase-like protein.	4-coumarate-CoA ligase-like protein.	0.608
A0A2J6SJ38	A0A2J6TTR7	A0A2J6SJ38	A0A2J6TTR7	Acetyl-CoA synthetase-like protein.	Putative phenylacetyl-CoA ligase.	0.469
A0A2J6SJF3	A0A2J6STE1	A0A2J6SJF3	A0A2J6STE1	4-coumarate-CoA ligase.	Acetyl-CoA synthetase-like protein.	0.495
A0A2J6SJF3	A0A2J6SUV5	A0A2J6SJF3	A0A2J6SUV5	4-coumarate-CoA ligase.	4-coumarate-CoA ligase-like protein.	0.619
A0A2J6SJF3	A0A2J6TTR7	A0A2J6SJF3	A0A2J6TTR7	4-coumarate-CoA ligase.	Putative phenylacetyl-CoA ligase.	0.506
A0A2J6SL76	A0A2J6SV03	A0A2J6SL76	A0A2J6SV03	FAD/NAD(P)-binding domain-containing protein.	S-adenosyl-L-methionine-dependent methyltransferase.	0.471
A0A2J6SL76	A0A2J6T420	A0A2J6SL76	A0A2J6T420	FAD/NAD(P)-binding domain-containing protein.	S-adenosyl-L-methionine-dependent methyltransferase.	0.471
A0A2J6SL76	A0A2J6T439	A0A2J6SL76	A0A2J6T439	FAD/NAD(P)-binding domain-containing protein.	Uncharacterized protein.	0.471
A0A2J6SL76	A0A2J6TK24	A0A2J6SL76	A0A2J6TK24	FAD/NAD(P)-binding domain-containing protein.	S-adenosyl-L-methionine-dependent methyltransferase.	0.471
A0A2J6SL76	A0A2J6TNG1	A0A2J6SL76	A0A2J6TNG1	FAD/NAD(P)-binding domain-containing protein.	Uncharacterized protein.	0.471
A0A2J6SL76	COQ3	A0A2J6SL76	A0A2J6T7D6	FAD/NAD(P)-binding domain-containing protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.471
A0A2J6SLK8	A0A2J6STS1	A0A2J6SLK8	A0A2J6STS1	PLP-dependent transferase.	Xylose isomerase-like protein.	0.755
A0A2J6SLK8	A0A2J6T004	A0A2J6SLK8	A0A2J6T004	PLP-dependent transferase.	4-hydroxyphenylpyruvate dioxygenase.	0.849
A0A2J6SLK8	A0A2J6T720	A0A2J6SLK8	A0A2J6T720	PLP-dependent transferase.	PLP-dependent transferase.	0.465
A0A2J6SLK8	A0A2J6TCS2	A0A2J6SLK8	A0A2J6TCS2	PLP-dependent transferase.	3-dehydroshikimate dehydratase.	0.615
A0A2J6SNE1	A0A2J6STE1	A0A2J6SNE1	A0A2J6STE1	Acetyl-CoA synthetase-like protein.	Acetyl-CoA synthetase-like protein.	0.665
A0A2J6SNE1	A0A2J6SUV5	A0A2J6SNE1	A0A2J6SUV5	Acetyl-CoA synthetase-like protein.	4-coumarate-CoA ligase-like protein.	0.822