STRINGSTRING
secY secY ctsF ctsF ctsE ctsE ctsD ctsD ctsG ctsG tssM tssM tssD tssD tssL tssL tssJ tssJ tssI2 tssI2 secG secG secE secE CCUN_0710 CCUN_0710 CCUN_0712 CCUN_0712 CCUN_0713 CCUN_0713 oxaA oxaA secA secA ffh ffh tatC tatC tatB tatB CCUN_1406 CCUN_1406 ftsY ftsY tatA tatA CCUN_1552 CCUN_1552 CCUN_1554 CCUN_1554 yajC yajC secD secD secF secF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (421 aa)
ctsFTransformation system, type II secretion system membrane protein CtsF. (395 aa)
ctsETransformation system, type II secretion system ATPase CtsE. (536 aa)
ctsDTransformation system, type II secretion system secretin protein CtsD. (471 aa)
ctsGTransformation system, putative pseudopilin protein CtsG. (171 aa)
tssMType VI secretion system, membrane platform protein. (1175 aa)
tssDType VI secretion system, secreted hemolysin co-regulated protein (Hcp). (171 aa)
tssLType VI secretion system, membrane platform protein. (257 aa)
tssJType VI secretion system, membrane platform protein. (148 aa)
tssI2Type VI secretion system, secreted protein. (819 aa)
secGProtein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (119 aa)
secEProtein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (59 aa)
CCUN_0710Conjugal transfer protein VirB8. (219 aa)
CCUN_0712Conjugal transfer protein TrbL/VirB6. (336 aa)
CCUN_0713Uncharacterized protein. (102 aa)
oxaAMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (533 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (861 aa)
ffhSignal recognition particle protein. (445 aa)
tatCSec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (243 aa)
tatBSec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (152 aa)
CCUN_1406Putative type II secretion system protein. (159 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (287 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (77 aa)
CCUN_1552Type IV secretion system, coupling protein VirD4. (610 aa)
CCUN_1554Type IV secretion system protein VirB11. (316 aa)
yajCSec translocon accessory complex subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (81 aa)
secDProtein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (526 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (323 aa)
Your Current Organism:
Campylobacter cuniculorum
NCBI taxonomy Id: 1121267
Other names: C. cuniculorum DSM 23162 = LMG 24588, Campylobacter cuniculorum 150B, Campylobacter cuniculorum DSM 23162, Campylobacter cuniculorum DSM 23162 = LMG 24588, Campylobacter cuniculorum LMG 24588, Campylobacter cuniculorum LMG 24588 = DSM 23162, Campylobacter sp. 150B
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