(45 nodes) 4 iron, 4 sulfur cluster binding network (Martelella mediterranea)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	AQZ53496.1	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (115 aa)
	thiC	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (600 aa)
	AQZ49663.1	2-oxoacid ferredoxin oxidoreductase. (717 aa)
	rlmN	Dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (409 aa)
	nadA	Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (323 aa)
	ispG	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (418 aa)
	fdxA	Ferredoxin II; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (112 aa)
	nth	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (243 aa)
	mtaB	Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB. (420 aa)
	edd	Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (607 aa)
	AQZ50688.1	Putative formate dehydrogenase. (957 aa)
	hndC	NADP-reducing hydrogenase subunit HndC. (523 aa)
	ttdA	L(+)-tartrate dehydratase subunit alpha. (289 aa)
	sdhB	Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
	AQZ51493.1	Radical SAM superfamily protein. (376 aa)
	ttcA	tRNA 2-thiocytidine biosynthesis protein TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (281 aa)
	AQZ51883.1	Hypothetical protein. (217 aa)
	lipA	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
	hemN_1	Oxygen-independent coproporphyrinogen-III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (450 aa)
	AQZ52231.1	Putative oxidoreductase. (139 aa)
	sir	Sulfite reductase. (551 aa)
	hcnA_1	Hydrogen cyanide synthase subunit HcnA. (94 aa)
	nuoI	NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (163 aa)
	nqo3	NADH-quinone oxidoreductase chain 3; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (691 aa)
	nqo1	NADH-quinone oxidoreductase chain 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (432 aa)
	nuoB	NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (192 aa)
	ispH	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (329 aa)
	sufB	FeS cluster assembly protein SufB. (495 aa)
	acnA	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
	AQZ52781.1	Uracil DNA glycosylase superfamily protein. (210 aa)
	tdcG	L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa)
	AQZ52834.1	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (552 aa)
	AQZ52836.1	uracil-DNA glycosylase, family 4. (277 aa)
	kamA	L-lysine 2,3-aminomutase. (352 aa)
	yfhQ	Putative A/G-specific adenine glycosylase YfhQ; Adenine glycosylase active on G-A mispairs. (356 aa)
	rlmD	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (418 aa)
	cysH	Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (238 aa)
	lutA	Lactate utilization protein A. (433 aa)
	miaB	(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (456 aa)
	hemN_2	Oxygen-independent coproporphyrinogen-III oxidase 1; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
	moaA_1	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (345 aa)
	queG	Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (379 aa)
	moaA_2	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (342 aa)
	narG	Respiratory nitrate reductase 1 alpha chain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQZ50688.1	AQZ53496.1	Mame_01321	Mame_04201	Putative formate dehydrogenase.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.480
AQZ50688.1	hndC	Mame_01321	Mame_01322	Putative formate dehydrogenase.	NADP-reducing hydrogenase subunit HndC.	0.998
AQZ50688.1	nqo1	Mame_01321	Mame_03331	Putative formate dehydrogenase.	NADH-quinone oxidoreductase chain 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family.	0.830
AQZ50688.1	nuoI	Mame_01321	Mame_03327	Putative formate dehydrogenase.	NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.	0.839
AQZ50688.1	ttdA	Mame_01321	Mame_01831	Putative formate dehydrogenase.	L(+)-tartrate dehydratase subunit alpha.	0.800
AQZ52834.1	AQZ52836.1	Mame_03529	Mame_03531	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	uracil-DNA glycosylase, family 4.	0.541
AQZ52834.1	AQZ53496.1	Mame_03529	Mame_04201	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.535
AQZ52834.1	nuoI	Mame_03529	Mame_03327	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	NADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.	0.535
AQZ52834.1	sdhB	Mame_03529	Mame_02088	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.	0.588
AQZ52836.1	AQZ52834.1	Mame_03531	Mame_03529	uracil-DNA glycosylase, family 4.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.541
AQZ53496.1	AQZ50688.1	Mame_04201	Mame_01321	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Putative formate dehydrogenase.	0.480
AQZ53496.1	AQZ52834.1	Mame_04201	Mame_03529	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.535
AQZ53496.1	acnA	Mame_04201	Mame_04240	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.547
AQZ53496.1	hcnA_1	Mame_04201	Mame_03285	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Hydrogen cyanide synthase subunit HcnA.	0.963
AQZ53496.1	hndC	Mame_04201	Mame_01322	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	NADP-reducing hydrogenase subunit HndC.	0.939
AQZ53496.1	nqo1	Mame_04201	Mame_03331	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	NADH-quinone oxidoreductase chain 1; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family.	0.939
AQZ53496.1	nqo3	Mame_04201	Mame_03329	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	NADH-quinone oxidoreductase chain 3; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family.	0.973
AQZ53496.1	nuoB	Mame_04201	Mame_03335	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.	0.982
AQZ53496.1	sdhB	Mame_04201	Mame_02088	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Succinate dehydrogenase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.	0.820
acnA	AQZ53496.1	Mame_04240	Mame_04201	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.547