STRINGSTRING
addB addB AFC27981.1 AFC27981.1 AFC28371.1 AFC28371.1 AFC28545.1 AFC28545.1 AFC27147.1 AFC27147.1 AFC28719.1 AFC28719.1 PM3016_21 PM3016_21 AFC29814.1 AFC29814.1 AFC29954.1 AFC29954.1 AFC29955.1 AFC29955.1 AFC30033.1 AFC30033.1 AFC30080.1 AFC30080.1 AFC30131.1 AFC30131.1 AFC31263.1 AFC31263.1 AFC31348.1 AFC31348.1 AFC31750.1 AFC31750.1 topA topA AFC31895.1 AFC31895.1 recG recG priA priA AFC32167.1 AFC32167.1 dnaG dnaG addA addA ruvB ruvB ruvA ruvA AFC32766.1 AFC32766.1 AFC33022.1 AFC33022.1 AFC33299.1 AFC33299.1 gyrB gyrB AFC33725.1 AFC33725.1 AFC33845.1 AFC33845.1 AFC33890.1 AFC33890.1 AFC34028.1 AFC34028.1 gyrA gyrA PM3016_86 PM3016_86 PM3016_92 PM3016_92
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
addBATP-dependent nuclease subunit B; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1195 aa)
AFC27981.1Small, acid-soluble spore protein C. (75 aa)
AFC28371.1Replicative DNA helicase. (425 aa)
AFC28545.1Small, acid-soluble spore protein D. (74 aa)
AFC27147.1PcrA. (771 aa)
AFC28719.1Small acid-soluble spore protein alpha/beta type. (95 aa)
PM3016_21ATP-dependent DNA helicase replicase. (776 aa)
AFC29814.1YqxK. (393 aa)
AFC29954.1ParE. (657 aa)
AFC29955.1ParC. (811 aa)
AFC30033.1YprA. (761 aa)
AFC30080.1DNA topoisomerase III. (723 aa)
AFC30131.1Putative DNA topoisomerase III. (680 aa)
AFC31263.1Small, acid-soluble spore protein, alpha/beta. (73 aa)
AFC31348.1UvrD/REP helicase. (766 aa)
AFC31750.1UvrD/REP helicase. (791 aa)
topATopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] (701 aa)
AFC31895.1Sigma 54 interacting domain-containing protein. (539 aa)
recGRecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (683 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (833 aa)
AFC32167.1Replicative DNA helicase. (425 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (611 aa)
addAATP-dependent deoxyribonuclease; ATP-dependent DNA helicase. (1384 aa)
ruvBRuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (215 aa)
AFC32766.1Hypothetical protein. (70 aa)
AFC33022.1HRDC domain-containing protein. (336 aa)
AFC33299.1NERD domain-containing protein. (641 aa)
gyrBGyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (637 aa)
AFC33725.1SspF. (152 aa)
AFC33845.1ArsR family transcriptional regulator. (374 aa)
AFC33890.1Rtel-1. (773 aa)
AFC34028.1DnaC; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (455 aa)
gyrAGyrA; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (835 aa)
PM3016_86Small acid-soluble spore protein. (89 aa)
PM3016_92Helicase domain-containing protein. (594 aa)
Your Current Organism:
Paenibacillus mucilaginosus
NCBI taxonomy Id: 1116391
Other names: P. mucilaginosus 3016, Paenibacillus mucilaginosus 3016, Paenibacillus mucilaginosus str. 3016, Paenibacillus mucilaginosus strain 3016
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