STRINGSTRING
AGC67073.1 AGC67073.1 AGC67076.1 AGC67076.1 gcdB gcdB OadG OadG nifJ1 nifJ1 leuC1 leuC1 icd icd kynB kynB pckG pckG leuA1 leuA1 AGC68096.1 AGC68096.1 pycB pycB prpC prpC AGC68158.1 AGC68158.1 rsmI rsmI oadB oadB AGC68228.1 AGC68228.1 AGC68235.1 AGC68235.1 AGC68236.1 AGC68236.1 AGC68237.1 AGC68237.1 AGC68238.1 AGC68238.1 AGC68239.1 AGC68239.1 vorB vorB vorA vorA korC korC ilvK ilvK pta pta ackA ackA ilvC ilvC ilvH ilvH ilvD ilvD ilvB ilvB leuB leuB leuD leuD leuC leuC nifJ2 nifJ2 leuA2 leuA2 adhE adhE ppdK ppdK ldh ldh alkH alkH gltA gltA Mae Mae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGC67073.1Flavin oxidoreductase/NADH oxidase. (442 aa)
AGC67076.1Fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (651 aa)
gcdBglutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (395 aa)
OadGOxaloacetate decarboxylase, gamma chain. (121 aa)
nifJ1Pyruvate-flavodoxin oxidoreductase NifJ. (1177 aa)
leuC13-isopropylmalate dehydratase large subunit 1. (661 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
kynBKynurenine formamidase KynB. (223 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (603 aa)
leuA12-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (555 aa)
AGC68096.1Biotin/lipoyl attachment domain-containing protein. (140 aa)
pycBPyruvate carboxylase subunit B. (464 aa)
prpC2-methylcitrate synthase PrpC; Belongs to the citrate synthase family. (457 aa)
AGC68158.1Putative fumarate hydratase subunit alpha. (281 aa)
rsmIRibosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (300 aa)
oadBOxaloacetate decarboxylase beta chain; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (420 aa)
AGC68228.1Cyclase family protein. (206 aa)
AGC68235.1Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa)
AGC68236.1Methyltransferase type 11; Belongs to the methyltransferase superfamily. (240 aa)
AGC68237.1Tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit. (183 aa)
AGC68238.1Hypothetical protein. (229 aa)
AGC68239.1Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit; Chain I. (68 aa)
vorBKetoisovalerate oxidoreductase subunit VorB. (357 aa)
vorAKetoisovalerate oxidoreductase subunit VorA. (248 aa)
korC2-oxoglutarate synthase subunit KorC. (177 aa)
ilvKBranched-chain-amino-acid aminotransferase 2. (353 aa)
ptaPhosphate acetyltransferase Pta. (330 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
ilvHAcetolactate synthase small subunit IlvH. (162 aa)
ilvDDihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (552 aa)
ilvBAcetolactate synthase large subunit IlvB. (556 aa)
leuB3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuD3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
leuC3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa)
nifJ2Pyruvate-flavodoxin oxidoreductase NifJ. (1171 aa)
leuA22-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (517 aa)
adhEAldehyde-alcohol dehydrogenase AdhE; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (905 aa)
ppdKPyruvate, phosphate dikinase PpdK; Belongs to the PEP-utilizing enzyme family. (879 aa)
ldhL-lactate dehydrogenase Ldh; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
alkHNAD-dependent aldehyde dehydrogenase AlkH; Belongs to the aldehyde dehydrogenase family. (456 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (465 aa)
MaeNAD-dependent malic enzyme. (390 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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