(22 nodes) Methane metabolism network (Martelella mediterranea)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	acsA_1	Acetyl-coenzyme A synthetase. (519 aa)
	AQZ49957.1	Putative 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
	acsA_2	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
	fdhA	Glutathione-independent formaldehyde dehydrogenase. (398 aa)
	gpmA	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
	AQZ50687.1	NADH-dependent formate dehydrogenase delta subunit FdsD. (74 aa)
	AQZ50688.1	Putative formate dehydrogenase. (957 aa)
	hndC	NADP-reducing hydrogenase subunit HndC. (523 aa)
	hndA	NADP-reducing hydrogenase subunit HndA. (159 aa)
	lsrF	Putative aldolase LsrF. (280 aa)
	fda	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
	mdh_2	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
	ttuD	Putative hydroxypyruvate reductase. (426 aa)
	eutD	Ethanolamine utilization protein EutD. (334 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa)
	serA_2	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
	serB	Phosphoserine phosphatase. (295 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
	fghA	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (276 aa)
	flhA	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
	glyA1	Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQZ49957.1	ttuD	Mame_00574	Mame_02237	Putative 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Putative hydroxypyruvate reductase.	0.926
AQZ50687.1	AQZ50688.1	Mame_01320	Mame_01321	NADH-dependent formate dehydrogenase delta subunit FdsD.	Putative formate dehydrogenase.	0.998
AQZ50687.1	fdhA	Mame_01320	Mame_00934	NADH-dependent formate dehydrogenase delta subunit FdsD.	Glutathione-independent formaldehyde dehydrogenase.	0.911
AQZ50687.1	fghA	Mame_01320	Mame_02770	NADH-dependent formate dehydrogenase delta subunit FdsD.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.905
AQZ50687.1	hndA	Mame_01320	Mame_01323	NADH-dependent formate dehydrogenase delta subunit FdsD.	NADP-reducing hydrogenase subunit HndA.	0.996
AQZ50687.1	hndC	Mame_01320	Mame_01322	NADH-dependent formate dehydrogenase delta subunit FdsD.	NADP-reducing hydrogenase subunit HndC.	0.994
AQZ50687.1	mdh_2	Mame_01320	Mame_02091	NADH-dependent formate dehydrogenase delta subunit FdsD.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.800
AQZ50688.1	AQZ50687.1	Mame_01321	Mame_01320	Putative formate dehydrogenase.	NADH-dependent formate dehydrogenase delta subunit FdsD.	0.998
AQZ50688.1	fdhA	Mame_01321	Mame_00934	Putative formate dehydrogenase.	Glutathione-independent formaldehyde dehydrogenase.	0.903
AQZ50688.1	fghA	Mame_01321	Mame_02770	Putative formate dehydrogenase.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.907
AQZ50688.1	hndA	Mame_01321	Mame_01323	Putative formate dehydrogenase.	NADP-reducing hydrogenase subunit HndA.	0.998
AQZ50688.1	hndC	Mame_01321	Mame_01322	Putative formate dehydrogenase.	NADP-reducing hydrogenase subunit HndC.	0.998
AQZ50688.1	mdh_2	Mame_01321	Mame_02091	Putative formate dehydrogenase.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.821
ackA	acsA_1	Mame_02543	Mame_00502	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Acetyl-coenzyme A synthetase.	0.927
ackA	acsA_2	Mame_02543	Mame_00734	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.927
ackA	eutD	Mame_02543	Mame_02383	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Ethanolamine utilization protein EutD.	0.989
acsA_1	ackA	Mame_00502	Mame_02543	Acetyl-coenzyme A synthetase.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.927
acsA_1	acsA_2	Mame_00502	Mame_00734	Acetyl-coenzyme A synthetase.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.918
acsA_1	eutD	Mame_00502	Mame_02383	Acetyl-coenzyme A synthetase.	Ethanolamine utilization protein EutD.	0.915
acsA_2	ackA	Mame_00734	Mame_02543	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.927