(6 nodes) Methionine metabolic process network (Martelella mediterranea)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	xecA1	2-hydroxypropyl-CoM lyase. (342 aa)
	mdeA	Methionine gamma-lyase. (427 aa)
	metF	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (304 aa)
	metH	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1256 aa)
	metK	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family. (412 aa)
	metA	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (314 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
mdeA	metA	Mame_03050	Mame_04104	Methionine gamma-lyase.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.985
mdeA	metH	Mame_03050	Mame_03317	Methionine gamma-lyase.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.950
mdeA	xecA1	Mame_03050	Mame_00048	Methionine gamma-lyase.	2-hydroxypropyl-CoM lyase.	0.937
metA	mdeA	Mame_04104	Mame_03050	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	Methionine gamma-lyase.	0.985
metA	metF	Mame_04104	Mame_03276	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.891
metA	metH	Mame_04104	Mame_03317	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.823
metA	metK	Mame_04104	Mame_03899	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	0.636
metA	xecA1	Mame_04104	Mame_00048	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	2-hydroxypropyl-CoM lyase.	0.564
metF	metA	Mame_03276	Mame_04104	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.891
metF	metH	Mame_03276	Mame_03317	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.996
metF	metK	Mame_03276	Mame_03899	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	0.777
metF	xecA1	Mame_03276	Mame_00048	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	2-hydroxypropyl-CoM lyase.	0.949
metH	mdeA	Mame_03317	Mame_03050	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Methionine gamma-lyase.	0.950
metH	metA	Mame_03317	Mame_04104	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.823
metH	metF	Mame_03317	Mame_03276	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.996
metH	metK	Mame_03317	Mame_03899	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	0.950
metH	xecA1	Mame_03317	Mame_00048	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	2-hydroxypropyl-CoM lyase.	0.980
metK	metA	Mame_03899	Mame_04104	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.636
metK	metF	Mame_03899	Mame_03276	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.777
metK	metH	Mame_03899	Mame_03317	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.950