STRINGSTRING
surE surE AFA71623.1 AFA71623.1 AFA71946.1 AFA71946.1 hyuA hyuA cdd cdd deoA deoA upp upp punA punA ndk ndk pyrH pyrH thyA thyA thyX thyX dut dut pyrR pyrR pyrB pyrB pyrC pyrC carA carA carB carB pyrF pyrF pyrD pyrD cmk cmk pyrG pyrG nrdF2 nrdF2 nrdE nrdE tmk tmk pyrE pyrE dcd dcd AFA75666.1 AFA75666.1 AFA75680.1 AFA75680.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
surEMultifunctional protein SurE. (259 aa)
AFA71623.1Ribonucleotide reductase small subunit-like protein. (323 aa)
AFA71946.1Carbon-nitrogen hydrolase family protein. (282 aa)
hyuAD-hydantoinase HyuA. (473 aa)
cddCytidine deaminase Cdd. (139 aa)
deoAThymidine phosphorylase DeoA. (448 aa)
uppUracil phosphoribosyltransferase Upp; Belongs to the UPRTase family. (207 aa)
punAPurine nucleoside phosphorylase PunA; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (267 aa)
ndkNucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa)
pyrHUridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
thyAThymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (162 aa)
pyrRBifunctional protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (195 aa)
pyrBAspartate carbamoyltransferase PyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa)
pyrCDihydroorotase PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa)
carACarbamoyl-phosphate synthase small chain CarA; Belongs to the CarA family. (389 aa)
carBCarbamoyl-phosphate synthase large chain CarB; Belongs to the CarB family. (1116 aa)
pyrFOrotidine 5'-phosphate decarboxylase PyrF; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa)
pyrDDihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (367 aa)
cmkCytidylate kinase Cmk. (227 aa)
pyrGCTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (561 aa)
nrdF2Ribonucleoside-diphosphate reductase subunit beta NrdF2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (336 aa)
nrdERibonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (735 aa)
tmkThymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa)
pyrEOrotate phosphoribosyltransferase PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa)
dcdDeoxycytidine triphosphate deaminase Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
AFA75666.1Putative cytosine deaminase. (167 aa)
AFA75680.1Carbon-nitrogen hydrolase family protein. (296 aa)
Your Current Organism:
Gordonia polyisoprenivorans
NCBI taxonomy Id: 1112204
Other names: G. polyisoprenivorans VH2, Gordonia polyisoprenivorans VH2, Gordonia polyisoprenivorans str. VH2, Gordonia polyisoprenivorans strain VH2
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