STRINGSTRING
pyk pyk AFA75701.1 AFA75701.1 dcd dcd fba fba pgi pgi AFA74847.1 AFA74847.1 ldh ldh tmk tmk AFA74484.1 AFA74484.1 AFA74460.1 AFA74460.1 pfp pfp dgt dgt aceE aceE dltA dltA pyrG pyrG AFA73347.1 AFA73347.1 tpiA tpiA pgk pgk gapA gapA AFA73236.1 AFA73236.1 dut dut AFA73155.1 AFA73155.1 thyX thyX AFA73115.1 AFA73115.1 thyA thyA pyrH pyrH ndk ndk AFA72912.1 AFA72912.1 atpC atpC atpD atpD atpG atpG atpA atpA atpFH atpFH atpF atpF atpE atpE atpB atpB eno eno AFA72458.1 AFA72458.1 gpmA gpmA AFA71986.1 AFA71986.1 AFA71449.1 AFA71449.1 AFA71373.1 AFA71373.1 AFA71149.1 AFA71149.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pykPyruvate kinase Pyk; Belongs to the pyruvate kinase family. (480 aa)
AFA75701.1Hypothetical protein. (185 aa)
dcdDeoxycytidine triphosphate deaminase Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
fbaFructose-bisphosphate aldolase Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
pgiGlucose-6-phosphate isomerase Pgi; Belongs to the GPI family. (557 aa)
AFA74847.1Hexose kinase, 1-phosphofructokinase family; Belongs to the carbohydrate kinase PfkB family. (319 aa)
ldhL-lactate dehydrogenase Ldh; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (326 aa)
tmkThymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa)
AFA74484.1Hypothetical protein. (308 aa)
AFA74460.1Putative NUDIX hydrolase. (160 aa)
pfpPyrophosphate--fructose 6-phosphate 1-phosphotransferase Pfp; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (344 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase-like protein Dgt; Belongs to the dGTPase family. Type 2 subfamily. (429 aa)
aceEPyruvate dehydrogenase E1 component AceE; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (963 aa)
dltADihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex. (597 aa)
pyrGCTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (561 aa)
AFA73347.1Putative aldolase. (285 aa)
tpiATriosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
pgkPhosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (403 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase GapA; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
AFA73236.1Hypothetical protein. (206 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (162 aa)
AFA73155.1Hexose kinase, 1-phosphofructokinase family; Belongs to the carbohydrate kinase PfkB family. (321 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
AFA73115.1Hypothetical protein. (338 aa)
thyAThymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
pyrHUridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
ndkNucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa)
AFA72912.1Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (213 aa)
atpCATP synthase epsilon chain AtpC; Produces ATP from ADP in the presence of a proton gradient across the membrane. (126 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (482 aa)
atpGATP synthase gamma chain AtpG; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (315 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (542 aa)
atpFHATP synthase subunit b-delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family. (449 aa)
atpFATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (170 aa)
atpEATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (87 aa)
atpBATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (252 aa)
enoEnolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
AFA72458.1Putative nucleoside triphosphate pyrophosphohydrolase. (385 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
AFA71986.1Dihydrolipoyl dehydrogenase. (461 aa)
AFA71449.1Putative phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (233 aa)
AFA71373.1Putative pyruvate dehydrogenase E1 component. (778 aa)
AFA71149.1Putative phosphoglycerate mutase family protein. (202 aa)
Your Current Organism:
Gordonia polyisoprenivorans
NCBI taxonomy Id: 1112204
Other names: G. polyisoprenivorans VH2, Gordonia polyisoprenivorans VH2, Gordonia polyisoprenivorans str. VH2, Gordonia polyisoprenivorans strain VH2
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