STRINGSTRING
CCO22069.1 CCO22069.1 korA korA korB korB korC korC gltA gltA CCO22413.1 CCO22413.1 gcdB gcdB CCO22415.1 CCO22415.1 CCO22416.1 CCO22416.1 nifJ nifJ pta pta ytsJ ytsJ CCO22466.1 CCO22466.1 CCO22467.1 CCO22467.1 frdB frdB frdA frdA CCO22470.1 CCO22470.1 acyP acyP CCO22837.1 CCO22837.1 Acsm3 Acsm3 CCO22852.1 CCO22852.1 yngI yngI CCO22854.1 CCO22854.1 CCO22855.1 CCO22855.1 CCO22856.1 CCO22856.1 acsA acsA CCO23022.1 CCO23022.1 vorB vorB CCO23024.1 CCO23024.1 CCO23025.1 CCO23025.1 gabD gabD ilvD ilvD acs acs CCO23393.1 CCO23393.1 pflD pflD CCO23395.1 CCO23395.1 CCO23396.1 CCO23396.1 CCO23397.1 CCO23397.1 CCO23570.1 CCO23570.1 CCO23725.1 CCO23725.1 CCO23849.1 CCO23849.1 acs-2 acs-2 icd icd CCO24123.1 CCO24123.1 leuA leuA leuC leuC leuD leuD leuB leuB CCO24206.1 CCO24206.1 sucD sucD CCO24477.1 CCO24477.1 CCO24525.1 CCO24525.1 CCO24613.1 CCO24613.1 ilvN ilvN ilvB ilvB ilvC ilvC ilvH ilvH ilvB-2 ilvB-2 ilvE ilvE ackA ackA pta-2 pta-2 nifJ-2 nifJ-2 ilvH-2 ilvH-2 CCO25118.1 CCO25118.1 glcB glcB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCO22069.14Fe-4S ferredoxin iron-sulfur binding domain protein. (108 aa)
korA2-oxoglutarate synthase subunit korA. (383 aa)
korB2-oxoglutarate synthase subunit korB. (278 aa)
korC2-oxoglutarate synthase subunit korC. (207 aa)
gltACitrate synthase 1; Belongs to the citrate synthase family. (429 aa)
CCO22413.1Homologs of previously reported genes of unknown function. (578 aa)
gcdBGlutaconyl-CoA decarboxylase subunit beta. (375 aa)
CCO22415.1Homologs of previously reported genes of unknown function. (93 aa)
CCO22416.1Biotin/lipoyl attachment domain-containing protein. (610 aa)
nifJPyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. (1174 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ytsJNADP-dependent malic enzyme (conversion of malate into pyruvate); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (439 aa)
CCO22466.1Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit. (184 aa)
CCO22467.1Putative fumarate hydratase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (279 aa)
frdBFumarate reductase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (245 aa)
frdAFumarate reductase flavoprotein subunit. (617 aa)
CCO22470.1Fumarate reductase respiratory complex transmembrane subunit. (215 aa)
acyPAcylphosphatase. (90 aa)
CCO22837.1Aconitate hydratase. (639 aa)
Acsm3Acyl-coenzyme A synthetase ACSM3, mitochondrial; Function of strongly homologous gene; putative enzyme. (548 aa)
CCO22852.1Transcriptional regulator, XRE family. (185 aa)
yngIAcyl-CoA synthetase yngI; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (548 aa)
CCO22854.1Transcriptional regulator, XRE family. (188 aa)
CCO22855.1Protein of unknown function; No homology to any previously reported sequences. (56 aa)
CCO22856.1TPR repeat-containing protein. (250 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (627 aa)
CCO23022.1Homologs of previously reported genes of unknown function. (79 aa)
vorBKetoisovalerate oxidoreductase subunit vorB. (355 aa)
CCO23024.1Thiamine pyrophosphate protein domain protein TPP-binding. (252 aa)
CCO23025.1Pyruvate ferredoxin/flavodoxin oxidoreductase. (180 aa)
gabDSuccinate-semialdehyde dehydrogenase [NADP+] 1. (454 aa)
ilvDDihydroxy-acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (555 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa)
CCO23393.1Glycyl-radical enzyme activating protein family. (324 aa)
pflDFormate acetyltransferase 2. (796 aa)
CCO23395.1Uncharacterized 15.0 kDa protein in dhaT-dhaS intergenic region. (134 aa)
CCO23396.1Homologs of previously reported genes of unknown function. (317 aa)
CCO23397.1Protein of unknown function; No homology to any previously reported sequences. (40 aa)
CCO23570.1CoA-binding domain protein. (712 aa)
CCO23725.1Pyruvate, water dikinase. (859 aa)
CCO23849.1CoA-binding domain protein. (702 aa)
acs-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa)
icdIsocitrate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (381 aa)
CCO24123.1Pyruvate, water dikinase. (815 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (350 aa)
CCO24206.1Aminotransferase class IV. (316 aa)
sucDCoA-binding domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (698 aa)
CCO24477.1Pyruvate phosphate dikinase PEP/pyruvate-binding. (1192 aa)
CCO24525.1Uncharacterized AIPM/Hcit synthase family transferase aq_356; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
CCO24613.1Fumarate reductase respiratory complex transmembrane subunit. (216 aa)
ilvNAcetolactate synthase I, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (88 aa)
ilvBAcetolactate synthase (acetohydroxy-acid synthase) (large subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (552 aa)
ilvCAcetohydroxy-acid isomeroreductase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
ilvHAcetolactate synthase (acetohydroxy-acid synthase) (small subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (160 aa)
ilvB-2Acetolactate synthase (acetohydroxy-acid synthase) (large subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (563 aa)
ilvEBranched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
ackAAcetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
pta-2Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (705 aa)
nifJ-2Pyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. (1174 aa)
ilvH-2Putative acetolactate synthase small subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (159 aa)
CCO25118.1Pyruvate phosphate dikinase PEP/pyruvate-binding. (649 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (722 aa)
Your Current Organism:
Desulfovibrio hydrothermalis
NCBI taxonomy Id: 1121451
Other names: D. hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis AM13, Desulfovibrio hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis DSM 14728, Desulfovibrio hydrothermalis DSM 14728 = AM13
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