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hisG hisG hisS_1 hisS_1 ald_1 ald_1 ald_2 ald_2 hisE hisE hisF hisF hisA hisA hisH1 hisH1 hisB hisB hutU hutU AQZ50622.1 AQZ50622.1 hutH_1 hutH_1 hutI hutI AQZ50625.1 AQZ50625.1 ald_3 ald_3 hisD hisD hisC2 hisC2 hisC hisC hisI hisI
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (229 aa)
hisS_1Histidine--tRNA ligase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (379 aa)
ald_13-succinoylsemialdehyde-pyridine dehydrogenase. (478 aa)
ald_23-succinoylsemialdehyde-pyridine dehydrogenase. (474 aa)
hisEPhosphoribosyl-ATP pyrophosphatase. (107 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa)
hisH1Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisBImidazoleglycerol-phosphate dehydratase. (202 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (558 aa)
AQZ50622.1N-formylglutamate deformylase. (267 aa)
hutH_1Histidine ammonia-lyase. (511 aa)
hutIImidazolonepropionase. (404 aa)
AQZ50625.18-oxoguanine deaminase. (450 aa)
ald_33-succinoylsemialdehyde-pyridine dehydrogenase. (475 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
hisC2Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa)
hisCHistidinol-phosphate aminotransferase. (390 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (149 aa)
Your Current Organism:
Martelella mediterranea
NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316
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