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fadB fadB fadA fadA M5M_01880 M5M_01880 M5M_01885 M5M_01885 M5M_01890 M5M_01890 M5M_01895 M5M_01895 M5M_01900 M5M_01900 M5M_01905 M5M_01905 M5M_01910 M5M_01910 M5M_01915 M5M_01915 M5M_01920 M5M_01920 M5M_01990 M5M_01990 M5M_01995 M5M_01995 M5M_02030 M5M_02030 M5M_02035 M5M_02035 M5M_02040 M5M_02040 M5M_03570 M5M_03570 M5M_03955 M5M_03955 M5M_03960 M5M_03960 M5M_03975 M5M_03975 M5M_04880 M5M_04880 M5M_04885 M5M_04885 M5M_06335 M5M_06335 M5M_06340 M5M_06340 M5M_06345 M5M_06345 M5M_06350 M5M_06350 M5M_06355 M5M_06355 M5M_06395 M5M_06395 M5M_08340 M5M_08340 M5M_08490 M5M_08490 M5M_08495 M5M_08495 M5M_08500 M5M_08500 M5M_08505 M5M_08505 M5M_08510 M5M_08510 M5M_08515 M5M_08515 M5M_08520 M5M_08520 M5M_08525 M5M_08525 M5M_08535 M5M_08535 M5M_08540 M5M_08540 M5M_08545 M5M_08545 M5M_08550 M5M_08550 M5M_08555 M5M_08555 M5M_08560 M5M_08560 M5M_09945 M5M_09945 M5M_10055 M5M_10055 M5M_10060 M5M_10060 M5M_10065 M5M_10065 M5M_10070 M5M_10070 M5M_10075 M5M_10075 M5M_10080 M5M_10080 acsA acsA M5M_10610 M5M_10610 M5M_10615 M5M_10615 M5M_10620 M5M_10620 M5M_10630 M5M_10630 M5M_10635 M5M_10635 M5M_13850 M5M_13850 M5M_14105 M5M_14105 M5M_15125 M5M_15125 M5M_15130 M5M_15130 M5M_15135 M5M_15135 M5M_15140 M5M_15140 M5M_15145 M5M_15145 M5M_15147 M5M_15147 M5M_15160 M5M_15160 M5M_16255 M5M_16255 M5M_16260 M5M_16260 M5M_16265 M5M_16265 M5M_16270 M5M_16270 M5M_16840 M5M_16840 M5M_17725 M5M_17725 fadB-2 fadB-2 fadA-2 fadA-2 M5M_18670 M5M_18670 M5M_18680 M5M_18680 M5M_18685 M5M_18685 M5M_18690 M5M_18690 M5M_19170 M5M_19170 M5M_19180 M5M_19180
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
fadBMultifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (716 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (392 aa)
M5M_01880Diguanylate cyclase; COG2199 FOG: GGDEF domain. (674 aa)
M5M_01885COG1960 Acyl-CoA dehydrogenases. (389 aa)
M5M_01890Carbamoyl-phosphate synthase L chain, ATP-binding protein; COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (672 aa)
M5M_01895COG1024 Enoyl-CoA hydratase/carnithine racemase. (271 aa)
M5M_01900COG1960 Acyl-CoA dehydrogenases. (386 aa)
M5M_01905COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (534 aa)
M5M_01910Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (296 aa)
M5M_01915Hypothetical protein. (284 aa)
M5M_01920COG1309 Transcriptional regulator. (195 aa)
M5M_01990COG1012 NAD-dependent aldehyde dehydrogenases. (496 aa)
M5M_01995Beta alanine--pyruvate transaminase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
M5M_02030Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (544 aa)
M5M_02035COG2086 Electron transfer flavoprotein, beta subunit. (249 aa)
M5M_02040COG2025 Electron transfer flavoprotein, alpha subunit. (309 aa)
M5M_03570Beta alanine--pyruvate transaminase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (435 aa)
M5M_03955Permease; COG2610 H+/gluconate symporter and related permeases. (433 aa)
M5M_03960Putative D--3-hydroxybutyrate oligomer hydrolase lipoprotein transmembrane. (673 aa)
M5M_03975COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (262 aa)
M5M_04880COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (673 aa)
M5M_04885enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase. (289 aa)
M5M_06335Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (272 aa)
M5M_06340enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase. (254 aa)
M5M_06345GCN5-related N-acetyltransferase; COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (167 aa)
M5M_06350Hypothetical protein. (129 aa)
M5M_06355Amidohydrolase; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (554 aa)
M5M_06395PHB depolymerase family esterase; COG3509 Poly(3-hydroxybutyrate) depolymerase. (666 aa)
M5M_08340COG1960 Acyl-CoA dehydrogenases. (396 aa)
M5M_08490L-carnitine dehydratase/bile acid-inducible protein F; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family. (383 aa)
M5M_084953-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (664 aa)
M5M_08500Fatty oxidation complex, alpha subunit. (43 aa)
M5M_08505COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
M5M_08510COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
M5M_08515Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
M5M_08520Dehydratase; COG2030 Acyl dehydratase. (152 aa)
M5M_08525COG1960 Acyl-CoA dehydrogenases. (599 aa)
M5M_08535Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase. (221 aa)
M5M_08540COG1960 Acyl-CoA dehydrogenases. (403 aa)
M5M_08545COG3173 Predicted aminoglycoside phosphotransferase. (345 aa)
M5M_08550Zinc-containing alcohol dehydrogenase superfamily protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (322 aa)
M5M_08555Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (255 aa)
M5M_08560Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (258 aa)
M5M_09945COG1960 Acyl-CoA dehydrogenases. (595 aa)
M5M_10055COG0789 Predicted transcriptional regulators. (122 aa)
M5M_10060COG1960 Acyl-CoA dehydrogenases. (389 aa)
M5M_10065COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (535 aa)
M5M_10070COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
M5M_10075COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. (667 aa)
M5M_10080hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (306 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (644 aa)
M5M_10610COG1012 NAD-dependent aldehyde dehydrogenases. (505 aa)
M5M_10615COG1960 Acyl-CoA dehydrogenases. (388 aa)
M5M_10620COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
M5M_10630Enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase. (369 aa)
M5M_10635COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Belongs to the HIBADH-related family. (296 aa)
M5M_13850COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (623 aa)
M5M_14105COG1960 Acyl-CoA dehydrogenases. (381 aa)
M5M_15125COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
M5M_15130acetoacetyl-coA reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (247 aa)
M5M_15135COG4553 Poly-beta-hydroxyalkanoate depolymerase. (403 aa)
M5M_15140Response regulator receiver. (117 aa)
M5M_15145Polyhydroxyalkanoate synthesis repressor PhaR; COG5394 Uncharacterized protein conserved in bacteria. (146 aa)
M5M_15147Poly-beta-hydroxybutyrate polymerase; COG3243 Poly(3-hydroxyalkanoate) synthetase. (575 aa)
M5M_15160COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
M5M_16255Thioesterase superfamily protein; COG0824 Predicted thioesterase. (156 aa)
M5M_16260COG1454 Alcohol dehydrogenase, class IV. (386 aa)
M5M_16265COG1960 Acyl-CoA dehydrogenases. (586 aa)
M5M_16270COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (307 aa)
M5M_16840COG1024 Enoyl-CoA hydratase/carnithine racemase. (263 aa)
M5M_17725Phosphoryl transfer system, HPr; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
fadB-2Multifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (715 aa)
fadA-23-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (392 aa)
M5M_18670COG2153 Predicted acyltransferase. (149 aa)
M5M_18680Leucine-responsive regulatory protein; COG1522 Transcriptional regulators. (162 aa)
M5M_18685Acyl-CoA dehydrogenase-like protein; COG1960 Acyl-CoA dehydrogenases. (386 aa)
M5M_18690NAD-dependent epimerase/dehydratase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
M5M_19170COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
M5M_19180COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. (218 aa)
Your Current Organism:
Simiduia agarivorans
NCBI taxonomy Id: 1117647
Other names: S. agarivorans SA1 = DSM 21679, Simiduia agarivorans DSM 21679, Simiduia agarivorans DSM 21679 = SA1, Simiduia agarivorans SA1, Simiduia agarivorans SA1 = DSM 21679
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