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asd asd metF metF mtap mtap CCO24689.1 CCO24689.1 accC-2 accC-2 CCO24793.1 CCO24793.1 thiL thiL CCO24847.1 CCO24847.1 CCO24887.1 CCO24887.1 ackA ackA pta-2 pta-2 CCO25031.1 CCO25031.1 CCO25033.1 CCO25033.1 ptb ptb bioF bioF CCO25093.1 CCO25093.1 CCO22138.1 CCO22138.1 accC accC accD accD CCO22186.1 CCO22186.1 CCO22305.1 CCO22305.1 CCO22322.1 CCO22322.1 CCO22380.1 CCO22380.1 metE metE mqnB mqnB dxs dxs CCO22459.1 CCO22459.1 pta pta ggt ggt sat sat Acsm3 Acsm3 srpH srpH cysK cysK acsA acsA CCO23074.1 CCO23074.1 mtnN mtnN acs acs CCO23181.1 CCO23181.1 CCO23233.1 CCO23233.1 folD folD CCO23571.1 CCO23571.1 CCO23595.1 CCO23595.1 CCO23851.1 CCO23851.1 bioD bioD bioA bioA bioB bioB acs-2 acs-2 lipA lipA CCO23916.1 CCO23916.1 metK metK CCO23968.1 CCO23968.1 mtnA mtnA thiE thiE thiC thiC CCO24136.1 CCO24136.1 thiG thiG CCO24138.1 CCO24138.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa)
mtapS-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (249 aa)
CCO24689.1Phosphomethylpyrimidine kinase. (454 aa)
accC-2Pyruvate carboxylase; Function of strongly homologous gene; enzyme. (472 aa)
CCO24793.1Acetyl-CoA carboxylase. (752 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa)
CCO24847.1Homoserine dehydrogenase. (429 aa)
CCO24887.1Adenylylsulfate kinase and related kinase-like protein. (202 aa)
ackAAcetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
pta-2Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (705 aa)
CCO25031.1Radical SAM domain protein. (335 aa)
CCO25033.1Biotin and thiamin synthesis associated. (476 aa)
ptbPhosphate butyryltransferase. (326 aa)
bioFPutative 8-amino-7-oxononanoate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (391 aa)
CCO25093.1Methyltransferase type 11. (250 aa)
CCO22138.1Cysteine synthase. (764 aa)
accCPyruvate carboxylase; Function of strongly homologous gene; enzyme. (472 aa)
accDAcetyl-CoA carboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (750 aa)
CCO22186.1Purine or other phosphorylase family 1. (240 aa)
CCO22305.1Cysteine synthase. (341 aa)
CCO22322.1Homologs of previously reported genes of unknown function. (320 aa)
CCO22380.1Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (757 aa)
mqnBPurine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (232 aa)
dxs1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (638 aa)
CCO22459.1Phosphoadenosine phosphosulfate reductase. (286 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa)
ggtGamma-glutamyltransferase; Function of strongly homologous gene; enzyme. (556 aa)
satSulfate adenylyltransferase. (426 aa)
Acsm3Acyl-coenzyme A synthetase ACSM3, mitochondrial; Function of strongly homologous gene; putative enzyme. (548 aa)
srpHSerine acetyltransferase, plasmid. (295 aa)
cysKCysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (627 aa)
CCO23074.1Homologs of previously reported genes of unknown function. (390 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (241 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa)
CCO23181.1Homocysteine S-methyltransferase. (805 aa)
CCO23233.1Protein of unknown function; No homology to any previously reported sequences. (137 aa)
folDMethylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
CCO23571.1DRTGG domain protein. (354 aa)
CCO23595.1Phosphoribosylglycinamide synthetase. (410 aa)
CCO23851.1DRTGG domain protein. (355 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (242 aa)
bioA7,8-diaminopelargonic acid synthase, PLP-dependent; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (427 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (327 aa)
acs-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (661 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)
CCO23916.1Putative Iron-sulfur cluster-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (518 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa)
CCO23968.1Homologs of previously reported genes of unknown function. (65 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (347 aa)
thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa)
thiCPhosphomethylpyrimidine synthase. (421 aa)
CCO24136.1Thiazole biosynthesis protein ThiH. (369 aa)
thiGHydroxyethylthiazole phosphate synthetase (thiamine biosynthesis); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (258 aa)
CCO24138.1Thiamine biosynthesis protein ThiS. (66 aa)
Your Current Organism:
Desulfovibrio hydrothermalis
NCBI taxonomy Id: 1121451
Other names: D. hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis AM13, Desulfovibrio hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis DSM 14728, Desulfovibrio hydrothermalis DSM 14728 = AM13
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