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AFC27957.1 AFC27957.1 AFC27958.1 AFC27958.1 AFC28837.1 AFC28837.1 AFC29121.1 AFC29121.1 AFC29598.1 AFC29598.1 AFC29601.1 AFC29601.1 AFC29630.1 AFC29630.1 AFC31739.1 AFC31739.1 AFC27495.1 AFC27495.1 leuD leuD AFC32089.1 AFC32089.1 ilvD ilvD AFC27606.1 AFC27606.1 AFC27607.1 AFC27607.1 ilvC ilvC leuA leuA leuB leuB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFC27957.1IlvB2. (588 aa)
AFC27958.1Acetolactate synthase, small subunit. (169 aa)
AFC28837.1AIPM/Hcit synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
AFC29121.1Tartrate dehydrogenase. (364 aa)
AFC29598.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (549 aa)
AFC29601.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (559 aa)
AFC29630.1IlvK. (361 aa)
AFC31739.1Glu/Leu/Phe/Val dehydrogenase dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (347 aa)
AFC27495.1Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. (518 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
AFC32089.1LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa)
ilvDIlvD; Belongs to the IlvD/Edd family. (561 aa)
AFC27606.1IlvB. (580 aa)
AFC27607.1IlvH. (160 aa)
ilvCIlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
leuALeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
leuBLeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
Your Current Organism:
Paenibacillus mucilaginosus
NCBI taxonomy Id: 1116391
Other names: P. mucilaginosus 3016, Paenibacillus mucilaginosus 3016, Paenibacillus mucilaginosus str. 3016, Paenibacillus mucilaginosus strain 3016
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