(40 nodes) Pyruvate metabolism, and Citrate cycle (TCA cycle) network (Desulfovibrio hydrothermalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCO22069.1	4Fe-4S ferredoxin iron-sulfur binding domain protein. (108 aa)
	korA	2-oxoglutarate synthase subunit korA. (383 aa)
	korB	2-oxoglutarate synthase subunit korB. (278 aa)
	korC	2-oxoglutarate synthase subunit korC. (207 aa)
	gltA	Citrate synthase 1; Belongs to the citrate synthase family. (429 aa)
	CCO22413.1	Homologs of previously reported genes of unknown function. (578 aa)
	gcdB	Glutaconyl-CoA decarboxylase subunit beta. (375 aa)
	CCO22415.1	Homologs of previously reported genes of unknown function. (93 aa)
	CCO22416.1	Biotin/lipoyl attachment domain-containing protein. (610 aa)
	nifJ	Pyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. (1174 aa)
	pta	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
	ytsJ	NADP-dependent malic enzyme (conversion of malate into pyruvate); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (439 aa)
	CCO22466.1	Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit. (184 aa)
	CCO22467.1	Putative fumarate hydratase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (279 aa)
	frdB	Fumarate reductase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (245 aa)
	frdA	Fumarate reductase flavoprotein subunit. (617 aa)
	CCO22470.1	Fumarate reductase respiratory complex transmembrane subunit. (215 aa)
	acyP	Acylphosphatase. (90 aa)
	CCO22837.1	Aconitate hydratase. (639 aa)
	acsA	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (627 aa)
	CCO23022.1	Homologs of previously reported genes of unknown function. (79 aa)
	vorB	Ketoisovalerate oxidoreductase subunit vorB. (355 aa)
	CCO23024.1	Thiamine pyrophosphate protein domain protein TPP-binding. (252 aa)
	CCO23025.1	Pyruvate ferredoxin/flavodoxin oxidoreductase. (180 aa)
	gabD	Succinate-semialdehyde dehydrogenase [NADP+] 1. (454 aa)
	acs	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa)
	CCO23570.1	CoA-binding domain protein. (712 aa)
	CCO23725.1	Pyruvate, water dikinase. (859 aa)
	CCO23849.1	CoA-binding domain protein. (702 aa)
	acs-2	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa)
	icd	Isocitrate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (381 aa)
	CCO24123.1	Pyruvate, water dikinase. (815 aa)
	sucD	CoA-binding domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (698 aa)
	CCO24477.1	Pyruvate phosphate dikinase PEP/pyruvate-binding. (1192 aa)
	CCO24613.1	Fumarate reductase respiratory complex transmembrane subunit. (216 aa)
	ackA	Acetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
	pta-2	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (705 aa)
	nifJ-2	Pyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. (1174 aa)
	CCO25118.1	Pyruvate phosphate dikinase PEP/pyruvate-binding. (649 aa)
	glcB	Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (722 aa)

Your Current Organism:

Desulfovibrio hydrothermalis

NCBI taxonomy Id: 1121451
Other names: D. hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis AM13, Desulfovibrio hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis DSM 14728, Desulfovibrio hydrothermalis DSM 14728 = AM13

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCO22069.1	CCO23022.1	DESAM_10088	DESAM_20735	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Homologs of previously reported genes of unknown function.	0.910
CCO22069.1	CCO23024.1	DESAM_10088	DESAM_20737	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Thiamine pyrophosphate protein domain protein TPP-binding.	0.955
CCO22069.1	CCO23025.1	DESAM_10088	DESAM_20738	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Pyruvate ferredoxin/flavodoxin oxidoreductase.	0.948
CCO22069.1	frdA	DESAM_10088	DESAM_20178	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Fumarate reductase flavoprotein subunit.	0.515
CCO22069.1	gabD	DESAM_10088	DESAM_20741	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Succinate-semialdehyde dehydrogenase [NADP+] 1.	0.814
CCO22069.1	icd	DESAM_10088	DESAM_21680	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Isocitrate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.915
CCO22069.1	korA	DESAM_10088	DESAM_10089	4Fe-4S ferredoxin iron-sulfur binding domain protein.	2-oxoglutarate synthase subunit korA.	0.998
CCO22069.1	korB	DESAM_10088	DESAM_10090	4Fe-4S ferredoxin iron-sulfur binding domain protein.	2-oxoglutarate synthase subunit korB.	0.996
CCO22069.1	korC	DESAM_10088	DESAM_10091	4Fe-4S ferredoxin iron-sulfur binding domain protein.	2-oxoglutarate synthase subunit korC.	0.998
CCO22069.1	nifJ	DESAM_10088	DESAM_20169	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Pyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.	0.974
CCO22069.1	nifJ-2	DESAM_10088	DESAM_22670	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Pyruvate-flavodoxin oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.	0.974
CCO22069.1	sucD	DESAM_10088	DESAM_22202	4Fe-4S ferredoxin iron-sulfur binding domain protein.	CoA-binding domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.977
CCO22069.1	vorB	DESAM_10088	DESAM_20736	4Fe-4S ferredoxin iron-sulfur binding domain protein.	Ketoisovalerate oxidoreductase subunit vorB.	0.975
CCO22413.1	CCO22415.1	DESAM_20122	DESAM_20124	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.936
CCO22413.1	CCO22416.1	DESAM_20122	DESAM_20125	Homologs of previously reported genes of unknown function.	Biotin/lipoyl attachment domain-containing protein.	0.938
CCO22413.1	CCO23024.1	DESAM_20122	DESAM_20737	Homologs of previously reported genes of unknown function.	Thiamine pyrophosphate protein domain protein TPP-binding.	0.816
CCO22413.1	CCO23570.1	DESAM_20122	DESAM_21289	Homologs of previously reported genes of unknown function.	CoA-binding domain protein.	0.800
CCO22413.1	CCO23725.1	DESAM_20122	DESAM_21448	Homologs of previously reported genes of unknown function.	Pyruvate, water dikinase.	0.911
CCO22413.1	CCO23849.1	DESAM_20122	DESAM_21572	Homologs of previously reported genes of unknown function.	CoA-binding domain protein.	0.800
CCO22413.1	CCO24123.1	DESAM_20122	DESAM_21850	Homologs of previously reported genes of unknown function.	Pyruvate, water dikinase.	0.911

page 1 of 44

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About