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| | pepA_1 | Glutamyl aminopeptidase. (397 aa) |
| | cphA | Cyanophycin synthetase. (604 aa) |
| | asnO | Asparagine synthetase [glutamine-hydrolyzing] 3. (624 aa) |
| | yusO | Putative HTH-type transcriptional regulator YusO. (160 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (229 aa) |
| | hisS_1 | Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (379 aa) |
| | argE_1 | Acetylornithine deacetylase. (385 aa) |
| | argE_2 | Acetylornithine deacetylase. (365 aa) |
| | hrp1_1 | Hypoxic response protein 1. (136 aa) |
| | AQZ49619.1 | F1/F0 ATPase, Methanosarcina type, subunit 2. (97 aa) |
| | AQZ49620.1 | Putative F0F1-ATPase subunit. (98 aa) |
| | lvr_1 | Levodione reductase. (255 aa) |
| | arcC1 | Carbamate kinase 1; Belongs to the carbamate kinase family. (304 aa) |
| | argF_1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | arcA_1 | Arginine deiminase. (409 aa) |
| | AQZ49627.1 | C4-dicarboxylate anaerobic carrier. (482 aa) |
| | dadA | D-amino acid dehydrogenase small subunit. (419 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (218 aa) |
| | trpB_1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA_1 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | aroE_1 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | dat | D-alanine aminotransferase. (285 aa) |
| | arcA_2 | Arginase; Belongs to the arginase family. (307 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (107 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | pabB | Para-aminobenzoate synthase component 1. (382 aa) |
| | dapB_1 | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (416 aa) |
| | ldc | Lysine/ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (377 aa) |
| | pheA | P-protein. (291 aa) |
| | iaaA | Isoaspartyl peptidase precursor. (307 aa) |
| | AQZ51067.1 | Aspartate aminotransferase. (402 aa) |
| | AQZ51149.1 | Aspartate aminotransferase. (411 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (294 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (375 aa) |
| | aroK | Shikimate kinase 1; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (227 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (415 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | argH1_1 | Argininosuccinate lyase 1. (465 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | tyrC | Arogenate dehydrogenase. (307 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | aroQ_1 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase. (473 aa) |
| | aroQ_2 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | serB | Phosphoserine phosphatase. (295 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa) |
| | ilvA_1 | L-threonine dehydratase biosynthetic IlvA. (317 aa) |
| | dapA_3 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | nadX | L-aspartate dehydrogenase. (255 aa) |
| | argH1_2 | Argininosuccinate lyase 1. (504 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (308 aa) |
| | ilvA_2 | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | AQZ52728.1 | Aspartate aminotransferase. (400 aa) |
| | tdcG | L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (390 aa) |
| | ansA | Putative L-asparaginase. (337 aa) |
| | trpE | Anthranilate synthase component 1. (733 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (411 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (149 aa) |
| | trpA_2 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (277 aa) |
| | trpB_2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA_3 | Tryptophan synthase alpha chain. (259 aa) |
| | dapA_4 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (282 aa) |
| | tyrA | T-protein. (103 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa) |
| | aspC_2 | Aspartate aminotransferase. (388 aa) |
| | argF_2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | yjiE | Quorum-sensing regulator protein D; Belongs to the LysR transcriptional regulatory family. (307 aa) |
| | cuyA | L-cysteate sulfo-lyase. (341 aa) |
| | wbpE | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (400 aa) |
| | AQZ53601.1 | Aspartate racemase. (231 aa) |
| | hpsN_1 | Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | ydjP | AB hydrolase superfamily protein YdjP. (264 aa) |
