(54 nodes) Spliceosomal snRNP complex, and U2-type precatalytic spliceosome network (Serendipita indica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIIN_00432	Related to small nuclear ribonucleoprotein snRNP U1A. (274 aa)
	PIIN_00725	Related to U2 snRNP protein A. (248 aa)
	PIIN_00949	Uncharacterized protein. (750 aa)
	PIIN_01075	Sm domain-containing protein. (65 aa)
	PIIN_01227	Probable Splicing factor 3B subunit 5. (361 aa)
	PIIN_01388	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (142 aa)
	PIIN_01618	Probable splicing factor PRP8 (U5 snRNP). (2347 aa)
	PIIN_01875	Uncharacterized protein. (445 aa)
	PIIN_01909	Probable Splicing factor 3b, subunit 2. (578 aa)
	PIIN_01991	Uncharacterized protein. (687 aa)
	PIIN_01996	Probable U5 snRNP-specific 40 kD protein (Novel WD-40 repeat protein). (357 aa)
	PIIN_02185	U1-type domain-containing protein. (223 aa)
	PIIN_02198	Probable splicing factor 3B subunit 3. (1243 aa)
	PIIN_02395	Related to PRP11-pre-mRNA splicing factor. (223 aa)
	PIIN_02523	Small nuclear ribonucleoprotein Sm D3. (129 aa)
	PIIN_02503	Matrin-type domain-containing protein. (323 aa)
	PIIN_02804	Uncharacterized protein. (507 aa)
	PIIN_02857	Related to SAD1-SnRNP assembly defective. (569 aa)
	PIIN_03064	Related to microfibril-associated protein. (481 aa)
	PIIN_03121	SNRNP27 domain-containing protein. (207 aa)
	MEF1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (751 aa)
	PIIN_03378	Related to U4/U6 snRNP-associated 61 kDa protein. (530 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
	PIIN_03689	Small nuclear ribonucleoprotein Sm D2. (122 aa)
	PIIN_03789	Related to Splicing factor 3 subunit 1. (744 aa)
	PIIN_03775	Related to U4/U6 small nuclear ribonucleoprotein hPrp3. (590 aa)
	PIIN_03890	Probable pre-mRNA splicing factor prp1. (924 aa)
	PIIN_04296	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (123 aa)
	PIIN_04473	Related to ubiquitin-like protein Hub1. (75 aa)
	PIIN_04544	Related to RNA helicase. (1042 aa)
	PIIN_04674	Related to PRP4-U4/U6 small nuclear ribonucleoprotein. (495 aa)
	PIIN_04861	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (172 aa)
	PIIN_05257	Related to small nuclear ribonucleoprotein U2B` (U2 small nuclear RNA-associated protein B`). (146 aa)
	PIIN_05306	Probable splicing factor 3b subunit 1. (1149 aa)
	PIIN_05636	Probable RNA helicase. (1595 aa)
	PIIN_05711	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (94 aa)
	PIIN_06399	Probable ATP dependent RNA helicase. (2180 aa)
	PIIN_06736	Probable U5 snRNP 100 kD protein; Belongs to the DEAD box helicase family. (724 aa)
	PIIN_06800	Related to SNP1-U1 small nuclear ribonucleoprotein. (362 aa)
	PIIN_07270	Uncharacterized protein. (254 aa)
	PIIN_07885	Uncharacterized protein. (88 aa)
	PIIN_08095	Probable ribosomal elongation factor EF-2. (980 aa)
	PIIN_08150	Related to HFM1-DNA/RNA helicase. (1069 aa)
	PIIN_08404	Probable pre-mRNA splicing factor. (139 aa)
	PIIN_08478	Related to small nuclear ribonucleoprotein associated protein b. (163 aa)
	PIIN_08658	Uncharacterized protein. (745 aa)
	PIIN_08782	Uncharacterized protein. (425 aa)
	PIIN_09705	RRM domain-containing protein. (91 aa)
	PIIN_09708	Related to RNA splicing factor PRP9. (518 aa)
	PIIN_10360	Related to HFM1-DNA/RNA helicase. (262 aa)
	PIIN_10439	Related to G-protein beta WD-40 repeats containing protein, putative-Talaromyces stipitatus. (1104 aa)
	PIIN_03422	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (87 aa)
	PIIN_03446	Related to spliceosome-associated protein SAP-49. (298 aa)
	PIIN_01763	Uncharacterized protein. (677 aa)

Your Current Organism:

Serendipita indica

NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM8	MEF1	G4TE29	G4TDP7	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.	0.697
LSM8	PIIN_00432	G4TE29	G4T627	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Related to small nuclear ribonucleoprotein snRNP U1A.	0.862
LSM8	PIIN_00725	G4TE29	G4T6H0	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Related to U2 snRNP protein A.	0.956
LSM8	PIIN_00949	G4TE29	G4T725	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.993
LSM8	PIIN_01075	G4TE29	G4T7H1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Sm domain-containing protein.	0.990
LSM8	PIIN_01227	G4TE29	G4T7U7	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable Splicing factor 3B subunit 5.	0.954
LSM8	PIIN_01388	G4TE29	G4T8B6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.	0.982
LSM8	PIIN_01618	G4TE29	G4T901	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable splicing factor PRP8 (U5 snRNP).	0.991
LSM8	PIIN_01763	G4TE29	G4U3D3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.992
LSM8	PIIN_01875	G4TE29	G4T9L5	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.763
LSM8	PIIN_01909	G4TE29	G4T9Q8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable Splicing factor 3b, subunit 2.	0.915
LSM8	PIIN_01991	G4TE29	G4T9X1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.775
LSM8	PIIN_01996	G4TE29	G4T9Z6	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable U5 snRNP-specific 40 kD protein (Novel WD-40 repeat protein).	0.775
LSM8	PIIN_02185	G4TE29	G4TAG8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	U1-type domain-containing protein.	0.956
LSM8	PIIN_02198	G4TE29	G4TAJ8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Probable splicing factor 3B subunit 3.	0.920
LSM8	PIIN_02395	G4TE29	G4TB38	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Related to PRP11-pre-mRNA splicing factor.	0.926
LSM8	PIIN_02503	G4TE29	G4TBG3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Matrin-type domain-containing protein.	0.753
LSM8	PIIN_02523	G4TE29	G4TBE9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Small nuclear ribonucleoprotein Sm D3.	0.990
LSM8	PIIN_02804	G4TE29	G4TCA9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.590
LSM8	PIIN_02857	G4TE29	G4TCE3	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Related to SAD1-SnRNP assembly defective.	0.890