STRINGSTRING
ALL80069.1 ALL80069.1 ALL80075.1 ALL80075.1 pfkA pfkA ALL84128.1 ALL84128.1 ALL84129.1 ALL84129.1 ALL84130.1 ALL84130.1 ALL80085.1 ALL80085.1 ALL80094.1 ALL80094.1 ALL80137.1 ALL80137.1 argH argH ALL80154.1 ALL80154.1 argD argD argB argB argJ argJ argC argC ALL84166.1 ALL84166.1 ALL80225.1 ALL80225.1 ALL80234.1 ALL80234.1 ALL84169.1 ALL84169.1 ALL80297.1 ALL80297.1 ALL80337.1 ALL80337.1 ALL80360.1 ALL80360.1 trpC trpC trpE trpE hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD-3 hisD-3 ALL80427.1 ALL80427.1 ALL80436.1 ALL80436.1 ALL80445.1 ALL80445.1 ALL84236.1 ALL84236.1 dapA dapA dapA-2 dapA-2 dapF dapF ALL80772.1 ALL80772.1 dapA-3 dapA-3 ALL84310.1 ALL84310.1 metXA metXA ALL80872.1 ALL80872.1 ALL84364.1 ALL84364.1 ALL84375.1 ALL84375.1 ALL81004.1 ALL81004.1 ALL81023.1 ALL81023.1 glyA glyA ALL81062.1 ALL81062.1 ALL81068.1 ALL81068.1 ALL84401.1 ALL84401.1 ALL81164.1 ALL81164.1 ilvC ilvC ALL81227.1 ALL81227.1 ALL81230.1 ALL81230.1 ALL84436.1 ALL84436.1 ALL81316.1 ALL81316.1 dapD dapD ALL81333.1 ALL81333.1 ALL81367.1 ALL81367.1 ALL81369.1 ALL81369.1 ALL81370.1 ALL81370.1 eno eno prs prs ALL81524.1 ALL81524.1 ALL81526.1 ALL81526.1 serC serC ALL81640.1 ALL81640.1 ALL81647.1 ALL81647.1 asd asd ALL81691.1 ALL81691.1 leuA leuA ALL81714.1 ALL81714.1 trpA trpA trpB trpB pat pat pheA pheA ALL81875.1 ALL81875.1 ALL82049.1 ALL82049.1 aroQ aroQ ALL82114.1 ALL82114.1 pfkA-2 pfkA-2 ALL82235.1 ALL82235.1 metE metE ALL82305.1 ALL82305.1 ALL82309.1 ALL82309.1 gpmA gpmA proC proC argG argG ALL82561.1 ALL82561.1 ALL82572.1 ALL82572.1 ALL82588.1 ALL82588.1 ALL84766.1 ALL84766.1 ALL82621.1 ALL82621.1 ilvA ilvA aroA aroA lysA lysA ALL84795.1 ALL84795.1 ALL84796.1 ALL84796.1 thrB thrB glyA-2 glyA-2 lysA-2 lysA-2 ALL82795.1 ALL82795.1 ilvD ilvD ALL84828.1 ALL84828.1 ALL84829.1 ALL84829.1 ilvC-2 ilvC-2 ALL82821.1 ALL82821.1 leuB leuB leuC leuC leuD leuD ALL82840.1 ALL82840.1 ALL82891.1 ALL82891.1 ALL82934.1 ALL82934.1 trpF trpF gltD gltD ALL84879.1 ALL84879.1 dapA-4 dapA-4 proB proB ALL83101.1 ALL83101.1 trpD trpD ALL83314.1 ALL83314.1 ALL83320.1 ALL83320.1 ALL83492.1 ALL83492.1 ALL83494.1 ALL83494.1 aroC aroC aroK aroK aroB aroB metK metK ALL85013.1 ALL85013.1 ALL83606.1 ALL83606.1 pgk pgk tpiA tpiA trpB-2 trpB-2 tal tal ALL83619.1 ALL83619.1 acnA acnA ALL83846.1 ALL83846.1 metH metH hisE hisE hisG hisG ALL85117.1 ALL85117.1 ALL84014.1 ALL84014.1 ALL84034.1 ALL84034.1 ALL84036.1 ALL84036.1 aroE aroE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALL80069.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
ALL80075.13-hexulose-6-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
pfkADiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (473 aa)
ALL84128.13-hexulose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
ALL84129.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (689 aa)
ALL84130.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
ALL80085.1Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
ALL80094.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (564 aa)
ALL80137.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
ALL80154.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa)
argDAcetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (390 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
ALL84166.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (518 aa)
ALL80225.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (352 aa)
ALL80234.13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
ALL84169.13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
ALL80297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
ALL80337.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
ALL80360.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (270 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (528 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisAPhosphoribosyl isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
hisCHistidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
hisD-3Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (446 aa)
ALL80427.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (468 aa)
ALL80436.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
ALL80445.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (447 aa)
ALL84236.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (309 aa)
dapFHypothetical protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa)
ALL80772.1N-acetylglutamate synthase; Catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. (169 aa)
dapA-3Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (342 aa)
ALL84310.1Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (234 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (379 aa)
ALL80872.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1126 aa)
ALL84364.1Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
ALL84375.1Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
ALL81004.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (387 aa)
ALL81023.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
ALL81062.1Serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa)
ALL81068.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
ALL84401.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
ALL81164.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1126 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ALL81227.1Gamma-glutamyl phosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
ALL81230.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
ALL84436.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
ALL81316.1Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (312 aa)
ALL81333.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
ALL81367.1Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
ALL81369.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
ALL81370.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
ALL81524.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (436 aa)
ALL81526.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (382 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (377 aa)
ALL81640.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
ALL81647.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (359 aa)
ALL81691.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (421 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (598 aa)
ALL81714.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (354 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
ALL81875.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
ALL82049.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (342 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
ALL82114.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
pfkA-2Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (458 aa)
ALL82235.1Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (767 aa)
ALL82305.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ALL82309.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (244 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (474 aa)
ALL82561.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
ALL82572.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (743 aa)
ALL82588.1Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ALL84766.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
ALL82621.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (350 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (411 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (484 aa)
ALL84795.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
ALL84796.1Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (443 aa)
ALL82795.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (569 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (613 aa)
ALL84828.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
ALL84829.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
ilvC-2Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
ALL82821.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (536 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (346 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
ALL82840.1Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ALL82891.1Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
ALL82934.1GltA; Derived by automated computational analysis using gene prediction method: Protein Homology. (1766 aa)
trpFPhosphoribosylanthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (206 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
ALL84879.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1516 aa)
dapA-4Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa)
ALL83101.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa)
ALL83314.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
ALL83320.1Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (648 aa)
ALL83492.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the shikimate dehydrogenase family. (279 aa)
ALL83494.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (400 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (229 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (373 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (405 aa)
ALL85013.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (232 aa)
ALL83606.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (393 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (262 aa)
trpB-2Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (419 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (369 aa)
ALL83619.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transketolase family. (708 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
ALL83846.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial solute-binding protein 3 family. (263 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1203 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (296 aa)
ALL85117.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
ALL84014.13-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa)
ALL84034.1Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (623 aa)
ALL84036.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (301 aa)
Your Current Organism:
Pseudonocardia sp. EC08061901
NCBI taxonomy Id: 1096856
Other names: P. sp. EC080619-01, Pseudonocardia sp. EC080619-01
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