(27 nodes) Mixed, incl. Sulfur amino acid biosynthetic process, and L-serine biosynthetic process network (Chitinimonas taiwanensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFZ70247.1	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1234 aa)
	metK	Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa)
	ahcY	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (469 aa)
	SFZ70323.1	5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (280 aa)
	SFZ72197.1	Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (295 aa)
	metZ	O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa)
	cysS	cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (458 aa)
	SFZ75063.1	Phosphoserine phosphatase. (284 aa)
	SFZ76401.1	Glyoxylate/hydroxypyruvate reductase A. (307 aa)
	SFZ76732.1	L-threonine synthase. (470 aa)
	SFZ76734.1	Hypothetical protein. (389 aa)
	SFZ76736.1	Homoserine dehydrogenase. (441 aa)
	SFZ76738.1	Acetyltransferase (GNAT) domain-containing protein. (150 aa)
	SFZ76740.1	Alanine-synthesizing transaminase. (408 aa)
	SFZ76742.1	Uncharacterized conserved protein, contains Mth938-like domain. (132 aa)
	ilvA	L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
	metE	Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (780 aa)
	SFZ78503.1	Hypothetical protein. (136 aa)
	serC	Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
	SFZ78823.1	Cystathionine gamma-lyase. (384 aa)
	SFZ78825.1	Cystathionine beta-synthase. (455 aa)
	SFZ78876.1	Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (216 aa)
	SFZ79149.1	Phosphoserine phosphatase. (456 aa)
	SFZ79160.1	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa)
	SFZ79168.1	Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
	SFZ79245.1	Serine O-acetyltransferase. (250 aa)
	SFZ79256.1	Protein of unknown function. (76 aa)

Your Current Organism:

Chitinimonas taiwanensis

NCBI taxonomy Id: 1121279
Other names: C. taiwanensis DSM 18899, Chitinimonas taiwanensis DSM 18899

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFZ70247.1	SFZ70323.1	SAMN02745887_00123	SAMN02745887_00164	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family.	0.997
SFZ70247.1	SFZ72197.1	SAMN02745887_00123	SAMN02745887_00553	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.815
SFZ70247.1	SFZ75063.1	SAMN02745887_00123	SAMN02745887_01441	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Phosphoserine phosphatase.	0.800
SFZ70247.1	SFZ76401.1	SAMN02745887_00123	SAMN02745887_01939	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Glyoxylate/hydroxypyruvate reductase A.	0.696
SFZ70247.1	SFZ76732.1	SAMN02745887_00123	SAMN02745887_02097	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	L-threonine synthase.	0.695
SFZ70247.1	SFZ76736.1	SAMN02745887_00123	SAMN02745887_02099	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Homoserine dehydrogenase.	0.904
SFZ70247.1	SFZ76740.1	SAMN02745887_00123	SAMN02745887_02101	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Alanine-synthesizing transaminase.	0.792
SFZ70247.1	SFZ78503.1	SAMN02745887_00123	SAMN02745887_03028	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Hypothetical protein.	0.673
SFZ70247.1	SFZ78823.1	SAMN02745887_00123	SAMN02745887_03219	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Cystathionine gamma-lyase.	0.939
SFZ70247.1	SFZ78825.1	SAMN02745887_00123	SAMN02745887_03220	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Cystathionine beta-synthase.	0.826
SFZ70247.1	SFZ78876.1	SAMN02745887_00123	SAMN02745887_03232	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family.	0.770
SFZ70247.1	SFZ79149.1	SAMN02745887_00123	SAMN02745887_03403	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Phosphoserine phosphatase.	0.828
SFZ70247.1	SFZ79168.1	SAMN02745887_00123	SAMN02745887_03414	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.815
SFZ70247.1	SFZ79245.1	SAMN02745887_00123	SAMN02745887_03465	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Serine O-acetyltransferase.	0.770
SFZ70247.1	SFZ79256.1	SAMN02745887_00123	SAMN02745887_03471	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Protein of unknown function.	0.796
SFZ70247.1	ahcY	SAMN02745887_00123	SAMN02745887_00160	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.916
SFZ70247.1	cysS	SAMN02745887_00123	SAMN02745887_00720	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.740
SFZ70247.1	ilvA	SAMN02745887_00123	SAMN02745887_02210	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.841
SFZ70247.1	metE	SAMN02745887_00123	SAMN02745887_03024	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.939
SFZ70247.1	metK	SAMN02745887_00123	SAMN02745887_00156	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.916