STRINGSTRING
lytS lytS AGC67093.1 AGC67093.1 yycG yycG ispE ispE AGC67167.1 AGC67167.1 AGC67189.1 AGC67189.1 AGC67243.1 AGC67243.1 cssS cssS cysC cysC dagK dagK mcsB mcsB glxK glxK glcK glcK AGC67335.1 AGC67335.1 pleD pleD yesM1 yesM1 AGC67516.1 AGC67516.1 dpiB dpiB spoIIIAH spoIIIAH AGC67655.1 AGC67655.1 AGC67672.1 AGC67672.1 pfp pfp cheA1 cheA1 folK folK AGC67769.1 AGC67769.1 Gck1 Gck1 rhaB rhaB AGC67905.1 AGC67905.1 xylB1 xylB1 AGC67939.1 AGC67939.1 coaE coaE AGC67970.1 AGC67970.1 AGC68043.1 AGC68043.1 glpK1 glpK1 ribF ribF AGC68091.1 AGC68091.1 AGC68100.1 AGC68100.1 AGC68156.1 AGC68156.1 AGC68164.1 AGC68164.1 lacC lacC tmk tmk ackA ackA lysC lysC aroK aroK sps11 sps11 pyrH pyrH relA relA prs prs spoIIAB spoIIAB hprK hprK arlS arlS pfkA pfkA cmk cmk degS degS AGC68548.1 AGC68548.1 araB araB yesM2 yesM2 AGC68619.1 AGC68619.1 phoR1 phoR1 AGC68679.1 AGC68679.1 dltS dltS cheA2 cheA2 cheA3 cheA3 thiDE1 thiDE1 thiDE2 thiDE2 thiM thiM AGC68860.1 AGC68860.1 phoR2 phoR2 ppdK ppdK gmk gmk thiN thiN sps12 sps12 pgk pgk AGC69084.1 AGC69084.1 pfkA2 pfkA2 walK walK AGC69199.1 AGC69199.1 ppnK ppnK AGC69219.1 AGC69219.1 AGC69237.1 AGC69237.1 galK galK pyk pyk AGC69310.1 AGC69310.1 AGC69314.1 AGC69314.1 AGC69370.1 AGC69370.1 AGC69372.1 AGC69372.1 prsA prsA kdgK kdgK proB proB adk adk AGC69599.1 AGC69599.1 AGC69606.1 AGC69606.1 coaX coaX AGC69628.1 AGC69628.1 argB argB glpK glpK AGC69705.1 AGC69705.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lytSSensor protein LytS. (599 aa)
AGC67093.1Integral membrane sensor signal transduction histidine kinase. (594 aa)
yycGSensor histidine kinase YycG. (483 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (319 aa)
AGC67167.1Exopolysaccharide biosynthesis-like protein. (444 aa)
AGC67189.1Integral membrane sensor signal transduction histidine kinase. (161 aa)
AGC67243.1Integral membrane sensor signal transduction histidine kinase. (603 aa)
cssSSensor histidine kinase CssS. (344 aa)
cysCAdenylyl-sulfate kinase CysC; Catalyzes the synthesis of activated sulfate. (199 aa)
dagKDiacylglycerol kinase DagK. (294 aa)
mcsBPutative ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins. (346 aa)
glxKGlycerate kinase GlxK; Belongs to the glycerate kinase type-1 family. (378 aa)
glcKGlucokinase GlcK. (320 aa)
AGC67335.1Hypothetical protein. (169 aa)
pleDResponse regulator PleD. (404 aa)
yesM1Putative two-component sensor kinase YesM. (613 aa)
AGC67516.1Signal transduction histidine kinase, LytS. (581 aa)
dpiBHistidine kinase-like ATPase DpiB. (422 aa)
spoIIIAHDiacylglycerol kinase. (126 aa)
AGC67655.1Putative anti-sigma regulatory factor, serine/threonine protein kinase. (141 aa)
AGC67672.1Integral membrane sensor signal transduction histidine kinase. (594 aa)
pfpPyrophosphate--fructose 6-phosphate 1-phosphotransferase Pfp; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (416 aa)
cheA1Chemotaxis protein CheA. (683 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK. (175 aa)
AGC67769.1PAS/PAC sensor signal transduction histidine kinase. (556 aa)
Gck1PfkB domain protein. (366 aa)
rhaBRhamnulokinase RhaB. (497 aa)
AGC67905.1Putative sensor histidine kinase. (303 aa)
xylB1Xylulose kinase XylB. (508 aa)
AGC67939.1Histidine kinase. (186 aa)
coaEdephospho-CoA kinase CoaE; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa)
AGC67970.1Two-component system signal transduction histidine kinase. (640 aa)
AGC68043.1Putative xylose repressor. (379 aa)
glpK1Glycerol kinase 1. (434 aa)
ribFBifunctional riboflavin kinase/FMN adenylyltransferase RibF; Belongs to the ribF family. (322 aa)
AGC68091.1Phage shock protein C-like protein. (138 aa)
AGC68100.1PAS/PAC sensor signal transduction histidine kinase. (308 aa)
AGC68156.1Fumble domain protein. (279 aa)
AGC68164.1Integral membrane sensor signal transduction histidine kinase. (489 aa)
lacCTagatose-6-phosphate kinase LacC; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (314 aa)
tmkThymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
lysCAspartokinase LysC; Belongs to the aspartokinase family. (451 aa)
aroKShikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa)
sps11Serine/threonine-protein kinase Sps1. (470 aa)
pyrHUridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
relAGTP pyrophosphokinase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (759 aa)
prsRibose-phosphate pyrophosphokinase Prs. (318 aa)
spoIIABAnti-sigma F factor SpoIIAB; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (142 aa)
hprKHPr kinase/phosphorylase HprK; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable c [...] (319 aa)
arlSSignal transduction histidine-protein kinase ArlS. (499 aa)
pfkA6-phosphofructokinase PfkA; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
cmkCytidylate kinase Cmk. (224 aa)
degSSensor protein DegS. (382 aa)
AGC68548.1Putative stress-responsive transcriptional regulator. (66 aa)
araBRibulokinase AraB. (558 aa)
yesM2Sensor histidine kinase YesM. (611 aa)
AGC68619.1Hypothetical protein. (356 aa)
phoR1Alkaline phosphatase synthesis sensor protein PhoR. (351 aa)
AGC68679.1Multi-sensor signal transduction histidine kinase. (594 aa)
dltSSensor protein DltS. (408 aa)
cheA2Chemotaxis protein CheA. (770 aa)
cheA3Chemotaxis protein CheA. (696 aa)
thiDE1Thiamine biosynthesis bifunctional protein ThiED. (264 aa)
thiDE2Thiamine biosynthesis bifunctional protein ThiED. (261 aa)
thiMHydroxyethylthiazole kinase ThiM; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (278 aa)
AGC68860.1Aminoglycoside phosphotransferase. (249 aa)
phoR2Alkaline phosphatase synthesis sensor protein PhoR. (351 aa)
ppdKPyruvate, phosphate dikinase PpdK; Belongs to the PEP-utilizing enzyme family. (879 aa)
gmkGuanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (190 aa)
thiNThiamine pyrophosphokinase ThiN. (211 aa)
sps12Serine/threonine-protein kinase Sps1. (668 aa)
pgkPhosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (400 aa)
AGC69084.1Phosphoribulokinase/uridine kinase. (552 aa)
pfkA26-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate, the first committing step of glycolysis. (363 aa)
walKSensor protein kinase WalK. (555 aa)
AGC69199.1Integral membrane sensor signal transduction histidine kinase. (612 aa)
ppnKInorganic polyphosphate/ATP-NAD kinase PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa)
AGC69219.1Hypothetical protein. (320 aa)
AGC69237.1RelA/SpoT domain-containing protein. (222 aa)
galKGalactokinase GalK; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (394 aa)
pykPyruvate kinase Pyk; Belongs to the pyruvate kinase family. (587 aa)
AGC69310.1Two component system histidine kinase. (590 aa)
AGC69314.1Universal stress protein domain-containing protein. (125 aa)
AGC69370.1Anti-sigma regulatory factor; Ser/Thr protein kinase. (143 aa)
AGC69372.1Anti-sigma regulatory factor; Ser/Thr protein kinase. (132 aa)
prsARibose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
kdgK2-keto-3-deoxygluconate kinase KdgK. (357 aa)
proBGlutamate 5-kinase ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (285 aa)
adkAdenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
AGC69599.1Putative ATP/GTP hydrolase. (148 aa)
AGC69606.1Integral membrane sensor signal transduction histidine kinase. (627 aa)
coaXType III pantothenate kinase CoaX; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (256 aa)
AGC69628.1Sensor signal transduction histidine kinase. (582 aa)
argBAcetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
glpKGlycerol kinase GlpK; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (497 aa)
AGC69705.1Multi-sensor signal transduction histidine kinase. (601 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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