STRINGSTRING
AGC68235.1 AGC68235.1 AGC67048.1 AGC67048.1 nrdG nrdG Ffh1 Ffh1 lipA lipA nifJ1 nifJ1 HydE HydE iorA iorA purF1 purF1 miaB1 miaB1 nuoF2 nuoF2 FhbC FhbC kamA1 kamA1 hcp hcp rimO rimO AGC68155.1 AGC68155.1 AGC68158.1 AGC68158.1 AGC68272.1 AGC68272.1 queH queH leuC leuC ispG ispG nifJ2 nifJ2 ispH ispH degS degS nadA nadA kamA2 kamA2 rbr rbr gltB gltB AGC68813.1 AGC68813.1 FhmB FhmB nifH1 nifH1 rumA rumA cooS1 cooS1 nifH2 nifH2 hemN hemN rlmN rlmN AGC69077.1 AGC69077.1 miaB2 miaB2 AGC69134.1 AGC69134.1 addB addB nth nth AGC69270.1 AGC69270.1 thiC thiC purF2 purF2 AGC69332.1 AGC69332.1 rnfB rnfB rnfC rnfC NfhB NfhB AGC69628.1 AGC69628.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGC68235.1Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunit; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa)
AGC67048.1Glutamate 5-kinase. (275 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (169 aa)
Ffh1Hydrogenase large subunit domain protein. (445 aa)
lipALipoyl synthase LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (288 aa)
nifJ1Pyruvate-flavodoxin oxidoreductase NifJ. (1177 aa)
HydERadical SAM domain-containing protein. (348 aa)
iorAIndolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (582 aa)
purF1Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (471 aa)
miaB1(dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (480 aa)
nuoF2NADH-quinone oxidoreductase subunit F 2. (597 aa)
FhbCFe only hydrogenase 1. (587 aa)
kamA1L-lysine 2,3-aminomutase KamA. (409 aa)
hcpHydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (520 aa)
rimORibosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (446 aa)
AGC68155.1Radical SAM domain protein. (338 aa)
AGC68158.1Putative fumarate hydratase subunit alpha. (281 aa)
AGC68272.1Hypothetical protein. (311 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (188 aa)
leuC3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (353 aa)
nifJ2Pyruvate-flavodoxin oxidoreductase NifJ. (1171 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (678 aa)
degSSensor protein DegS. (382 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa)
kamA2L-lysine 2,3-aminomutase KamA. (370 aa)
rbrRubrerythrin. (220 aa)
gltBGlutamate synthase GltB; Belongs to the glutamate synthase family. (501 aa)
AGC68813.1Hypothetical protein. (308 aa)
FhmBPutative PAS/PAC sensor protein. (556 aa)
nifH1Nitrogenase iron protein NifH. (105 aa)
rumA23S rRNA (uracil-5-)-methyltransferase RumA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (454 aa)
cooS1Carbon monoxide dehydrogenase 1. (665 aa)
nifH2Nitrogenase iron protein NifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (282 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase 1; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (348 aa)
AGC69077.1Radical SAM domain protein. (452 aa)
miaB22-methylthioadenine synthetase MiaB. (432 aa)
AGC69134.1Radical SAM domain protein. (325 aa)
addBATP-dependent helicase/deoxyribonuclease subunit B; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1158 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
AGC69270.1Hypothetical protein. (245 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa)
purF2Amidophosphoribosyltransferase PurF; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (466 aa)
AGC69332.1Phage SPO1 DNA polymerase-like protein. (190 aa)
rnfBElectron transport complex protein RnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (265 aa)
rnfCElectron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (438 aa)
NfhBNi,Fe-hydrogenase III small subunit. (149 aa)
AGC69628.1Sensor signal transduction histidine kinase. (582 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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