(13 nodes) Class I glutamine amidotransferase-like network (Desulfovibrio hydrothermalis)

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Your Input:
	guaA	GMP synthetase; Catalyzes the synthesis of GMP from XMP. (515 aa)
	cbiA	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (464 aa)
	cobB	Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (460 aa)
	CCO22768.1	Homologs of previously reported genes of unknown function. (414 aa)
	CCO22935.1	Intracellular protease, PfpI family. (187 aa)
	cobDQ	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (880 aa)
	pabA	4-amino-4-deoxychorismate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (190 aa)
	carA	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (374 aa)
	trpG	Anthranilate synthase component II. (184 aa)
	purQ	Phosphoribosylformylglycinamidine synthase 1. (269 aa)
	pyrG	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
	hisH	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa)
	CCO25455.1	Transcriptional regulator, AraC family. (329 aa)

Your Current Organism:

Desulfovibrio hydrothermalis

NCBI taxonomy Id: 1121451
Other names: D. hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis AM13, Desulfovibrio hydrothermalis AM13 = DSM 14728, Desulfovibrio hydrothermalis DSM 14728, Desulfovibrio hydrothermalis DSM 14728 = AM13

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCO22935.1	guaA	DESAM_20648	DESAM_10115	Intracellular protease, PfpI family.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.540
carA	guaA	DESAM_21655	DESAM_10115	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.571
carA	purQ	DESAM_21655	DESAM_21967	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	Phosphoribosylformylglycinamidine synthase 1.	0.975
carA	pyrG	DESAM_21655	DESAM_21968	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.400
cbiA	cobB	DESAM_20114	DESAM_20464	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.913
cbiA	cobDQ	DESAM_20114	DESAM_21023	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.959
cobB	cbiA	DESAM_20464	DESAM_20114	Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.913
cobB	cobDQ	DESAM_20464	DESAM_21023	Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.965
cobDQ	cbiA	DESAM_21023	DESAM_20114	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.959
cobDQ	cobB	DESAM_21023	DESAM_20464	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.965
cobDQ	guaA	DESAM_21023	DESAM_10115	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.507
cobDQ	hisH	DESAM_21023	DESAM_22638	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.825
guaA	CCO22935.1	DESAM_10115	DESAM_20648	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Intracellular protease, PfpI family.	0.540
guaA	carA	DESAM_10115	DESAM_21655	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	0.571
guaA	cobDQ	DESAM_10115	DESAM_21023	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.507
guaA	hisH	DESAM_10115	DESAM_22638	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.556
guaA	purQ	DESAM_10115	DESAM_21967	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylformylglycinamidine synthase 1.	0.833
guaA	pyrG	DESAM_10115	DESAM_21968	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.971
hisH	cobDQ	DESAM_22638	DESAM_21023	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.825
hisH	guaA	DESAM_22638	DESAM_10115	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.556

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