STRINGSTRING
surE surE purU1 purU1 AFA71727.1 AFA71727.1 purU2 purU2 purN purN purH purH prs prs guaB guaB guaA guaA AFA72707.1 AFA72707.1 add2 add2 upp upp purK purK purE purE pyrH pyrH ribF ribF thyA thyA thyX thyX dut dut AFA73236.1 AFA73236.1 apt apt pyrB pyrB pyrC pyrC AFA73277.1 AFA73277.1 carA carA carB carB pyrF pyrF gmk gmk AFA73318.1 AFA73318.1 pyrD pyrD cmk cmk purA1 purA1 AFA74460.1 AFA74460.1 tmk tmk adk adk purM purM purF purF purL purL purQ purQ purS purS purC purC purB purB purD purD hpt hpt purT purT purA2 purA2 pyrE pyrE AFA75398.1 AFA75398.1 dcd dcd AFA75701.1 AFA75701.1 AFA75935.1 AFA75935.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
surEMultifunctional protein SurE. (259 aa)
purU1Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa)
AFA71727.1Hypothetical protein. (387 aa)
purU2Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (318 aa)
purNPhosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (211 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH. (534 aa)
prsRibose-phosphate pyrophosphokinase Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
guaBInosine-5'-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (503 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (528 aa)
AFA72707.1Putative glutamine amidotransferase. (239 aa)
add2Adenosine deaminase Add; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (376 aa)
uppUracil phosphoribosyltransferase Upp; Belongs to the UPRTase family. (207 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (397 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (189 aa)
pyrHUridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (322 aa)
thyAThymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (162 aa)
AFA73236.1Hypothetical protein. (206 aa)
aptAdenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (195 aa)
pyrBAspartate carbamoyltransferase PyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa)
pyrCDihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa)
AFA73277.1Hypothetical protein. (206 aa)
carACarbamoyl-phosphate synthase small chain CarA; Belongs to the CarA family. (389 aa)
carBCarbamoyl-phosphate synthase large chain CarB; Belongs to the CarB family. (1116 aa)
pyrFOrotidine 5'-phosphate decarboxylase PyrF; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa)
gmkGuanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (196 aa)
AFA73318.1Phosphoribosyltransferase. (173 aa)
pyrDDihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (367 aa)
cmkCytidylate kinase Cmk. (227 aa)
purA1Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (466 aa)
AFA74460.1Putative NUDIX hydrolase. (160 aa)
tmkThymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa)
adkAdenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (184 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase PurM. (373 aa)
purFAmidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (527 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (763 aa)
purQPhosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (227 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is th [...] (79 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (295 aa)
purBAdenylosuccinate lyase PurB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (475 aa)
purDPhosphoribosylamine--glycine ligase PurD; Belongs to the GARS family. (417 aa)
hptHypoxanthine-guanine phosphoribosyltransferase Hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (189 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (546 aa)
purA2Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
pyrEOrotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa)
AFA75398.1Putative secreted protein. (345 aa)
dcdDeoxycytidine triphosphate deaminase Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
AFA75701.1Hypothetical protein. (185 aa)
AFA75935.1Hypothetical protein. (398 aa)
Your Current Organism:
Gordonia polyisoprenivorans
NCBI taxonomy Id: 1112204
Other names: G. polyisoprenivorans VH2, Gordonia polyisoprenivorans VH2, Gordonia polyisoprenivorans str. VH2, Gordonia polyisoprenivorans strain VH2
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