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pepA_1 pepA_1 cphA cphA asnO asnO yusO yusO hisG hisG hisS_1 hisS_1 dadA dadA trpF trpF trpB_1 trpB_1 trpA_1 trpA_1 aroE_1 aroE_1 dat dat hisE hisE hisF hisF hisA hisA hisH1 hisH1 hisB hisB pabB pabB pheA pheA iaaA iaaA AQZ51067.1 AQZ51067.1 AQZ51149.1 AQZ51149.1 aroB aroB aroK aroK aroA aroA hisD hisD tyrC tyrC hisC2 hisC2 aroQ_1 aroQ_1 aroH aroH aroQ_2 aroQ_2 serB serB trpC trpC trpD trpD ilvA_1 ilvA_1 nadX nadX ilvA_2 ilvA_2 aroC aroC AQZ52728.1 AQZ52728.1 tdcG tdcG hisC hisC ansA ansA trpE trpE hisI hisI trpA_2 trpA_2 trpB_2 trpB_2 trpA_3 trpA_3 tyrA tyrA yjiE yjiE cuyA cuyA wbpE wbpE AQZ53601.1 AQZ53601.1 hpsN_1 hpsN_1 ydjP ydjP
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pepA_1Glutamyl aminopeptidase. (397 aa)
cphACyanophycin synthetase. (604 aa)
asnOAsparagine synthetase [glutamine-hydrolyzing] 3. (624 aa)
yusOPutative HTH-type transcriptional regulator YusO. (160 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (229 aa)
hisS_1Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (379 aa)
dadAD-amino acid dehydrogenase small subunit. (419 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (218 aa)
trpB_1Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpA_1Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa)
aroE_1Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
datD-alanine aminotransferase. (285 aa)
hisEPhosphoribosyl-ATP pyrophosphatase. (107 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa)
hisH1Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisBImidazoleglycerol-phosphate dehydratase. (202 aa)
pabBPara-aminobenzoate synthase component 1. (382 aa)
pheAP-protein. (291 aa)
iaaAIsoaspartyl peptidase precursor. (307 aa)
AQZ51067.1Aspartate aminotransferase. (402 aa)
AQZ51149.1Aspartate aminotransferase. (411 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (375 aa)
aroKShikimate kinase 1; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (227 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (415 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
tyrCArogenate dehydrogenase. (307 aa)
hisC2Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa)
aroQ_13-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa)
aroHPhospho-2-dehydro-3-deoxyheptonate aldolase. (473 aa)
aroQ_23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
serBPhosphoserine phosphatase. (295 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
ilvA_1L-threonine dehydratase biosynthetic IlvA. (317 aa)
nadXL-aspartate dehydrogenase. (255 aa)
ilvA_2L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
AQZ52728.1Aspartate aminotransferase. (400 aa)
tdcGL-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa)
hisCHistidinol-phosphate aminotransferase. (390 aa)
ansAPutative L-asparaginase. (337 aa)
trpEAnthranilate synthase component 1. (733 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (149 aa)
trpA_2Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (277 aa)
trpB_2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa)
trpA_3Tryptophan synthase alpha chain. (259 aa)
tyrAT-protein. (103 aa)
yjiEQuorum-sensing regulator protein D; Belongs to the LysR transcriptional regulatory family. (307 aa)
cuyAL-cysteate sulfo-lyase. (341 aa)
wbpEUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (400 aa)
AQZ53601.1Aspartate racemase. (231 aa)
hpsN_1Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
ydjPAB hydrolase superfamily protein YdjP. (264 aa)
Your Current Organism:
Martelella mediterranea
NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316
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