STRINGSTRING
hisIE hisIE hisG hisG hisD hisD AGQ13051.1 AGQ13051.1 hisZ hisZ AGQ15694.1 AGQ15694.1 AGQ15759.1 AGQ15759.1 hisB hisB hisH1 hisH1 hisA hisA hisF hisF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisIEPhosphoribosyl-AMP cyclohydrolase; COG:COG0139; In the N-terminal section; belongs to the PRA-CH family. (257 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (227 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa)
AGQ13051.1Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; COG:COG0079. (361 aa)
hisZATP phosphoribosyltransferase involved in histidine biosynthesis; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (388 aa)
AGQ15694.1Phosphoserine phosphatase; COG:COG0560. (197 aa)
AGQ15759.1Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; COG:COG0483; Belongs to the inositol monophosphatase superfamily. (276 aa)
hisBImidazoleglycerol-phosphate dehydratase; COG:COG0131. (197 aa)
hisH1Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; COG:COG0106. (243 aa)
hisFImidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
Your Current Organism:
Acinetobacter baumannii BJAB07104
NCBI taxonomy Id: 1096995
Other names: A. baumannii BJAB07104, Acinetobacter baumannii str. BJAB07104, Acinetobacter baumannii strain BJAB07104
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.