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| | anmK | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (375 aa) |
| | hpt | Hypoxanthine-guanine phosphoribosyltransferase; COG:COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa) |
| | ribF | FAD synthase; COG:COG0196; Belongs to the ribF family. (333 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; COG:COG0157; Belongs to the NadC/ModD family. (281 aa) |
| | AGQ12458.1 | ATPases involved in chromosome partitioning; COG:COG0489. (728 aa) |
| | wzb | Protein-tyrosine-phosphatase; COG:COG0394; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (142 aa) |
| | AGQ12471.1 | COG:COG0399. (391 aa) |
| | gpi | Glucose-6-phosphate isomerase; COG:COG0166; Belongs to the GPI family. (556 aa) |
| | AGQ12511.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; COG:COG0365. (548 aa) |
| | guaA | GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (522 aa) |
| | atpB | F0F1-type ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (291 aa) |
| | atpE | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpF | F0F1-type ATP synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | F0F1-type ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpA | F0F1-type ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (514 aa) |
| | atpG | F0F1-type ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa) |
| | atpD | F0F1-type ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (464 aa) |
| | atpC | F0F1-type ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | AGQ12586.1 | Hypothetical protein; COG:COG4222. (419 aa) |
| | ppa | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (175 aa) |
| | strB | Streptomycin 6-kinase; COG:COG3570. (276 aa) |
| | strA | Aminoglycoside phosphotransferase; COG:COG3231; Belongs to the aminoglycoside phosphotransferase family. (281 aa) |
| | AGQ12668.1 | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (515 aa) |
| | AGQ12671.1 | Signal transduction histidine kinase; COG:COG0642. (507 aa) |
| | nudF | NTP pyrophosphohydrolase including oxidative damage repair enzyme; COG:COG0494. (208 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (625 aa) |
| | ypdA | Putative signal transduction protein with a C-terminal ATPase domain; COG:COG2972. (379 aa) |
| | AGQ12740.1 | Acyl-CoA thioesterase; COG:COG1946. (264 aa) |
| | AGQ12741.1 | Phosphatidylglycerophosphate synthase; COG:COG0558; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa) |
| | AGQ12749.1 | Putative transcriptional regulator; COG:COG1678; Belongs to the UPF0301 (AlgH) family. (184 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (264 aa) |
| | AGQ12776.1 | Putative unusual protein kinase; COG:COG0661. (539 aa) |
| | AGQ12780.1 | Hypothetical protein; COG:COG2326. (472 aa) |
| | AGQ12800.1 | Putative Mg2+ and Co2+ transporter CorC; COG:COG4535. (279 aa) |
| | AGQ12805.1 | Hypothetical protein; Similar to gene ACICU_00391 in CP000863. (334 aa) |
| | AGQ12815.1 | Putative unusual protein kinase; COG:COG0661. (432 aa) |
| | AGQ12827.1 | Putative phosphatase; COG:COG0546. (224 aa) |
| | AGQ12834.1 | Signal transduction protein containing GAF and PtsI domains; COG:COG3605; Belongs to the PEP-utilizing enzyme family. (764 aa) |
| | AGQ12840.1 | Hypothetical protein; Similar to gene ACICU_00424 in CP000863. (84 aa) |
| | AGQ12857.1 | Lauroyl/myristoyl acyltransferase; COG:COG1560. (311 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (280 aa) |
| | AGQ12895.1 | Xanthosine triphosphate pyrophosphatase; COG:COG0127. (208 aa) |
| | AGQ12908.1 | Phosphotransacetylase; COG:COG0280. (714 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (420 aa) |
| | gntK | Gluconate kinase; COG:COG3265. (165 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | ispG | Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (371 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; COG:COG0152; Belongs to the SAICAR synthetase family. (239 aa) |
| | AGQ16078.1 | Lactoylglutathione lyase-related lyase; COG:COG0346. (182 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (439 aa) |
| | AGQ16057.1 | Phosphatidylglycerophosphatase A-related protein; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (103 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (305 aa) |
| | serB | Phosphoserine phosphatase; COG:COG0560. (378 aa) |
| | pncB | Nicotinic acid phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (354 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (283 aa) |
| | phoR | Signal transduction histidine kinase; COG:COG0642. (452 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (300 aa) |
| | aceE | Pyruvate dehydrogenase complex, dehydrogenase (E1) component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (905 aa) |
| | aceF | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; COG:COG0508. (659 aa) |
| | guaB_2 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | pdxH | Pyridoxamine-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | AGQ15971.1 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (430 aa) |
| | acs | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | rpfC | Na+/proline symporter; COG:COG0591. (1165 aa) |
| | thrB | Putative homoserine kinase type II (protein kinase fold); COG:COG2334; Belongs to the pseudomonas-type ThrB family. (316 aa) |
| | cat1 | Acetyl-CoA hydrolase; COG:COG0427. (504 aa) |
| | envZ | Signal transduction histidine kinase; COG:COG0642. (485 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (189 aa) |
| | AGQ15829.1 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; COG:COG0317. (701 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa) |
| | ispH | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (316 aa) |
| | AGQ15760.1 | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (634 aa) |
| | AGQ15759.1 | Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; COG:COG0483; Belongs to the inositol monophosphatase superfamily. (276 aa) |
| | AGQ15743.1 | Glycerol-3-phosphate O-acyltransferase; COG:COG2937; Belongs to the GPAT/DAPAT family. (856 aa) |
| | tesB | Acyl-CoA thioesterase; COG:COG1946. (290 aa) |
| | AGQ15694.1 | Phosphoserine phosphatase; COG:COG0560. (197 aa) |
| | xpt | Adenine/guanine phosphoribosyltransferase-related PRPP-binding protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa) |
| | pssA | Phosphatidylserine synthase; COG:COG1183; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (277 aa) |
| | pdxA | Pyridoxal phosphate biosynthesis protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (324 aa) |
| | AGQ15647.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; COG:COG0204. (269 aa) |
| | cls_2 | Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase-related enzyme; COG:COG1502. (541 aa) |
| | AGQ15645.1 | Putative phosphohydrolase; COG:COG1408. (336 aa) |
| | AGQ15636.1 | Acyl-CoA hydrolase; COG:COG1607. (140 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (417 aa) |
| | AGQ15614.1 | Signal transduction histidine kinase; COG:COG0642. (422 aa) |
| | AGQ15597.1 | Hypothetical protein; Similar to gene ACICU_03141 in CP000863. (487 aa) |
| | baeS | Signal transduction histidine kinase; COG:COG0642. (518 aa) |
| | accD | Acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa) |
| | AGQ15569.1 | Protein tyrosine/serine phosphatase; COG:COG2365. (192 aa) |
| | AGQ15547.1 | Hypothetical protein; COG:COG2764. (147 aa) |
| | AGQ15511.1 | Chemotaxis protein histidine kinase-related kinase; COG:COG0643. (1506 aa) |
| | AGQ15481.1 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (170 aa) |
| | uppP | Putative bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa) |
| | AGQ15458.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; COG:COG0204. (208 aa) |
| | pmrB | Signal transduction histidine kinase; COG:COG0642. (444 aa) |
| | AGQ15437.1 | Membrane-associated phospholipid phosphatase; COG:COG0671. (208 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (398 aa) |
| | AGQ15405.1 | Dihydrolipoyl dehydrogenase; COG:COG1249. (477 aa) |
| | sucD | Succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | carB | Carbamoylphosphate synthase large subunit; COG:COG0458; Belongs to the CarB family. (1076 aa) |
| | carA | Carbamoylphosphate synthase small subunit; COG:COG0505; Belongs to the CarA family. (379 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | GlpK | Glycerol kinase; COG:COG0554. (502 aa) |
| | AGQ15373.1 | Glycerol-3-phosphate dehydrogenase; COG:COG0578. (505 aa) |
| | AGQ15371.1 | Sphingosine kinase and enzymes; COG:COG1597; related to eukaryotic diacylglycerol kinase. (312 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (124 aa) |
| | AGQ15346.1 | Glycerate kinase; COG:COG1929. (385 aa) |
| | fdhD | Uncharacterized protein required for formate dehydrogenase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (263 aa) |
| | AGQ15327.1 | 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family; COG:COG1807. (548 aa) |
| | AGQ15325.1 | Glycosyltransferases involved in cell wall biogenesis; COG:COG0463. (326 aa) |
| | AGQ15310.1 | Lauroyl/myristoyl acyltransferase; COG:COG1560. (319 aa) |
| | purN | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa) |
| | purM | Phosphoribosylaminoimidazole (AIR) synthetase; COG:COG0150. (356 aa) |
| | AGQ15286.1 | dGTP triphosphohydrolase; COG:COG0232. (446 aa) |
| | AGQ15285.1 | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; COG:COG0046; In the N-terminal section; belongs to the FGAMS family. (1277 aa) |
| | AGQ15279.1 | Nicotinamide mononucleotide adenylyltransferase; COG:COG1056. (196 aa) |
| | AGQ15261.1 | Thymidylate kinase; COG:COG0125. (199 aa) |
| | nadB | Aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (549 aa) |
| | AGQ15232.1 | Glutamate 5-kinase; COG:COG0263. (377 aa) |
| | AGQ15231.1 | Phosphoserine phosphatase; COG:COG0560. (218 aa) |
| | AGQ15200.1 | Thiamine monophosphate synthase; COG:COG0352. (203 aa) |
| | purB | Adenylosuccinate lyase; COG:COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (462 aa) |
| | AGQ15165.1 | Putative acid phosphatase; COG:COG0496. (255 aa) |
| | eutQ | Hypothetical protein; Similar to gene ACICU_02606 in CP000863. (117 aa) |
| | folE | GTP cyclohydrolase I; COG:COG0302. (184 aa) |
| | AGQ15011.1 | Signal transduction histidine kinase; COG:COG0642. (452 aa) |
| | ppnK | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (302 aa) |
| | thiG | Putative enzyme of thiazole biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa) |
| | thiS | Hypothetical protein; Similar to gene ACICU_02466 in CP000863. (65 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; COG:COG0240; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (357 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (334 aa) |
| | AGQ14977.1 | Glutamine phosphoribosylpyrophosphate amidotransferase; COG:COG0034. (513 aa) |
| | AGQ14966.1 | Hypothetical protein; Similar to gene ACICU_02441 in CP000863. (224 aa) |
| | purD | Phosphoribosylamine-glycine ligase; COG:COG0151; Belongs to the GARS family. (428 aa) |
| | purH | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); COG:COG0138. (524 aa) |
| | ppsA | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | ppsR | Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (278 aa) |
| | AGQ14872.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; COG:COG0365. (547 aa) |
| | AGQ14870.1 | Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; COG:COG0476. (258 aa) |
| | AGQ14869.1 | Putative unusual protein kinase; COG:COG0661. (432 aa) |
| | AGQ14867.1 | Hypothetical protein; Similar to gene ACICU_02342 in CP000863. (145 aa) |
| | AGQ14862.1 | Osmosensitive K+ channel histidine kinase; COG:COG2205. (884 aa) |
| | AGQ14857.1 | Permeases of the major facilitator superfamily; COG:COG0477. (440 aa) |
| | lpxH | Hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (239 aa) |
| | AGQ14819.1 | Hydroxyethylthiazole kinase, sugar kinase family; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ). Belongs to the Thz kinase family. (275 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (329 aa) |
| | AGQ14770.1 | 3-carboxymuconate cyclase; COG:COG2706. (414 aa) |
| | yfkJ | Protein-tyrosine-phosphatase; COG:COG0394; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (167 aa) |
| | AGQ14725.1 | Hypothetical protein; Similar to gene ACICU_01404 in CP000863. (267 aa) |
| | cinA1 | Uncharacterized protein (competence- and mitomycin-induced); COG:COG1546; Belongs to the CinA family. (159 aa) |
| | AGQ14694.1 | Signal transduction histidine kinase; COG:COG0642. (1151 aa) |
| | mdcB | Triphosphoribosyl-dephospho-CoA synthetase; Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase; Belongs to the CitG/MdcB family. (294 aa) |
| | AGQ14664.1 | Acetyl-CoA carboxylase beta subunit; COG:COG0777. (283 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (402 aa) |
| | AGQ14588.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; COG:COG0204. (181 aa) |
| | AGQ14565.1 | Putative sugar kinase; COG:COG0063. (486 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | AGQ14548.1 | Hypothetical protein; COG:COG2320. (157 aa) |
| | maf | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | pgk | 3-phosphoglycerate kinase; COG:COG0126; Belongs to the phosphoglycerate kinase family. (395 aa) |
| | fbaA | Fructose/tagatose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa) |
| | AGQ14526.1 | Putative phosphotransferase; COG:COG3178; related to Ser/Thr protein kinase. (337 aa) |
| | AGQ14518.1 | Tetraacyldisaccharide-1-P 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (336 aa) |
| | cmk | Cytidylate kinase; COG:COG0283. (228 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (227 aa) |
| | cysQ | 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (285 aa) |
| | cyaA | Adenylate cyclase, family 3 (some proteins containing HAMP domain); COG:COG2114. (489 aa) |
| | AGQ14451.1 | Putative unusual protein kinase; COG:COG0661. (457 aa) |
| | cobU | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (172 aa) |
| | AGQ14431.1 | Fructose-2,6-bisphosphatase; COG:COG0406. (192 aa) |
| | lpxB | Lipid A disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (391 aa) |
| | AGQ14384.1 | ABC transporter substrate-binding protein; COG:COG1071. (320 aa) |
| | AGQ14382.1 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; COG:COG0508. (496 aa) |
| | AGQ14324.1 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase-related esterase; COG:COG0737; Belongs to the 5'-nucleotidase family. (593 aa) |
| | AGQ14323.1 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). (691 aa) |
| | AGQ14314.1 | Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase-related enzyme; COG:COG1502. (508 aa) |
| | adeS | Signal transduction histidine kinase; COG:COG0642. (357 aa) |
| | AGQ14265.1 | Hypothetical protein; Similar to gene ACICU_01841 in CP000863. (146 aa) |
| | AGQ14263.1 | Hypothetical protein; Similar to gene ACICU_01843 in CP000863. (322 aa) |
| | AGQ14239.1 | Nicotinic acid phosphoribosyltransferase; COG:COG1488; Belongs to the NAPRTase family. (497 aa) |
| | AGQ14238.1 | Phosphoribosylpyrophosphate synthetase; COG:COG0462. (294 aa) |
| | AGQ14161.1 | Fructose-2,6-bisphosphatase; COG:COG0406. (242 aa) |
| | ispD | 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (238 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa) |
| | pyrG | CTP synthase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa) |
| | AGQ14074.1 | Sugar kinase, ribokinase family; COG:COG0524. (334 aa) |
| | AGQ14048.1 | Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria); COG:COG1080; Belongs to the PEP-utilizing enzyme family. (952 aa) |
| | pfkB | Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); COG:COG1105; Belongs to the carbohydrate kinase PfkB family. (315 aa) |
| | AGQ14033.1 | Kynureninase; COG:COG3844. (416 aa) |
| | AGQ14027.1 | Putative hydrolase (HAD superfamily); COG:COG1011. (228 aa) |
| | lpxA | Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | fabZ | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (161 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (356 aa) |
| | AGQ14016.1 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; COG:COG0743. (398 aa) |
| | cdsA | CDP-diglyceride synthetase; COG:COG0575; Belongs to the CDS family. (274 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | glnL | Signal transduction histidine kinase, nitrogen specific; COG:COG3852. (369 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | AGQ13989.1 | Molybdopterin biosynthesis enzyme; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (411 aa) |
| | AGQ13988.1 | Molybdenum cofactor biosynthesis enzyme; COG:COG0315. (307 aa) |
| | moaE | Molybdopterin converting factor, large subunit; COG:COG0314. (161 aa) |
| | AGQ13986.1 | Hypothetical protein; Similar to gene ACICU_02124 in CP000863. (84 aa) |
| | AGQ13985.1 | Molybdenum cofactor biosynthesis enzyme; COG:COG2896. (344 aa) |
| | AGQ13983.1 | Molybdopterin-guanine dinucleotide biosynthesis protein A; COG:COG0746. (189 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | AGQ13909.1 | Hypothetical protein. (296 aa) |
| | htrB_3 | Lauroyl/myristoyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (310 aa) |
| | AGQ13709.1 | Dihydroorotase-related cyclic amidohydrolase; COG:COG0044. (411 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic chain; COG:COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (338 aa) |
| | pncC | Uncharacterized protein (competence- and mitomycin-induced); COG:COG1546; Belongs to the CinA family. (162 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (439 aa) |
| | AGQ13693.1 | Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; COG:COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa) |
| | lysC | Aspartokinase; COG:COG0527; Belongs to the aspartokinase family. (426 aa) |
| | AGQ13686.1 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (332 aa) |
| | pyrC_3 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | nudC | NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; COG:COG2816. (247 aa) |
| | adk | Adenylate kinase-related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | ppk1 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (692 aa) |
| | AGQ13440.1 | Hypothetical protein; Similar to gene ACICU_00936 in CP000863. (515 aa) |
| | AGQ13419.1 | Putative dinucleotide-utilizing enzyme; COG:COG1712. (263 aa) |
| | AGQ13396.1 | Acyl-CoA hydrolase; COG:COG1607. (171 aa) |
| | AGQ13284.1 | Hypothetical protein. (330 aa) |
| | AGQ13272.1 | Putative enzyme; COG:COG3324; related to lactoylglutathione lyase. (125 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa) |
| | dut | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (541 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (135 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (277 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | AGQ13199.1 | Putative phosphatase; COG:COG0546. (224 aa) |
| | AGQ13198.1 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; COG:COG0351. (255 aa) |
| | AGQ13171.1 | Putative transcriptional regulator,-like protein of Bvg accessory factor; COG:COG1521. (244 aa) |
| | dcd | Deoxycytidine deaminase; Catalyzes the deamination of dCTP to dUTP. (189 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa) |
| | bfmS | Signal transduction histidine kinase; COG:COG0642. (530 aa) |
| | nrdA | Ribonucleotide reductase, alpha subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (944 aa) |
| | AGQ13121.1 | Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (427 aa) |
| | AGQ13119.1 | Hypothetical protein; Similar to gene ACICU_00700 in CP000863. (779 aa) |
| | AGQ13078.1 | Adenosine deaminase; COG:COG1816. (339 aa) |
| | AGQ13077.1 | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (354 aa) |
| | rpe | Pentose-5-phosphate-3-epimerase; COG:COG0036; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | AGQ13061.1 | NTP pyrophosphohydrolase including oxidative damage repair enzyme; COG:COG0494. (205 aa) |
| | accA | Acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (273 aa) |
| | AGQ12933.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; COG:COG0204. (264 aa) |
| | gacS | Signal transduction histidine kinase; COG:COG0642. (935 aa) |
| | AGQ12999.1 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; COG:COG0317. (768 aa) |
| | mazG | Putative pyrophosphatase; COG:COG1694. (268 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; COG:COG0801. (160 aa) |
