(24 nodes) Protein folding, and Protein catabolic process network (Martelella mediterranea)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	dnaK_1	Heat shock protein 70. (428 aa)
	ibpA_1	16 kDa heat shock protein A; Belongs to the small heat shock protein (HSP20) family. (163 aa)
	clpB	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (867 aa)
	AQZ51024.1	Hypothetical protein. (113 aa)
	cbpA	Curved DNA-binding protein. (307 aa)
	dnaJ_1	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (381 aa)
	dnaK_2	Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. (642 aa)
	htpG	High temperature protein G. (880 aa)
	dnaJ_2	Chaperone protein DnaJ. (213 aa)
	aat	Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (205 aa)
	clpS_1	ATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (117 aa)
	clpA	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (792 aa)
	dnaJ_3	Chaperone protein DnaJ. (213 aa)
	lon_1	Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (805 aa)
	clpX	ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
	clpP_1	ATP-dependent Clp protease proteolytic subunit precursor; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (208 aa)
	lon_2	Lon protease. (357 aa)
	clpP_2	ATP-dependent Clp protease proteolytic subunit precursor; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (193 aa)
	groS	Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (98 aa)
	groL	Stress protein H5; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
	ibpA_2	16 kDa heat shock protein A; Belongs to the small heat shock protein (HSP20) family. (134 aa)
	grpE	Heat shock protein B25.3; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] (210 aa)
	hrcA	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (352 aa)
	clpS_2	ATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (103 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQZ51024.1	cbpA	Mame_01677	Mame_01678	Hypothetical protein.	Curved DNA-binding protein.	0.962
AQZ51024.1	dnaJ_1	Mame_01677	Mame_01738	Hypothetical protein.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.549
AQZ51024.1	dnaJ_2	Mame_01677	Mame_02233	Hypothetical protein.	Chaperone protein DnaJ.	0.532
AQZ51024.1	dnaJ_3	Mame_01677	Mame_03034	Hypothetical protein.	Chaperone protein DnaJ.	0.537
aat	clpA	Mame_02443	Mame_02735	Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	0.408
aat	clpS_1	Mame_02443	Mame_02734	Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.	ATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.741
aat	clpS_2	Mame_02443	Mame_04051	Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.	ATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.730
cbpA	AQZ51024.1	Mame_01678	Mame_01677	Curved DNA-binding protein.	Hypothetical protein.	0.962
cbpA	clpA	Mame_01678	Mame_02735	Curved DNA-binding protein.	ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.	0.724
cbpA	clpB	Mame_01678	Mame_01500	Curved DNA-binding protein.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.704
cbpA	clpP_1	Mame_01678	Mame_03048	Curved DNA-binding protein.	ATP-dependent Clp protease proteolytic subunit precursor; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.430
cbpA	clpP_2	Mame_01678	Mame_03807	Curved DNA-binding protein.	ATP-dependent Clp protease proteolytic subunit precursor; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.430
cbpA	dnaK_1	Mame_01678	Mame_00609	Curved DNA-binding protein.	Heat shock protein 70.	0.923
cbpA	dnaK_2	Mame_01678	Mame_01739	Curved DNA-binding protein.	Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.977
cbpA	groL	Mame_01678	Mame_03873	Curved DNA-binding protein.	Stress protein H5; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.809
cbpA	groS	Mame_01678	Mame_03872	Curved DNA-binding protein.	Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.578
cbpA	grpE	Mame_01678	Mame_03929	Curved DNA-binding protein.	Heat shock protein B25.3; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]	0.879
cbpA	hrcA	Mame_01678	Mame_03930	Curved DNA-binding protein.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.714
cbpA	htpG	Mame_01678	Mame_02201	Curved DNA-binding protein.	High temperature protein G.	0.912
cbpA	ibpA_1	Mame_01678	Mame_00988	Curved DNA-binding protein.	16 kDa heat shock protein A; Belongs to the small heat shock protein (HSP20) family.	0.408