(25 nodes) 2-Oxocarboxylic acid metabolism network (Martelella mediterranea)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	argE_1	Acetylornithine deacetylase. (385 aa)
	argE_2	Acetylornithine deacetylase. (365 aa)
	lysC	Aspartokinase; Belongs to the aspartokinase family. (416 aa)
	ilvX	Putative acetolactate synthase large subunit IlvX. (519 aa)
	AQZ51067.1	Aspartate aminotransferase. (402 aa)
	AQZ51149.1	Aspartate aminotransferase. (411 aa)
	leuD	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (371 aa)
	asd2	Aspartate-semialdehyde dehydrogenase 2; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
	ilvE	Branched-chain-amino-acid aminotransferase. (292 aa)
	argB	Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
	leuA_1	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (539 aa)
	ilvI	Acetolactate synthase isozyme 3 large subunit. (590 aa)
	ilvH	Acetolactate synthase isozyme 3 small subunit. (190 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
	gltA	Citrate synthase; Belongs to the citrate synthase family. (428 aa)
	icd	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
	argC	N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (308 aa)
	AQZ52728.1	Aspartate aminotransferase. (400 aa)
	argJ	Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (411 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (611 aa)
	leuA_2	2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (566 aa)
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
	acnA	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
	argD	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa)

Your Current Organism:

Martelella mediterranea

NCBI taxonomy Id: 1122214
Other names: M. mediterranea DSM 17316, Martelella mediterranea DSM 17316

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQZ51067.1	AQZ51149.1	Mame_01720	Mame_01805	Aspartate aminotransferase.	Aspartate aminotransferase.	0.903
AQZ51067.1	AQZ52728.1	Mame_01720	Mame_03421	Aspartate aminotransferase.	Aspartate aminotransferase.	0.904
AQZ51067.1	argJ	Mame_01720	Mame_03813	Aspartate aminotransferase.	Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.908
AQZ51067.1	asd2	Mame_01720	Mame_02242	Aspartate aminotransferase.	Aspartate-semialdehyde dehydrogenase 2; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.400
AQZ51067.1	gltA	Mame_01720	Mame_03168	Aspartate aminotransferase.	Citrate synthase; Belongs to the citrate synthase family.	0.869
AQZ51067.1	icd	Mame_01720	Mame_03311	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.831
AQZ51067.1	lysC	Mame_01720	Mame_01312	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.847
AQZ51149.1	AQZ51067.1	Mame_01805	Mame_01720	Aspartate aminotransferase.	Aspartate aminotransferase.	0.903
AQZ51149.1	AQZ52728.1	Mame_01805	Mame_03421	Aspartate aminotransferase.	Aspartate aminotransferase.	0.905
AQZ51149.1	argJ	Mame_01805	Mame_03813	Aspartate aminotransferase.	Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.908
AQZ51149.1	gltA	Mame_01805	Mame_03168	Aspartate aminotransferase.	Citrate synthase; Belongs to the citrate synthase family.	0.869
AQZ51149.1	icd	Mame_01805	Mame_03311	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.831
AQZ51149.1	lysC	Mame_01805	Mame_01312	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.847
AQZ52728.1	AQZ51067.1	Mame_03421	Mame_01720	Aspartate aminotransferase.	Aspartate aminotransferase.	0.904
AQZ52728.1	AQZ51149.1	Mame_03421	Mame_01805	Aspartate aminotransferase.	Aspartate aminotransferase.	0.905
AQZ52728.1	argJ	Mame_03421	Mame_03813	Aspartate aminotransferase.	Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.908
AQZ52728.1	asd2	Mame_03421	Mame_02242	Aspartate aminotransferase.	Aspartate-semialdehyde dehydrogenase 2; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.410
AQZ52728.1	gltA	Mame_03421	Mame_03168	Aspartate aminotransferase.	Citrate synthase; Belongs to the citrate synthase family.	0.869
AQZ52728.1	icd	Mame_03421	Mame_03311	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.831
AQZ52728.1	lysC	Mame_03421	Mame_01312	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.847