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| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (647 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (431 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa) |
| | SHK00071.1 | RNA polymerase, sigma subunit, ECF family; Belongs to the sigma-70 factor family. ECF subfamily. (211 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (347 aa) |
| | nadK | NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (297 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (237 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (296 aa) |
| | atpA | F-type H+-transporting ATPase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (527 aa) |
| | atpH | F-type H+-transporting ATPase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (186 aa) |
| | atpF | ATP synthase F0 subcomplex B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (85 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (354 aa) |
| | SHK04970.1 | uroporphyrinogen-III synthase. (276 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (962 aa) |
| | SHK06759.1 | SnoaL-like domain-containing protein. (156 aa) |
| | SHK08338.1 | Protein of unknown function. (746 aa) |
| | SHK08490.1 | RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa) |
| | queA | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (350 aa) |
| | SHK10276.1 | RNA polymerase, sigma 54 subunit, RpoN/SigL. (529 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (461 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa) |
| | SHK11888.1 | UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase. (197 aa) |
| | SHK11961.1 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (345 aa) |
| | SHK12536.1 | Predicted secreted hydrolase. (375 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (423 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | SHK13165.1 | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (394 aa) |
| | SHK14816.1 | rfaE bifunctional protein, domain II; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (159 aa) |
| | coaX | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa) |
| | SHK18918.1 | Radical SAM additional 4Fe4S-binding SPASM domain-containing protein. (340 aa) |
| | SHK19288.1 | 4a-hydroxytetrahydrobiopterin dehydratase. (85 aa) |
| | SHK19680.1 | Hypothetical protein. (183 aa) |
| | SHK27449.1 | RNA polymerase sigma-70 factor, ECF subfamily. (217 aa) |
| | SHK29022.1 | RNA polymerase, sigma subunit, ECF family; Belongs to the sigma-70 factor family. ECF subfamily. (215 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (194 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (196 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (188 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1300 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1450 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | SHK32454.1 | RNA polymerase sigma-70 factor, ECF subfamily. (188 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | SHK35116.1 | FRG domain-containing protein. (279 aa) |
| | SHK35356.1 | Nicotinamide-nucleotide adenylyltransferase, NadR type. (177 aa) |
| | SHK35459.1 | Predicted N-acyltransferase, GNAT family. (138 aa) |
| | queG | Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (310 aa) |
| | SHK36641.1 | Uridine kinase; Belongs to the uridine kinase family. (211 aa) |
| | SHK36795.1 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (411 aa) |
| | SHK36833.1 | DNA polymerase-3 subunit delta'. (379 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (315 aa) |
| | SHK37009.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (301 aa) |
| | accD | acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa) |
| | SHK39374.1 | Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family. (327 aa) |
| | SHK39863.1 | DNA polymerase III, alpha subunit. (1228 aa) |
| | queE | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa) |
| | SHK45883.1 | Uncharacterized conserved protein GlcG, DUF336 family. (135 aa) |
| | SHK46067.1 | Predicted ATPase. (406 aa) |
| | ribBA | GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (417 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (695 aa) |
| | SHK48770.1 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (641 aa) |
| | SHK48804.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (723 aa) |
| | SHK50411.1 | Magnesium chelatase subunit I. (519 aa) |
| | SHK50778.1 | Nicotinamide-nucleotide adenylyltransferase, NadR type. (353 aa) |
| | SHK51599.1 | Radical SAM/Cys-rich domain-containing protein. (349 aa) |
| | SHK51729.1 | RNA polymerase sigma-70 factor, ECF subfamily. (179 aa) |
| | SHK52338.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) |
| | SHK52468.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (350 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa) |
| | SHK57209.1 | DNA polymerase (family 10). (584 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (716 aa) |
| | folE | GTP cyclohydrolase I. (223 aa) |
| | SHK58011.1 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (135 aa) |
| | SHK58946.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | SHK61143.1 | cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (182 aa) |
| | comB | 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (240 aa) |
| | queA-2 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (412 aa) |
| | priA | Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (849 aa) |
| | SHK63065.1 | Cytochrome c oxidase assembly protein subunit 15. (365 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (287 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | SHK67025.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (697 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa) |
| | guaA | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (440 aa) |
| | SHK77191.1 | dCTP deaminase. (178 aa) |
| | SHK77310.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (200 aa) |
| | SHK78833.1 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | SHK79915.1 | Competence/damage-inducible protein cinA; Belongs to the CinA family. (422 aa) |
| | SHK85587.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. (160 aa) |
| | SHK85916.1 | Nicotinamide riboside kinase. (183 aa) |
| | SHK87854.1 | Putative hydrolase of the HAD superfamily. (224 aa) |
| | SHK88437.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (189 aa) |
| | SHK88593.1 | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (455 aa) |
| | SHK88730.1 | Parallel beta-helix repeat (two copies). (764 aa) |
| | SHK89258.1 | Dihydroorotate dehydrogenase. (250 aa) |
| | SHK89792.1 | Protein of unknown function. (76 aa) |
| | SHK90090.1 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (443 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (206 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa) |
| | SHK94144.1 | Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (317 aa) |
| | SHK95028.1 | ApaG protein. (128 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (583 aa) |
| | SHK98426.1 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (138 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | SHL01243.1 | RNA polymerase sigma-70 factor, ECF subfamily. (183 aa) |
| | SHL01655.1 | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase. (256 aa) |
| | SHL02477.1 | AAA domain-containing protein, putative AbiEii toxin, Type IV TA system. (375 aa) |
| | SHL02515.1 | Hypothetical protein. (245 aa) |
| | SHL03310.1 | Hypothetical protein. (122 aa) |
| | SHL03515.1 | Hypothetical protein; Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family. (502 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (343 aa) |
| | SHL04095.1 | Adenylate cyclase, class 3. (315 aa) |
| | SHL04441.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | SHL06668.1 | Ca-activated chloride channel family protein. (349 aa) |
| | SHL09346.1 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | SHL09491.1 | Oxygen-dependent protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (443 aa) |
| | SHL10344.1 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (248 aa) |
| | SHL10802.1 | ElaA protein. (149 aa) |
| | SHL12784.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (591 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (154 aa) |
| | SHL17668.1 | Coproporphyrinogen oxidase. (313 aa) |
| | SHL18533.1 | Phosphomevalonate kinase. (182 aa) |
| | SHL19030.1 | RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | SHL19335.1 | Hypothetical protein. (263 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | tdk | Thymidine kinase. (182 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (511 aa) |
| | SHL23162.1 | Uracil phosphoribosyltransferase. (230 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa) |
| | SHL25183.1 | Predicted N-acyltransferase, GNAT family. (149 aa) |
| | SHL27028.1 | Hypothetical protein. (1025 aa) |
| | SHL27549.1 | RNA polymerase sigma-70 factor, ECF subfamily. (186 aa) |
| | SHL33429.1 | Initiator Replication protein. (313 aa) |
| | SHL34085.1 | Predicted ATP-binding protein involved in virulence. (451 aa) |
| | SHL39776.1 | Porphobilinogen synthase; Belongs to the ALAD family. (330 aa) |
| | SHL39873.1 | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | SHL40235.1 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (197 aa) |
| | dacA | TIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (281 aa) |
| | SHL41011.1 | Dihydropteroate synthase. (293 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (301 aa) |
| | SHL47097.1 | Nicotinamide-nucleotide amidase; Belongs to the CinA family. (175 aa) |
| | SHL47387.1 | Deoxyadenosine/deoxycytidine kinase. (207 aa) |
| | SHL49272.1 | rfaE bifunctional protein, domain I. (338 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (344 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (186 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (359 aa) |
| | dinB | DNA polymerase-4; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (359 aa) |
| | SHL53632.1 | UDPglucose 6-dehydrogenase. (445 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (302 aa) |
| | SHL54292.1 | WbqC-like protein family protein. (235 aa) |
| | SHL54586.1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (207 aa) |
| | SHL54756.1 | RNA polymerase sigma-70 factor, ECF subfamily. (168 aa) |
| | SHL55472.1 | RNA polymerase Rpb6. (117 aa) |
| | SHL55513.1 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (183 aa) |
| | SHL55548.1 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (216 aa) |
| | SHL56875.1 | WbqC-like protein family protein. (211 aa) |
| | SHL58460.1 | Cell surface protein SprA. (2484 aa) |
| | SHL59037.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (180 aa) |
| | SHL59638.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (495 aa) |
| | SHL60012.1 | Phosphoribosylformylglycinamidine cyclo-ligase. (367 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (502 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | SHL60204.1 | Phosphoribosylamine--glycine ligase. (408 aa) |
| | SHL60252.1 | SnoaL-like domain-containing protein. (128 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (466 aa) |
| | SHL60338.1 | Phosphoribosylformylglycinamidine synthase. (347 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (1009 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (204 aa) |
| | SHL60478.1 | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Belongs to the OMP decarboxylase family. Type 2 subfamily. (253 aa) |
| | SHL60522.1 | Dihydroorotate dehydrogenase (NAD+) catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (285 aa) |
| | SHL63108.1 | RNA polymerase sigma-70 factor, ECF subfamily. (216 aa) |
| | SHL64021.1 | Protoporphyrinogen oxidase. (404 aa) |
| | SHL64552.1 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (295 aa) |
| | SHL66184.1 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa) |
| | SHL66274.1 | Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa) |
| | SHL66544.1 | Oxygen-independent coproporphyrinogen-3 oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (380 aa) |
| | SHL67112.1 | Molybdopterin molybdotransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (405 aa) |
| | moaC | Cyclic pyranopterin phosphate synthase; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (162 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (393 aa) |
| | SHL67224.1 | Molybdopterin synthase catalytic subunit. (139 aa) |
| | SHL67270.1 | Molybdopterin synthase sulfur carrier subunit. (80 aa) |
| | moaA | Cyclic pyranopterin phosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (335 aa) |
| | fdhD | FdhD protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (296 aa) |
| | nadE | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (644 aa) |
| | SHL70207.1 | RNA polymerase sigma-70 factor, ECF subfamily. (205 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (376 aa) |
| | SHL70614.1 | ATP synthase F1 subcomplex epsilon subunit. (79 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (501 aa) |
| | SHL70707.1 | Ribose-phosphate pyrophosphokinase. (309 aa) |
| | SHL70745.1 | Hypothetical protein. (213 aa) |
| | SHL73004.1 | RNA polymerase primary sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (287 aa) |
| | SHL73653.1 | Glycine C-acetyltransferase. (416 aa) |
| | SHL73776.1 | DNA polymerase III, delta subunit. (358 aa) |
| | SHL74161.1 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (433 aa) |
| | SHL74270.1 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (209 aa) |
| | SHL78731.1 | RNA polymerase sigma-70 factor, ECF subfamily. (182 aa) |
| | dnaX | DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (731 aa) |
| | SHL85157.1 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa) |
| | SHL88869.1 | Hypothetical protein. (228 aa) |
| | SHL90914.1 | Hypothetical protein. (98 aa) |
| | SHL91603.1 | Toprim-like. (867 aa) |
| | SHL93834.1 | RNA polymerase sigma-70 factor, ECF subfamily. (211 aa) |
| | SHL94712.1 | Predicted N-acyltransferase, GNAT family. (144 aa) |
| | SHL94888.1 | RNA polymerase sigma-70 factor, ECF subfamily. (171 aa) |
| | SHL96173.1 | Initiator Replication protein. (309 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | SHM01015.1 | Mg-chelatase subunit ChlD. (371 aa) |
| | SHM02538.1 | RNA polymerase sigma-70 factor, ECF subfamily. (196 aa) |
| | SHM05005.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (882 aa) |
| | SHM05443.1 | Ca-activated chloride channel family protein. (468 aa) |
| | SHM08129.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (284 aa) |
| | SHM10069.1 | Toprim-like. (758 aa) |
| | SHM12368.1 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (234 aa) |
| | SHM14216.1 | DNA polymerase-3 subunit epsilon. (504 aa) |
| | SHM15147.1 | Riboflavin synthase alpha chain. (196 aa) |
| | SHM15314.1 | Coproporphyrinogen oxidase. (318 aa) |
| | SHM15660.1 | RNA polymerase sigma-70 factor, ECF subfamily. (193 aa) |
| | cmk | Cytidylate kinase. (240 aa) |
| | SHM28167.1 | Hypothetical protein. (214 aa) |
| | SHM28678.1 | Initiator Replication protein. (375 aa) |
| | SHM29968.1 | Initiator Replication protein. (324 aa) |
| | SHM31928.1 | Initiator Replication protein. (315 aa) |
