STRINGSTRING
JCM15093_857 JCM15093_857 JCM15093_3501 JCM15093_3501 JCM15093_3288 JCM15093_3288 JCM15093_3276 JCM15093_3276 pgk pgk JCM15093_3155 JCM15093_3155 JCM15093_2976 JCM15093_2976 JCM15093_2948 JCM15093_2948 JCM15093_2888 JCM15093_2888 JCM15093_2890 JCM15093_2890 JCM15093_2892 JCM15093_2892 purA purA JCM15093_3135 JCM15093_3135 JCM15093_2699 JCM15093_2699 JCM15093_2685 JCM15093_2685 JCM15093_2675 JCM15093_2675 folD folD JCM15093_2255 JCM15093_2255 nadD nadD gmk gmk murA murA JCM15093_2275 JCM15093_2275 JCM15093_2427 JCM15093_2427 purE purE pfp pfp JCM15093_2215 JCM15093_2215 nadE nadE JCM15093_2190 JCM15093_2190 guaB guaB JCM15093_2732 JCM15093_2732 xpt xpt eno eno coaE coaE JCM15093_1749 JCM15093_1749 nadK nadK JCM15093_2036 JCM15093_2036 tpiA tpiA queA-2 queA-2 pgi pgi JCM15093_1950 JCM15093_1950 JCM15093_3216 JCM15093_3216 JCM15093_3214 JCM15093_3214 pfkA-2 pfkA-2 JCM15093_3391 JCM15093_3391 thyA thyA JCM15093_1258 JCM15093_1258 glmS-2 glmS-2 JCM15093_1268 JCM15093_1268 JCM15093_1275 JCM15093_1275 purU purU JCM15093_1373 JCM15093_1373 JCM15093_1374 JCM15093_1374 JCM15093_1387 JCM15093_1387 queF queF queC queC JCM15093_1392 JCM15093_1392 JCM15093_1410 JCM15093_1410 JCM15093_2818 JCM15093_2818 fcl fcl JCM15093_809 JCM15093_809 JCM15093_628 JCM15093_628 JCM15093_617 JCM15093_617 pyrG pyrG gpmA gpmA glmS glmS JCM15093_556 JCM15093_556 carA carA JCM15093_543 JCM15093_543 JCM15093_504 JCM15093_504 JCM15093_423 JCM15093_423 pyrK pyrK JCM15093_418 JCM15093_418 JCM15093_2449 JCM15093_2449 kdsB kdsB pyrB pyrB pyrI pyrI JCM15093_3030 JCM15093_3030 JCM15093_3033 JCM15093_3033 atpH atpH atpF atpF GCA_000428125_00977 GCA_000428125_00977 JCM15093_3038 JCM15093_3038 JCM15093_3040 JCM15093_3040 atpD atpD purT purT JCM15093_3044 JCM15093_3044 JCM15093_3045 JCM15093_3045 JCM15093_3049 JCM15093_3049 JCM15093_2545 JCM15093_2545 JCM15093_2318 JCM15093_2318 JCM15093_2334 JCM15093_2334 adk adk JCM15093_2349 JCM15093_2349 nnrD nnrD coaX coaX JCM15093_1435 JCM15093_1435 guaA guaA JCM15093_1493 JCM15093_1493 JCM15093_1496 JCM15093_1496 purC purC JCM15093_1515 JCM15093_1515 pyrF pyrF JCM15093_1518 JCM15093_1518 JCM15093_1004 JCM15093_1004 surE surE JCM15093_939 JCM15093_939 JCM15093_30 JCM15093_30 JCM15093_31 JCM15093_31 pyrE pyrE ackA ackA dacA dacA JCM15093_128 JCM15093_128 JCM15093_182 JCM15093_182 JCM15093_210 JCM15093_210 JCM15093_212 JCM15093_212 gpmI gpmI purN purN pfkA pfkA JCM15093_305 JCM15093_305 apt apt JCM15093_362 JCM15093_362 JCM15093_363 JCM15093_363 JCM15093_377 JCM15093_377 nadA nadA JCM15093_1049 JCM15093_1049 queA queA queG queG purD purD coaD coaD JCM15093_1179 JCM15093_1179 JCM15093_1208 JCM15093_1208 JCM15093_1224 JCM15093_1224
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JCM15093_857Unannotated protein. (405 aa)
JCM15093_3501Unannotated protein. (293 aa)
JCM15093_3288Unannotated protein. (333 aa)
JCM15093_3276Unannotated protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (202 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (419 aa)
JCM15093_3155Unannotated protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa)
JCM15093_2976Unannotated protein. (262 aa)
JCM15093_2948Unannotated protein; Belongs to the PurH family. (507 aa)
JCM15093_2888Unannotated protein. (198 aa)
JCM15093_2890Unannotated protein. (584 aa)
JCM15093_2892Unannotated protein. (438 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
JCM15093_3135Unannotated protein. (305 aa)
JCM15093_2699Unannotated protein. (397 aa)
JCM15093_2685Unannotated protein. (1234 aa)
JCM15093_2675Unannotated protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (288 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
JCM15093_2255Unannotated protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (379 aa)
nadDUnannotated protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (193 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (189 aa)
murAUnannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa)
JCM15093_2275Unannotated protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (153 aa)
JCM15093_2427Unannotated protein; Belongs to the ribF family. (308 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
pfpUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (548 aa)
JCM15093_2215Unannotated protein. (448 aa)
nadEUnannotated protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (643 aa)
JCM15093_2190Unannotated protein. (201 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
JCM15093_2732Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)
xptUnannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
coaEUnannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (193 aa)
JCM15093_1749Unannotated protein. (177 aa)
nadKUnannotated protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (290 aa)
JCM15093_2036Unannotated protein; Belongs to the NDK family. (154 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (694 aa)
queA-2Unannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (408 aa)
pgiUnannotated protein; Belongs to the GPI family. (445 aa)
JCM15093_1950Unannotated protein. (209 aa)
JCM15093_3216Unannotated protein. (322 aa)
JCM15093_3214Unannotated protein. (366 aa)
pfkA-2Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (326 aa)
JCM15093_3391Unannotated protein. (229 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
JCM15093_1258Unannotated protein. (437 aa)
glmS-2Unannotated protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (616 aa)
JCM15093_1268Unannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (329 aa)
JCM15093_1275Unannotated protein. (419 aa)
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
JCM15093_1373Unannotated protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (159 aa)
JCM15093_1374Unannotated protein. (261 aa)
JCM15093_1387Unannotated protein; Belongs to the NadC/ModD family. (279 aa)
queFUnannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (154 aa)
queCUnannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (220 aa)
JCM15093_1392Unannotated protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (226 aa)
JCM15093_1410Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)
JCM15093_2818Unannotated protein; Belongs to the 5'-nucleotidase family. (579 aa)
fclUnannotated protein; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (347 aa)
JCM15093_809Unannotated protein. (360 aa)
JCM15093_628Unannotated protein; Belongs to the UPF0301 (AlgH) family. (207 aa)
JCM15093_617Unannotated protein. (230 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (229 aa)
glmSUnannotated protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa)
JCM15093_556Unannotated protein. (627 aa)
carAUnannotated protein; Belongs to the CarA family. (361 aa)
JCM15093_543Unannotated protein. (376 aa)
JCM15093_504Unannotated protein. (438 aa)
JCM15093_423Unannotated protein. (258 aa)
pyrKUnannotated protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa)
JCM15093_418Unannotated protein; Belongs to the dihydroorotate dehydrogenase family. (303 aa)
JCM15093_2449Unannotated protein; Belongs to the CinA family. (168 aa)
kdsBUnannotated protein; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (252 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
pyrIUnannotated protein; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
JCM15093_3030Unannotated protein. (292 aa)
JCM15093_3033Unannotated protein. (528 aa)
atpHUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (186 aa)
atpFUnannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (166 aa)
GCA_000428125_00977Unannotated protein. (85 aa)
JCM15093_3038Unannotated protein. (363 aa)
JCM15093_3040Unannotated protein. (79 aa)
atpDUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (503 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (388 aa)
JCM15093_3044Unannotated protein. (505 aa)
JCM15093_3045Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (737 aa)
JCM15093_3049Unannotated protein. (417 aa)
JCM15093_2545Unannotated protein; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa)
JCM15093_2318Unannotated protein. (84 aa)
JCM15093_2334Unannotated protein. (188 aa)
adkUnannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (189 aa)
JCM15093_2349Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
nnrDUnannotated protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (504 aa)
coaXUnannotated protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (243 aa)
JCM15093_1435Unannotated protein. (261 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (507 aa)
JCM15093_1493Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
JCM15093_1496Unannotated protein. (149 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (313 aa)
JCM15093_1515Unannotated protein. (388 aa)
pyrFUnannotated protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. (274 aa)
JCM15093_1518Unannotated protein. (408 aa)
JCM15093_1004Unannotated protein. (182 aa)
surEUnannotated protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
JCM15093_939Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (747 aa)
JCM15093_30Unannotated protein. (292 aa)
JCM15093_31Unannotated protein. (256 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (211 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
dacAUnannotated protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (254 aa)
JCM15093_128Unannotated protein. (310 aa)
JCM15093_182Unannotated protein. (551 aa)
JCM15093_210Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (146 aa)
JCM15093_212Unannotated protein. (441 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (336 aa)
JCM15093_305Unannotated protein. (206 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa)
JCM15093_362Unannotated protein. (113 aa)
JCM15093_363Unannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (296 aa)
JCM15093_377Unannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
nadAUnannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (330 aa)
JCM15093_1049Unannotated protein; Catalyzes the oxidation of L-aspartate to iminoaspartate. (523 aa)
queAUnannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (351 aa)
queGUnannotated protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (330 aa)
purDUnannotated protein; Belongs to the GARS family. (424 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (150 aa)
JCM15093_1179Unannotated protein; Belongs to the pyruvate kinase family. (484 aa)
JCM15093_1208Unannotated protein. (217 aa)
JCM15093_1224Unannotated protein. (184 aa)
Your Current Organism:
Bacteroides graminisolvens
NCBI taxonomy Id: 1121097
Other names: B. graminisolvens DSM 19988 = JCM 15093, Bacteroides graminisolvens DSM 19988, Bacteroides graminisolvens DSM 19988 = JCM 15093, Bacteroides graminisolvens JCM 15093, Bacteroides graminisolvens JCM 15093 = DSM 19988
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