STRINGSTRING
cobIJ cobIJ AFA71166.1 AFA71166.1 AFA71513.1 AFA71513.1 thiE thiE thiO thiO thiS thiS thiG thiG AFA71769.1 AFA71769.1 AFA71835.1 AFA71835.1 thiD thiD thiC thiC AFA72369.1 AFA72369.1 AFA72701.1 AFA72701.1 cobA1 cobA1 cbiM cbiM AFA72867.1 AFA72867.1 cobQ cobQ cobA2 cobA2 ribF ribF AFA73162.1 AFA73162.1 dxs dxs AFA73204.1 AFA73204.1 pdxS pdxS pdxT pdxT ribD ribD ribE ribE ribBA ribBA ribH ribH AFA73300.1 AFA73300.1 AFA73321.1 AFA73321.1 cobL cobL cobM cobM cobK cobK cobH cobH cobN cobN pdxK pdxK AFA73594.1 AFA73594.1 AFA73618.1 AFA73618.1 bioB bioB bioD bioD bioF bioF bioA bioA cobT cobT cobS cobS panB panB cobD cobD thiL thiL AFA74231.1 AFA74231.1 AFA74435.1 AFA74435.1 AFA74656.1 AFA74656.1 cobF cobF AFA74920.1 AFA74920.1 pdxH pdxH serC serC AFA75079.1 AFA75079.1 panD panD panC panC folK folK folB folB folP2 folP2 AFA75541.1 AFA75541.1 AFA75698.1 AFA75698.1 panE panE
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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cobIJCobalamin biosynthesis protein CobIJ. (507 aa)
AFA71166.1Putative 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (318 aa)
AFA71513.1Putative aldo/keto reductase. (276 aa)
thiEThiamine-phosphate pyrophosphorylase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (177 aa)
thiOPutative glycine oxidase ThiO. (370 aa)
thiSThiamine biosynthesis protein ThiS. (65 aa)
thiGThiazole synthase ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)
AFA71769.1CobW family protein. (411 aa)
AFA71835.1NMT1/THI5-like protein. (367 aa)
thiDPhosphomethylpyrimidine kinase ThiD. (290 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (563 aa)
AFA72369.1Cobalamin synthesis CobW-like protein. (446 aa)
AFA72701.1Aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
cobA1cob(I)yrinic acid a,c-diamide adenosyltransferase CobA; Belongs to the Cob(I)alamin adenosyltransferase family. (204 aa)
cbiMPutative cobalamin (vitamin B12) biosynthesis protein CbiM. (241 aa)
AFA72867.1Putative membrane protein. (139 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (528 aa)
cobA2cob(I)yrinic acid a,c-diamide adenosyltransferase CobA. (205 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (322 aa)
AFA73162.1Putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (412 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase Dxs; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (663 aa)
AFA73204.1Putative riboflavin-specific deaminase. (254 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (282 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (343 aa)
ribERiboflavin synthase alpha chain RibE. (220 aa)
ribBARiboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (449 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase RibH; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (171 aa)
AFA73300.1Protein of unknown function DUF2581. (152 aa)
AFA73321.1Hypothetical protein. (129 aa)
cobLprecorrin-6Y C(5,15)-methyltransferase. (427 aa)
cobMPrecorrin-4 C(11)-methyltransferase CobM. (265 aa)
cobKprecorrin-6A reductase CobK. (244 aa)
cobHprecorrin-8X methylmutase CobH. (221 aa)
cobNAerobic cobaltochelatase subunit CobN. (1218 aa)
pdxKPyridoxine kinase PdxK. (263 aa)
AFA73594.1Glyoxalase/bleomycin resistance protein/dioxygenase. (127 aa)
AFA73618.1Thiamin pyrophosphokinase, catalytic subunit. (395 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa)
bioDDethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (248 aa)
bioF8-amino-7-oxononanoate synthase. (396 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (432 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (615 aa)
cobSCobalamin synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (267 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (298 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (295 aa)
thiLThiamine-monophosphate kinase ThiL; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (377 aa)
AFA74231.1Cobalamin synthesis protein/P47K. (382 aa)
AFA74435.1Putative 2,5-didehydrogluconate reductase. (276 aa)
AFA74656.1Putative creatinine amidohydrolase. (237 aa)
cobFprecorrin-6A synthase (deacetylating). (252 aa)
AFA74920.1Putative FAD-dependent oxidoreductase. (436 aa)
pdxHPyridoxine/pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (249 aa)
serCPhosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (380 aa)
AFA75079.1Putative aminotransferase. (296 aa)
panDAspartate 1-decarboxylase PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (144 aa)
panCPantothenate synthetase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (306 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK. (185 aa)
folBDihydroneopterin aldolase FolB; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa)
folP2Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (295 aa)
AFA75541.1Putative oxidoreductase, aldo/keto reductase family. (272 aa)
AFA75698.1CobB/CobQ domain-containing protein. (239 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (301 aa)
Your Current Organism:
Gordonia polyisoprenivorans
NCBI taxonomy Id: 1112204
Other names: G. polyisoprenivorans VH2, Gordonia polyisoprenivorans VH2, Gordonia polyisoprenivorans str. VH2, Gordonia polyisoprenivorans strain VH2
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