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dut dut SHK01383.1 SHK01383.1 gmk gmk pyrH pyrH guaB guaB SHK36641.1 SHK36641.1 SHK36678.1 SHK36678.1 surE surE SHK49671.1 SHK49671.1 SHK59916.1 SHK59916.1 SHK59964.1 SHK59964.1 guaA guaA SHK77191.1 SHK77191.1 SHK80743.1 SHK80743.1 SHK81589.1 SHK81589.1 SHK89258.1 SHK89258.1 pyrG pyrG purA purA SHL04441.1 SHL04441.1 SHL09346.1 SHL09346.1 ndk ndk tdk tdk purH purH SHL23162.1 SHL23162.1 pyrD pyrD purE purE carA carA SHL50569.1 SHL50569.1 SHL51090.1 SHL51090.1 SHL54586.1 SHL54586.1 adk adk SHL60012.1 SHL60012.1 purF purF purN purN SHL60204.1 SHL60204.1 purC purC SHL60338.1 SHL60338.1 purL purL pyrE pyrE SHL60478.1 SHL60478.1 SHL60522.1 SHL60522.1 SHL66184.1 SHL66184.1 SHL66274.1 SHL66274.1 SHL74161.1 SHL74161.1 thyA thyA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
SHK01383.1XTP/dITP diphosphohydrolase. (279 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (194 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
SHK36641.1Uridine kinase; Belongs to the uridine kinase family. (211 aa)
SHK36678.1XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
surE5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (291 aa)
SHK49671.1Cytidine deaminase. (163 aa)
SHK59916.15'-nucleotidase, C-terminal domain. (253 aa)
SHK59964.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (308 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (510 aa)
SHK77191.1dCTP deaminase. (178 aa)
SHK80743.1Uridine phosphorylase. (290 aa)
SHK81589.1AMP nucleosidase. (257 aa)
SHK89258.1Dihydroorotate dehydrogenase. (250 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (583 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
SHL04441.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
SHL09346.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
tdkThymidine kinase. (182 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (511 aa)
SHL23162.1Uracil phosphoribosyltransferase. (230 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (186 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (359 aa)
SHL50569.1Carbamoyl-phosphate synthase large subunit. (1086 aa)
SHL51090.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
SHL54586.1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa)
SHL60012.1Phosphoribosylformylglycinamidine cyclo-ligase. (367 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (502 aa)
purNPhosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
SHL60204.1Phosphoribosylamine--glycine ligase. (408 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (466 aa)
SHL60338.1Phosphoribosylformylglycinamidine synthase. (347 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (1009 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (204 aa)
SHL60478.1Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Belongs to the OMP decarboxylase family. Type 2 subfamily. (253 aa)
SHL60522.1Dihydroorotate dehydrogenase (NAD+) catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (285 aa)
SHL66184.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa)
SHL66274.1Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa)
SHL74161.1Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (433 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
Your Current Organism:
Hymenobacter psychrotolerans
NCBI taxonomy Id: 1121959
Other names: H. psychrotolerans DSM 18569, Hymenobacter psychrotolerans DSM 18569, Hymenobacter psychrotolerans Tibet-IIU11, Hymenobacter sp. Tibet-IIU11
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