(36 nodes) Innate Immune System network (Thermoclostridium stercorarium)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:
	serS2	serine--tRNA ligase 2; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (431 aa)
	AGC67128.1	alpha-L-fucosidase. (490 aa)
	AGC67186.1	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family. (903 aa)
	lacZ1	Beta-galactosidase LacZ; Belongs to the glycosyl hydrolase 2 family. (800 aa)
	atpI1	V-type ATP synthase subunit I; Belongs to the V-ATPase 116 kDa subunit family. (657 aa)
	atpE1	V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (199 aa)
	flgL	Flagellar hook-associated protein 3. (303 aa)
	fla	Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (414 aa)
	pncB	Nicotinate phosphoribosyltransferase PncB; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (487 aa)
	AGC69429.1	Metallophosphoesterase. (379 aa)
	atpC3	V-type ATP synthase subunit C. (345 aa)
	atpI2	V-type ATP synthase subunit I; Belongs to the V-ATPase 116 kDa subunit family. (657 aa)
	atpF2	V-type ATP synthase subunit F. (102 aa)
	atpA2	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (597 aa)
	atpE2	V-type ATP synthase subunit E. (201 aa)
	atpB2	V-type ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (468 aa)
	atpD2	V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (205 aa)
	AGC69351.1	SCP-like extracellular protein. (260 aa)
	AGC69289.1	Hypothetical protein. (46 aa)
	AGC69031.1	Patatin. (342 aa)
	cdd	Cytidine deaminase Cdd; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (139 aa)
	AGC68842.1	Adenine/guanine phosphoribosyltransferase-like protein. (194 aa)
	xpt	Xanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa)
	AGC68403.1	Glycogen debranching enzyme. (654 aa)
	uidA	Beta-glucuronidase UidA; Belongs to the glycosyl hydrolase 2 family. (593 aa)
	AGC68176.1	Dockerin type 1. (603 aa)
	pgiB	Glucose-6-phosphate isomerase PgiB; Belongs to the GPI family. (450 aa)
	AGC68062.1	Putative trehalase / alfa-L-rhamnosidase / mannosyl oligosaccharide glucosidase. (432 aa)
	lacZ3	Beta-galactosidase LacZ; Belongs to the glycosyl hydrolase 2 family. (1146 aa)
	deoC	Deoxyribose-phosphate aldolase DeoC; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (235 aa)
	lacZ2	Beta-galactosidase LacZ. (1023 aa)
	atpD1	V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (225 aa)
	atpB	V-type ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (459 aa)
	atpA	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (590 aa)
	atpF1	V-type ATP synthase subunit F. (105 aa)
	atpC1	V-type ATP synthase subunit C. (335 aa)

Your Current Organism:

Thermoclostridium stercorarium

NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGC67128.1	AGC67186.1	Cst_c00970	Cst_c01600	alpha-L-fucosidase.	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	0.511
AGC67128.1	lacZ1	Cst_c00970	Cst_c02440	alpha-L-fucosidase.	Beta-galactosidase LacZ; Belongs to the glycosyl hydrolase 2 family.	0.647
AGC67128.1	lacZ3	Cst_c00970	Cst_c09830	alpha-L-fucosidase.	Beta-galactosidase LacZ; Belongs to the glycosyl hydrolase 2 family.	0.546
AGC67186.1	AGC67128.1	Cst_c01600	Cst_c00970	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	alpha-L-fucosidase.	0.511
AGC67186.1	AGC68062.1	Cst_c01600	Cst_c10640	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	Putative trehalase / alfa-L-rhamnosidase / mannosyl oligosaccharide glucosidase.	0.417
AGC67186.1	lacZ2	Cst_c01600	Cst_c06190	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	Beta-galactosidase LacZ.	0.483
AGC67186.1	lacZ3	Cst_c01600	Cst_c09830	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	Beta-galactosidase LacZ; Belongs to the glycosyl hydrolase 2 family.	0.559
AGC68062.1	AGC67186.1	Cst_c10640	Cst_c01600	Putative trehalase / alfa-L-rhamnosidase / mannosyl oligosaccharide glucosidase.	Glycoside hydrolase family 2; Belongs to the glycosyl hydrolase 2 family.	0.417
AGC68842.1	xpt	Cst_c18650	Cst_c15880	Adenine/guanine phosphoribosyltransferase-like protein.	Xanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.909
atpA	atpA2	Cst_c03480	Cst_c24530	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	0.903
atpA	atpB	Cst_c03480	Cst_c03490	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.	0.991
atpA	atpB2	Cst_c03480	Cst_c24520	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.	0.965
atpA	atpC1	Cst_c03480	Cst_c03460	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit C.	0.993
atpA	atpC3	Cst_c03480	Cst_c24580	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit C.	0.958
atpA	atpD1	Cst_c03480	Cst_c03500	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.998
atpA	atpD2	Cst_c03480	Cst_c24510	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.986
atpA	atpE1	Cst_c03480	Cst_c03450	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.987
atpA	atpE2	Cst_c03480	Cst_c24540	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit E.	0.953
atpA	atpF1	Cst_c03480	Cst_c03470	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit F.	0.993
atpA	atpF2	Cst_c03480	Cst_c24550	V-type ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.	V-type ATP synthase subunit F.	0.948

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