STRINGSTRING
nrdD nrdD cysD cysD nodQ nodQ cysC cysC purF1 purF1 AGC67832.1 AGC67832.1 AGC67898.1 AGC67898.1 guaB guaB purL purL purB purB AGC68333.1 AGC68333.1 AGC68368.1 AGC68368.1 relA relA prs prs guaA guaA pgcA pgcA nudF nudF xpt xpt purA purA AGC68842.1 AGC68842.1 gmk gmk purD purD purH purH purN purN purM purM purE purE punA punA AGC69237.1 AGC69237.1 pyk pyk AGC69293.1 AGC69293.1 purF2 purF2 deoB deoB purC purC prsA prsA adk adk hpt hpt nrdZ nrdZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nrdDAnaerobic ribonucleoside-triphosphate reductase NrdD. (823 aa)
cysDSulfate adenylyltransferase subunit 2. (293 aa)
nodQBifunctional enzyme NodQ; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (604 aa)
cysCAdenylyl-sulfate kinase CysC; Catalyzes the synthesis of activated sulfate. (199 aa)
purF1Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (471 aa)
AGC67832.1Adenylate cyclase. (156 aa)
AGC67898.1Hydrolase (HAD superfamily)-like protein. (181 aa)
guaBInosine-5'-monophosphate dehydrogenase GuaB. (497 aa)
purLPhosphoribosylformylglycinamidine synthase PurL. (1251 aa)
purBAdenylosuccinate lyase PurB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
AGC68333.1Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa)
AGC68368.1Deoxyguanosinetriphosphate triphosphohydrolase-like protein; Belongs to the dGTPase family. Type 2 subfamily. (334 aa)
relAGTP pyrophosphokinase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (759 aa)
prsRibose-phosphate pyrophosphokinase Prs. (318 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (513 aa)
pgcAPhosphoglucomutase PgcA. (575 aa)
nudFADP-ribose pyrophosphatase NudF; Belongs to the Nudix hydrolase family. (183 aa)
xptXanthine phosphoribosyltransferase Xpt; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa)
purAAdenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (421 aa)
AGC68842.1Adenine/guanine phosphoribosyltransferase-like protein. (194 aa)
gmkGuanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (190 aa)
purDPhosphoribosylamine--glycine ligase PurD; Belongs to the GARS family. (419 aa)
purHBifunctional purine biosynthesis protein PurH. (513 aa)
purNPhosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase PurM. (363 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa)
punAPurine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (275 aa)
AGC69237.1RelA/SpoT domain-containing protein. (222 aa)
pykPyruvate kinase Pyk; Belongs to the pyruvate kinase family. (587 aa)
AGC69293.1Hypothetical protein. (296 aa)
purF2Amidophosphoribosyltransferase PurF; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (466 aa)
deoBPhosphopentomutase DeoB; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (396 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (295 aa)
prsARibose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
adkAdenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
hptHypoxanthine-guanine phosphoribosyltransferase Hpt; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa)
nrdZRibonucleoside-diphosphate reductase NrdZ; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (752 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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