STRINGSTRING
AGC67047.1 AGC67047.1 MtlD MtlD AGC67073.1 AGC67073.1 fabG1 fabG1 AGC67076.1 AGC67076.1 nrdD nrdD nrdG nrdG Adh1 Adh1 dkgA dkgA dus1 dus1 AGC67181.1 AGC67181.1 capL capL AGC67262.1 AGC67262.1 hom hom hprA hprA AGC67495.1 AGC67495.1 ahpC ahpC trxB1 trxB1 NfnB NfnB NfnA NfnA rutF1 rutF1 pyrK pyrK pyrD pyrD AGC67669.1 AGC67669.1 nifJ1 nifJ1 bdhA bdhA msrA msrA icd icd iorA iorA iorB iorB lplD lplD Adh3 Adh3 lpdA lpdA srlD srlD kduD kduD fabI fabI nuoE nuoE nuoF2 nuoF2 FhbC FhbC gcvPA gcvPA gcvPB gcvPB AGC67988.1 AGC67988.1 gdhA gdhA AGC68004.1 AGC68004.1 AGC68006.1 AGC68006.1 tdh tdh sodF sodF hcp hcp AGC68136.1 AGC68136.1 guaB guaB serA serA fabG2 fabG2 dapB dapB asd asd trxA trxA zwf zwf vorB vorB korC korC AGC68262.1 AGC68262.1 aroE1 aroE1 aroE2 aroE2 queH queH ilvC ilvC leuB leuB murB murB AGC68412.1 AGC68412.1 cbrA cbrA ispG ispG dxr dxr nifJ2 nifJ2 folD folD AGC68455.1 AGC68455.1 proC proC ispH ispH AGC68502.1 AGC68502.1 egsA1 egsA1 proA proA acoA acoA egsA2 egsA2 egsA3 egsA3 nox nox AGC68657.1 AGC68657.1 Fdx2 Fdx2 rbr rbr ddh1 ddh1 AGC68722.1 AGC68722.1 sDR sDR AGC68734.1 AGC68734.1 AGC68761.1 AGC68761.1 gltB gltB AGC68763.1 AGC68763.1 AGC68777.1 AGC68777.1 AGC68808.1 AGC68808.1 norV norV AGC68826.1 AGC68826.1 AGC68828.1 AGC68828.1 rutF2 rutF2 nasD nasD FhmC FhmC FhmD FhmD adhE adhE AGC68866.1 AGC68866.1 nifH1 nifH1 AGC68903.1 AGC68903.1 ddh2 ddh2 cooS1 cooS1 nifE nifE nifK nifK nifH2 nifH2 hemN hemN gapA gapA spoVFA spoVFA AGC69077.1 AGC69077.1 folA folA ldh ldh cotJC1 cotJC1 cotJC2 cotJC2 AGC69122.1 AGC69122.1 AGC69125.1 AGC69125.1 alkH alkH Adh6 Adh6 AGC69208.1 AGC69208.1 AGC69269.1 AGC69269.1 AGC69276.1 AGC69276.1 tyrA tyrA AGC69316.1 AGC69316.1 AGC69346.1 AGC69346.1 rnfB rnfB rnfA rnfA rnfG rnfG rnfD rnfD rnfC rnfC NfhA NfhA NfhB NfhB AGC69392.1 AGC69392.1 AGC69398.1 AGC69398.1 AGC69399.1 AGC69399.1 hisD hisD AGC69443.1 AGC69443.1 AGC69467.1 AGC69467.1 AGC69472.1 AGC69472.1 gnd gnd trxB2 trxB2 AGC69503.1 AGC69503.1 AGC69506.1 AGC69506.1 AGC69544.1 AGC69544.1 AGC69551.1 AGC69551.1 rbr1 rbr1 argC argC nadB1 nadB1 Mae Mae mdh mdh AGC69672.1 AGC69672.1 nrdZ nrdZ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGC67047.1Extradiol ring-cleavage dioxygenase, class III protein, subunit B. (461 aa)
MtlDOxidoreductase. (538 aa)
AGC67073.1Flavin oxidoreductase/NADH oxidase. (442 aa)
fabG13-oxoacyl-[acyl-carrier-protein] reductase FabG. (255 aa)
AGC67076.1Fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (651 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase NrdD. (823 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (169 aa)
Adh1Extracellular protein. (353 aa)
dkgA2,5-diketo-D-gluconic acid reductase A. (338 aa)
dus1tRNA-dihydrouridine synthase 1; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (324 aa)
AGC67181.1Coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein. (396 aa)
capLProtein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (436 aa)
AGC67262.1Flavin reductase-like protein. (174 aa)
homHomoserine dehydrogenase Hom. (423 aa)
hprAGlycerate dehydrogenase HprA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
AGC67495.12,5-didehydrogluconate reductase. (278 aa)
ahpCAlkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
trxB1Thioredoxin reductase TrxB. (541 aa)
NfnBOxidoreductase FAD/NAD(P)-binding domain protein. (281 aa)
NfnANADPH-dependent glutamate synthase. (465 aa)
rutF1NADPH-dependent FMN reductase RutF. (206 aa)
pyrKDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit PyrK; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit PyrD; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
AGC67669.1Class II aldolase/adducin family protein. (348 aa)
nifJ1Pyruvate-flavodoxin oxidoreductase NifJ. (1177 aa)
bdhANADH-dependent butanol dehydrogenase A. (388 aa)
msrAPeptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (173 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
iorAIndolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (582 aa)
iorBIndolepyruvate oxidoreductase subunit IorB. (196 aa)
lplDPutative glucosidase LplD. (462 aa)
Adh3Alcohol dehydrogenase, zinc-binding domain protein. (421 aa)
lpdADihydrolipoyl dehydrogenase LpdA. (456 aa)
srlDSorbitol-6-phosphate 2-dehydrogenase SrlD. (258 aa)
kduD2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD. (253 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH] FabI. (255 aa)
nuoENADH-quinone oxidoreductase subunit E. (165 aa)
nuoF2NADH-quinone oxidoreductase subunit F 2. (597 aa)
FhbCFe only hydrogenase 1. (587 aa)
gcvPAGlycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (446 aa)
gcvPBGlycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (488 aa)
AGC67988.1Hypothetical protein. (116 aa)
gdhAGlutamate dehydrogenase GdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (422 aa)
AGC68004.1FAD dependent oxidoreductase. (521 aa)
AGC68006.1Hypothetical protein. (396 aa)
tdhL-threonine 3-dehydrogenase Tdh. (399 aa)
sodFSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (212 aa)
hcpHydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (520 aa)
AGC68136.1Hypothetical protein. (167 aa)
guaBInosine-5'-monophosphate dehydrogenase GuaB. (497 aa)
serAD-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa)
fabG23-oxoacyl-[acyl-carrier-protein] reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa)
trxAThioredoxin-1; Belongs to the thioredoxin family. (108 aa)
zwfGlucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (510 aa)
vorBKetoisovalerate oxidoreductase subunit VorB. (357 aa)
korC2-oxoglutarate synthase subunit KorC. (177 aa)
AGC68262.1Hypothetical protein. (380 aa)
aroE1Shikimate dehydrogenase AroE. (295 aa)
aroE2Shikimate dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (188 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
leuB3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase MurB; Cell wall formation. (306 aa)
AGC68412.1Amine oxidase. (432 aa)
cbrAProtein CbrA. (354 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (399 aa)
nifJ2Pyruvate-flavodoxin oxidoreductase NifJ. (1171 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
AGC68455.1Hypothetical protein. (103 aa)
proCPyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (678 aa)
AGC68502.1Flavoprotein. (408 aa)
egsA1Glycerol-1-phosphate dehydrogenase [NAD(P)+]. (456 aa)
proAGamma-glutamyl phosphate reductase ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa)
acoAAcetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (321 aa)
egsA2Glycerol-1-phosphate dehydrogenase [NAD(P)+]. (450 aa)
egsA3Glycerol-1-phosphate dehydrogenase [NAD(P)+]. (456 aa)
noxNADH oxidase Nox. (543 aa)
AGC68657.1Flavoprotein, HI0933 family. (413 aa)
Fdx2Ferredoxin. (65 aa)
rbrRubrerythrin. (220 aa)
ddh1D-2-hydroxyacid dehydrogenase Ddh; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
AGC68722.1NADPH-dependent FMN reductase. (189 aa)
sDRShort-chain dehydrogenase/reductase SDR. (262 aa)
AGC68734.1Flavodoxin domain-containing protein. (161 aa)
AGC68761.1Glutamate synthase (NADPH) GltB3 subunit. (238 aa)
gltBGlutamate synthase GltB; Belongs to the glutamate synthase family. (501 aa)
AGC68763.1Glutamate synthase (NADPH) GltB1 subunit. (377 aa)
AGC68777.1Saccharopine dehydrogenase. (399 aa)
AGC68808.1Pyridoxamine 5'-phosphate oxidase domain-containing protein, FMN-binding protein. (130 aa)
norVAnaerobic nitric oxide reductase flavorubredoxin NorV. (407 aa)
AGC68826.1ArsC family protein; Belongs to the ArsC family. (118 aa)
AGC68828.1Hypothetical protein. (292 aa)
rutF2NADPH-dependent FMN reductase RutF. (212 aa)
nasDNitrite reductase [NAD(P)H]. (408 aa)
FhmCHypothetical protein. (98 aa)
FhmDHypothetical protein. (80 aa)
adhEAldehyde-alcohol dehydrogenase AdhE; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (905 aa)
AGC68866.1Hypothetical protein. (143 aa)
nifH1Nitrogenase iron protein NifH. (105 aa)
AGC68903.1Flavin reductase domain protein FMN-binding protein. (147 aa)
ddh2Meso-diaminopimelate D-dehydrogenase Ddh; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (294 aa)
cooS1Carbon monoxide dehydrogenase 1. (665 aa)
nifENitrogenase iron-molybdenum cofactor biosynthesis protein NifE; Belongs to the NifD/NifK/NifE/NifN family. (514 aa)
nifKNitrogenase NifK. (447 aa)
nifH2Nitrogenase iron protein NifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (282 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase 1; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
spoVFADipicolinate synthase A chain. (289 aa)
AGC69077.1Radical SAM domain protein. (452 aa)
folADihydrofolate reductase FolA. (166 aa)
ldhL-lactate dehydrogenase Ldh; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
cotJC1Spore coat protein CotJC. (72 aa)
cotJC2Spore coat protein CotJC. (120 aa)
AGC69122.1FAD-dependent pyridine nucleotide-disulfide oxidoreductase. (357 aa)
AGC69125.1FAD dependent oxidoreductase. (357 aa)
alkHNAD-dependent aldehyde dehydrogenase AlkH; Belongs to the aldehyde dehydrogenase family. (456 aa)
Adh6Iron-containing alcohol dehydrogenase. (393 aa)
AGC69208.1Acid phosphatase/vanadium-dependent haloperoxidase-like protein. (146 aa)
AGC69269.1Hypothetical protein. (234 aa)
AGC69276.1Putative NADH dehydrogenase/NAD(P)H nitroreductase. (167 aa)
tyrAPrephenate dehydrogenase TyrA. (367 aa)
AGC69316.1Oxidoreductase, short chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
AGC69346.1Hypothetical protein. (158 aa)
rnfBElectron transport complex protein RnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (265 aa)
rnfAElectron transport complex protein RnfA; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (193 aa)
rnfGElectron transport complex protein RnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. (190 aa)
rnfDElectron transport complex protein RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. (322 aa)
rnfCElectron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (438 aa)
NfhANi,Fe-hydrogenase III large subunit. (455 aa)
NfhBNi,Fe-hydrogenase III small subunit. (149 aa)
AGC69392.1Hypothetical protein. (206 aa)
AGC69398.1Thioredoxin-disulfide reductase. (422 aa)
AGC69399.1Glutaredoxin-like protein, YruB-family. (76 aa)
hisDHistidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
AGC69443.1Putative NADH dehydrogenase/NAD(P)H nitroreductase. (169 aa)
AGC69467.1Hypothetical protein. (612 aa)
AGC69472.1Rubredoxin-type Fe(Cys)4 protein. (111 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
trxB2Thioredoxin reductase TrxB. (292 aa)
AGC69503.1Hypothetical protein. (176 aa)
AGC69506.1Aldo/keto reductase. (330 aa)
AGC69544.1Rubredoxin. (73 aa)
AGC69551.1FAD-dependent pyridine nucleotide-disulfide oxidoreductase. (593 aa)
rbr1Rubrerythrin-1. (198 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
nadB1L-aspartate oxidase 1; Catalyzes the oxidation of L-aspartate to iminoaspartate. (529 aa)
MaeNAD-dependent malic enzyme. (390 aa)
mdhMalate dehydrogenase Mdh; Belongs to the LDH2/MDH2 oxidoreductase family. (368 aa)
AGC69672.1Hypothetical protein. (362 aa)
nrdZRibonucleoside-diphosphate reductase NrdZ; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (752 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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