STRINGSTRING
MCE_01020 MCE_01020 atpF atpF MCE_00800 MCE_00800 atpE atpE atpB atpB lpxD lpxD fabZ fabZ lpxA lpxA MCE_00330 MCE_00330 MCE_00325 MCE_00325 MCE_00685 MCE_00685 MCE_07950 MCE_07950 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC gmk gmk MCE_07385 MCE_07385 MCE_07245 MCE_07245 MCE_07235 MCE_07235 coaE coaE MCE_07145 MCE_07145 MCE_07085 MCE_07085 lpxK lpxK MCE_07015 MCE_07015 tmk tmk adk adk MCE_06355 MCE_06355 MCE_06350 MCE_06350 MCE_05925 MCE_05925 MCE_05905 MCE_05905 MCE_05840 MCE_05840 MCE_05835 MCE_05835 MCE_05830 MCE_05830 cmk cmk MCE_05595 MCE_05595 MCE_05590 MCE_05590 MCE_05550 MCE_05550 MCE_05385 MCE_05385 MCE_04705 MCE_04705 MCE_04700 MCE_04700 MCE_04620 MCE_04620 MCE_04605 MCE_04605 MCE_04560 MCE_04560 MCE_04445 MCE_04445 nrdF nrdF folD folD gpsA gpsA ppnK ppnK MCE_03835 MCE_03835 dut dut folE folE lpxB lpxB MCE_02940 MCE_02940 thyX thyX cysQ cysQ MCE_02670 MCE_02670 MCE_02665 MCE_02665 MCE_02440 MCE_02440 pdhA pdhA lpxC lpxC MCE_02315 MCE_02315 psd psd MCE_02300 MCE_02300 rppH rppH purC purC sucA sucA MCE_01835 MCE_01835 dcd dcd MCE_01125 MCE_01125 ndk ndk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MCE_01020CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (181 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa)
MCE_00800COG0711 F0F1-type ATP synthase, subunit b. (157 aa)
atpEF0F1 ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (241 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
fabZ(3R)-hydroxymyristoyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (264 aa)
MCE_00330PAP2 family phosphoesterase; COG0671 Membrane-associated phospholipid phosphatase. (215 aa)
MCE_00325PhnP protein; COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I. (254 aa)
MCE_00685Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (189 aa)
MCE_07950Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (215 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (510 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (323 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (473 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (112 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (229 aa)
MCE_07385Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (199 aa)
MCE_07245COG1112 Superfamily I DNA and RNA helicases and helicase subunits. (371 aa)
MCE_07235COG1112 Superfamily I DNA and RNA helicases and helicase subunits. (296 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (191 aa)
MCE_07145COG3494 Uncharacterized protein conserved in bacteria. (270 aa)
MCE_07085Guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein SpoT4; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (172 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (322 aa)
MCE_07015COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (201 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
MCE_06355COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (135 aa)
MCE_06350COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (151 aa)
MCE_05925Hypothetical protein; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (249 aa)
MCE_05905COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (66 aa)
MCE_05840COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (235 aa)
MCE_05835COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (851 aa)
MCE_05830COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (246 aa)
cmkCOG0283 Cytidylate kinase. (219 aa)
MCE_05595Hypothetical protein; COG0456 Acetyltransferases. (95 aa)
MCE_05590MazG-like protein; COG1694 Predicted pyrophosphatase. (134 aa)
MCE_05550UDP-N-acetylglucosamine pyrophosphorylase; COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains). (248 aa)
MCE_05385COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (241 aa)
MCE_04705COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (103 aa)
MCE_04700Guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein. (65 aa)
MCE_04620COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (163 aa)
MCE_04605COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (224 aa)
MCE_04560Phospholipase D superfamily protein PLD; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (223 aa)
MCE_04445Branched-chain alpha-keto acid dehydrogenase subunit E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (412 aa)
nrdFRibonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (327 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (326 aa)
ppnKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa)
MCE_03835Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (230 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa)
folECOG0302 GTP cyclohydrolase I. (189 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (446 aa)
MCE_02940(p)ppGpp 3-pyrophosphohydrolase; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (235 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (294 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (258 aa)
MCE_02670COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (66 aa)
MCE_02665COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (129 aa)
MCE_02440Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
pdhAPyruvate dehydrogenase e1 component, alpha subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (326 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (288 aa)
MCE_02315CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (255 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (231 aa)
MCE_02300Extragenic suppressor protein suhB; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (248 aa)
rppHRNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (161 aa)
purCCOG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (236 aa)
sucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (928 aa)
MCE_01835Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
MCE_01125Deoxyguanosinetriphosphate triphosphohydrolase-like protein; COG0232 dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (384 aa)
ndkMulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
Your Current Organism:
Rickettsia amblyommatis
NCBI taxonomy Id: 1105111
Other names: Candidatus Rickettsia amblyommii str. GAT-30V, R. amblyommatis str. GAT-30V, Rickettsia amblyommatis str. GAT-30V
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