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mgsA1 mgsA1 dkgA dkgA fhs fhs cysQ cysQ cysD cysD nodQ nodQ cysC cysC cysE cysE glxK glxK glcK glcK hom hom hprA hprA mgsA2 mgsA2 Pgm1 Pgm1 serC serC NfnA NfnA apgM apgM gcdB gcdB OadG OadG rhaA rhaA pfp pfp nifJ1 nifJ1 bdhA bdhA leuC1 leuC1 icd icd glyA glyA paaK paaK yutF yutF kdgA kdgA Gck1 Gck1 mro mro acoC acoC lpdA lpdA rhaB rhaB AGC67944.1 AGC67944.1 dapF dapF fba fba gdhA gdhA pckG pckG AGC68032.1 AGC68032.1 TrkA1 TrkA1 TrkB1 TrkB1 AGC68087.1 AGC68087.1 AGC68096.1 AGC68096.1 pgiB pgiB prpC prpC serA serA AGC68158.1 AGC68158.1 dapB dapB dapA dapA asd asd oadB oadB zwf zwf speA1 speA1 AGC68237.1 AGC68237.1 AGC68239.1 AGC68239.1 vorB vorB vorA vorA korC korC pta pta ackA ackA lysC lysC prs prs thrC thrC nifJ2 nifJ2 pgcA pgcA folD folD pfkA pfkA araD araD glnA1 glnA1 glnA2 glnA2 nasD nasD adhE adhE glnA3 glnA3 cooS1 cooS1 cysK cysK nifE nifE nifK nifK nifH2 nifH2 lysA lysA ppdK ppdK rpe rpe gpmI gpmI tpiA tpiA pgk pgk gapA gapA ldh ldh pfkA2 pfkA2 eno eno gltX gltX alkH alkH TrkB2 TrkB2 TrkA2 TrkA2 glnA4 glnA4 fucA fucA pyk pyk gltA gltA AGC69401.1 AGC69401.1 argD argD prsA prsA gnd gnd kdgK kdgK RpiB RpiB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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mgsA1Methylglyoxal synthase MgsA; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (157 aa)
dkgA2,5-diketo-D-gluconic acid reductase A. (338 aa)
fhsFormate--tetrahydrofolate ligase Fhs; Belongs to the formate--tetrahydrofolate ligase family. (559 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase CysQ; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (260 aa)
cysDSulfate adenylyltransferase subunit 2. (293 aa)
nodQBifunctional enzyme NodQ; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (604 aa)
cysCAdenylyl-sulfate kinase CysC; Catalyzes the synthesis of activated sulfate. (199 aa)
cysESerine acetyltransferase CysE. (317 aa)
glxKGlycerate kinase GlxK; Belongs to the glycerate kinase type-1 family. (378 aa)
glcKGlucokinase GlcK. (320 aa)
homHomoserine dehydrogenase Hom. (423 aa)
hprAGlycerate dehydrogenase HprA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
mgsA2Methylglyoxal synthase MgsA. (134 aa)
Pgm1Phosphoglycerate mutase. (189 aa)
serCPhosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (362 aa)
NfnANADPH-dependent glutamate synthase. (465 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM. (401 aa)
gcdBglutaconyl-CoA decarboxylase subunit beta; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (395 aa)
OadGOxaloacetate decarboxylase, gamma chain. (121 aa)
rhaAL-rhamnose isomerase RhaA; Belongs to the rhamnose isomerase family. (425 aa)
pfpPyrophosphate--fructose 6-phosphate 1-phosphotransferase Pfp; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (416 aa)
nifJ1Pyruvate-flavodoxin oxidoreductase NifJ. (1177 aa)
bdhANADH-dependent butanol dehydrogenase A. (388 aa)
leuC13-isopropylmalate dehydratase large subunit 1. (661 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
glyAPyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
paaKPhenylacetate-coenzyme A ligase PaaK; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (435 aa)
yutFPutative hydrolase YutF; Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro; Belongs to the HAD-like hydrolase superfamily. NagD family. (270 aa)
kdgAKHG/KDPG aldolase KdgA. (214 aa)
Gck1PfkB domain protein. (366 aa)
mroAldose 1-epimerase Mro; Converts alpha-aldose to the beta-anomer. (343 aa)
acoCDihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system. (456 aa)
lpdADihydrolipoyl dehydrogenase LpdA. (456 aa)
rhaBRhamnulokinase RhaB. (497 aa)
AGC67944.1Xylose isomerase domain-containing protein. (276 aa)
dapFDiaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
fbaFructose-bisphosphate aldolase Fba. (313 aa)
gdhAGlutamate dehydrogenase GdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (422 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (603 aa)
AGC68032.1Oxidoreductase domain protein. (337 aa)
TrkA1Putative transketolase N-terminal section. (276 aa)
TrkB1Putative transketolase C-terminal section. (342 aa)
AGC68087.1RecJ-like phosphoesterase domain-containing protein. (314 aa)
AGC68096.1Biotin/lipoyl attachment domain-containing protein. (140 aa)
pgiBGlucose-6-phosphate isomerase PgiB; Belongs to the GPI family. (450 aa)
prpC2-methylcitrate synthase PrpC; Belongs to the citrate synthase family. (457 aa)
serAD-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa)
AGC68158.1Putative fumarate hydratase subunit alpha. (281 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa)
dapADihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa)
oadBOxaloacetate decarboxylase beta chain; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (420 aa)
zwfGlucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (510 aa)
speA1Arginine decarboxylase SpeA. (486 aa)
AGC68237.1Tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit. (183 aa)
AGC68239.1Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit; Chain I. (68 aa)
vorBKetoisovalerate oxidoreductase subunit VorB. (357 aa)
vorAKetoisovalerate oxidoreductase subunit VorA. (248 aa)
korC2-oxoglutarate synthase subunit KorC. (177 aa)
ptaPhosphate acetyltransferase Pta. (330 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
lysCAspartokinase LysC; Belongs to the aspartokinase family. (451 aa)
prsRibose-phosphate pyrophosphokinase Prs. (318 aa)
thrCThreonine synthase ThrC. (497 aa)
nifJ2Pyruvate-flavodoxin oxidoreductase NifJ. (1171 aa)
pgcAPhosphoglucomutase PgcA. (575 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
pfkA6-phosphofructokinase PfkA; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
araDL-ribulose-5-phosphate 4-epimerase AraD. (228 aa)
glnA1Glutamine synthetase GlnA. (314 aa)
glnA2Glutamine synthetase GlnA. (700 aa)
nasDNitrite reductase [NAD(P)H]. (408 aa)
adhEAldehyde-alcohol dehydrogenase AdhE; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (905 aa)
glnA3Glutamine synthetase GlnA. (701 aa)
cooS1Carbon monoxide dehydrogenase 1. (665 aa)
cysKO-acetylserine sulfhydrylase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
nifENitrogenase iron-molybdenum cofactor biosynthesis protein NifE; Belongs to the NifD/NifK/NifE/NifN family. (514 aa)
nifKNitrogenase NifK. (447 aa)
nifH2Nitrogenase iron protein NifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (282 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (435 aa)
ppdKPyruvate, phosphate dikinase PpdK; Belongs to the PEP-utilizing enzyme family. (879 aa)
rpeRibulose-phosphate 3-epimerase Rpe; Belongs to the ribulose-phosphate 3-epimerase family. (232 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase GpmI; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (546 aa)
tpiATriosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
pgkPhosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (400 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase A; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
ldhL-lactate dehydrogenase Ldh; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
pfkA26-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate, the first committing step of glycolysis. (363 aa)
enoEnolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (438 aa)
gltXglutamate--tRNA ligase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (492 aa)
alkHNAD-dependent aldehyde dehydrogenase AlkH; Belongs to the aldehyde dehydrogenase family. (456 aa)
TrkB2Transketolase, C-terminal subunit. (310 aa)
TrkA2Transketolase, N-terminal subunit. (285 aa)
glnA4Glutamine synthetase GlnA. (698 aa)
fucAL-fuculose phosphate aldolase FucA. (429 aa)
pykPyruvate kinase Pyk; Belongs to the pyruvate kinase family. (587 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (465 aa)
AGC69401.1Coenzyme F390 synthetase-like protein. (453 aa)
argDAcetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
prsARibose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
kdgK2-keto-3-deoxygluconate kinase KdgK. (357 aa)
RpiBSugar-phosphate isomerase, RpiB/LacA/LacB family. (149 aa)
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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