(19 nodes) Valine, leucine and isoleucine biosynthesis, and Lactate oxidation network (Martelella mediterranea)

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Your Input:
	cfiB	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1153 aa)
	pckA	Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa)
	lldD	L-lactate dehydrogenase. (382 aa)
	mdlB	(S)-mandelate dehydrogenase. (396 aa)
	ilvX	Putative acetolactate synthase large subunit IlvX. (519 aa)
	leuD	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (371 aa)
	ilvE	Branched-chain-amino-acid aminotransferase. (292 aa)
	AQZ51826.1	Putative FAD-linked oxidoreductase. (467 aa)
	leuA_1	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (539 aa)
	ilvI	Acetolactate synthase isozyme 3 large subunit. (590 aa)
	ilvH	Acetolactate synthase isozyme 3 small subunit. (190 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
	ppdK	Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (891 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa)
	leuA_2	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (566 aa)
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
	poxB	Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (570 aa)
	ldhA	D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQZ51826.1	cfiB	Mame_02499	Mame_00700	Putative FAD-linked oxidoreductase.	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.916
AQZ51826.1	ilvH	Mame_02499	Mame_02727	Putative FAD-linked oxidoreductase.	Acetolactate synthase isozyme 3 small subunit.	0.801
AQZ51826.1	ilvI	Mame_02499	Mame_02726	Putative FAD-linked oxidoreductase.	Acetolactate synthase isozyme 3 large subunit.	0.816
AQZ51826.1	ilvX	Mame_02499	Mame_01704	Putative FAD-linked oxidoreductase.	Putative acetolactate synthase large subunit IlvX.	0.816
AQZ51826.1	ldhA	Mame_02499	Mame_04349	Putative FAD-linked oxidoreductase.	D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.912
AQZ51826.1	leuA_1	Mame_02499	Mame_02646	Putative FAD-linked oxidoreductase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.800
AQZ51826.1	leuA_2	Mame_02499	Mame_04080	Putative FAD-linked oxidoreductase.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.800
AQZ51826.1	leuC	Mame_02499	Mame_04214	Putative FAD-linked oxidoreductase.	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.800
AQZ51826.1	leuD	Mame_02499	Mame_02081	Putative FAD-linked oxidoreductase.	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.800
AQZ51826.1	lldD	Mame_02499	Mame_01119	Putative FAD-linked oxidoreductase.	L-lactate dehydrogenase.	0.949
AQZ51826.1	mdlB	Mame_02499	Mame_01557	Putative FAD-linked oxidoreductase.	(S)-mandelate dehydrogenase.	0.950
AQZ51826.1	poxB	Mame_02499	Mame_04348	Putative FAD-linked oxidoreductase.	Pyruvate dehydrogenase; Belongs to the TPP enzyme family.	0.908
AQZ51826.1	ppdK	Mame_02499	Mame_03740	Putative FAD-linked oxidoreductase.	Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.909
cfiB	AQZ51826.1	Mame_00700	Mame_02499	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Putative FAD-linked oxidoreductase.	0.916
cfiB	ilvH	Mame_00700	Mame_02727	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Acetolactate synthase isozyme 3 small subunit.	0.808
cfiB	ilvI	Mame_00700	Mame_02726	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Acetolactate synthase isozyme 3 large subunit.	0.816
cfiB	ilvX	Mame_00700	Mame_01704	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Putative acetolactate synthase large subunit IlvX.	0.816
cfiB	ldhA	Mame_00700	Mame_04349	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.905
cfiB	leuA_1	Mame_00700	Mame_02646	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.833
cfiB	leuA_2	Mame_00700	Mame_04080	2-oxoglutarate carboxylase small subunit; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.833