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glcB glcB M5M_03200 M5M_03200 M5M_03203 M5M_03203 M5M_03685 M5M_03685 M5M_04360 M5M_04360 M5M_07145 M5M_07145 glmM glmM M5M_07525 M5M_07525 M5M_07530 M5M_07530 M5M_07535 M5M_07535 anmK anmK murQ murQ M5M_07560 M5M_07560 M5M_07565 M5M_07565 glcF glcF glcE glcE M5M_07580 M5M_07580 M5M_07585 M5M_07585 M5M_07590 M5M_07590 ddpX ddpX M5M_07605 M5M_07605 M5M_07610 M5M_07610 M5M_07615 M5M_07615 M5M_07620 M5M_07620 M5M_07630 M5M_07630 M5M_07635 M5M_07635 M5M_07640 M5M_07640 M5M_07645 M5M_07645 amiD2 amiD2 M5M_07660 M5M_07660 M5M_07665 M5M_07665 M5M_09400 M5M_09400 anmK-2 anmK-2 M5M_09410 M5M_09410 glmU glmU glmS glmS M5M_12565 M5M_12565 M5M_12570 M5M_12570 M5M_12855 M5M_12855 gph gph M5M_16835 M5M_16835 M5M_16975 M5M_16975 M5M_19430 M5M_19430 M5M_19435 M5M_19435
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa)
M5M_03200COG2224 Isocitrate lyase. (531 aa)
M5M_03203Hypothetical protein. (34 aa)
M5M_03685HAD hydrolase; COG0546 Predicted phosphatases. (218 aa)
M5M_04360BadF/BadG/BcrA/BcrD ATPase family superfamily protein; COG2971 Predicted N-acetylglucosamine kinase. (301 aa)
M5M_07145Lactate dehydrogenase-like oxidoreductase; COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa)
M5M_07525COG1737 Transcriptional regulators. (282 aa)
M5M_07530COG0591 Na+/proline symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (521 aa)
M5M_07535BadF/BadG/BcrA/BcrD type ATPase; COG2971 Predicted N-acetylglucosamine kinase. (289 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (368 aa)
murQGlucokinase regulatory protein-related protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. (305 aa)
M5M_07560Hypothetical protein. (263 aa)
M5M_07565M14 family peptidase; COG2866 Predicted carboxypeptidase. (437 aa)
glcFGlycolate oxidase iron-sulfur subunit; COG0247 Fe-S oxidoreductase. (409 aa)
glcEGlycolate oxidase FAD binding subunit; COG0277 FAD/FMN-containing dehydrogenases. (353 aa)
M5M_07580Glycolate oxidase subunit GlcD; COG0277 FAD/FMN-containing dehydrogenases. (482 aa)
M5M_07585Hypothetical protein. (390 aa)
M5M_07590Lipoprotein; COG3876 Uncharacterized protein conserved in bacteria. (385 aa)
ddpXD-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (233 aa)
M5M_07605COG1757 Na+/H+ antiporter. (463 aa)
M5M_07610Peptidase U61 LD-carboxypeptidase A; COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (341 aa)
M5M_07615Hypothetical protein; COG4771 Outer membrane receptor for ferrienterochelin and colicins. (1011 aa)
M5M_07620COG1305 Transglutaminase-like enzymes, putative cysteine proteases. (464 aa)
M5M_07630NAD(FAD)-dependent dehydrogenase. (480 aa)
M5M_07635COG1737 Transcriptional regulators. (259 aa)
M5M_07640Chloromuconate cycloisomerase; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily. (364 aa)
M5M_07645NLP/P60 protein; COG0791 Cell wall-associated hydrolases (invasion-associated proteins). (457 aa)
amiD2N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD; COG3023 Negative regulator of beta-lactamase expression. (318 aa)
M5M_07660Hypothetical protein. (250 aa)
M5M_07665Hypothetical protein. (234 aa)
M5M_09400COG0739 Membrane proteins related to metalloendopeptidases. (456 aa)
anmK-2anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa)
M5M_09410Hypothetical protein. (309 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
M5M_12565COG1189 Predicted rRNA methylase. (76 aa)
M5M_12570Ribosomal RNA methyltransferase RrmJ/FtsJ; COG1189 Predicted rRNA methylase. (169 aa)
M5M_12855Hypothetical protein. (218 aa)
gphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (224 aa)
M5M_16835COG1012 NAD-dependent aldehyde dehydrogenases. (480 aa)
M5M_16975COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (483 aa)
M5M_19430COG1820 N-acetylglucosamine-6-phosphate deacetylase. (384 aa)
M5M_19435Glutamine-fructose-6-phosphate transaminase (isomerizing); COG2222 Predicted phosphosugar isomerases. (350 aa)
Your Current Organism:
Simiduia agarivorans
NCBI taxonomy Id: 1117647
Other names: S. agarivorans SA1 = DSM 21679, Simiduia agarivorans DSM 21679, Simiduia agarivorans DSM 21679 = SA1, Simiduia agarivorans SA1, Simiduia agarivorans SA1 = DSM 21679
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