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gshA | Glutamate--cysteine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (546 aa) | ||||
thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (272 aa) | ||||
OJA03954.1 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (185 aa) | ||||
OJA04016.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa) | ||||
OJA04023.1 | Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa) | ||||
OJA04055.1 | Derived by automated computational analysis using gene prediction method: Protein Homology. (876 aa) | ||||
argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa) | ||||
OJA04129.1 | Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa) | ||||
OJA04130.1 | Agmatine deiminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the agmatine deiminase family. (353 aa) | ||||
OJA04192.1 | Cysteine synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (302 aa) | ||||
argG | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) | ||||
serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa) | ||||
gcvP | Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (964 aa) | ||||
gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) | ||||
gcvT | Glycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa) | ||||
folD | Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) | ||||
OJA04476.1 | Amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa) | ||||
ectA | Diaminobutyrate acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (192 aa) | ||||
OJA04514.1 | Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) | ||||
ectC | L-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (129 aa) | ||||
OJA04527.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1231 aa) | ||||
cysS | cysteine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (471 aa) | ||||
OJA04678.1 | L-asparaginase 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa) | ||||
OJA04690.1 | Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (596 aa) | ||||
purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) | ||||
metN | DL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (352 aa) | ||||
OJA07337.1 | Methionine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa) | ||||
OJA04711.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa) | ||||
OJA04712.1 | Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa) | ||||
OJA04724.1 | Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa) | ||||
metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa) | ||||
asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) | ||||
proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (435 aa) | ||||
glsA | Glutaminase; Catalyzes the formation of glutamate from glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (306 aa) | ||||
OJA04898.1 | Bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1063 aa) | ||||
OJA04976.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (311 aa) | ||||
OJA05115.1 | Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (348 aa) | ||||
OJA05174.1 | Dihydrodipicolinate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (297 aa) | ||||
OJA05216.1 | 3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa) | ||||
argD | Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) | ||||
OJA05340.1 | L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) | ||||
speD | S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa) | ||||
OJA05364.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (366 aa) | ||||
OJA05400.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa) | ||||
OJA05401.1 | NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (498 aa) | ||||
OJA05402.1 | AsnC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa) | ||||
OJA05403.1 | N-alpha-acetyl diaminobutyric acid deacetylase DoeB; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa) | ||||
OJA05404.1 | Ectoine hydrolase DoeA; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa) | ||||
dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) | ||||
metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (765 aa) | ||||
OJA05568.1 | Cytosol nonspecific dipeptidase; Catalyzes the hydrolysis of Xaa-His dipeptides; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa) | ||||
thrB | Homoserine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudomonas-type ThrB family. (319 aa) | ||||
speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (638 aa) | ||||
OJA05579.1 | Ectoine hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa) | ||||
OJA05657.1 | Xyl repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa) | ||||
OJA05681.1 | Agmatinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (316 aa) | ||||
OJA05782.1 | D-amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa) | ||||
OJA05789.1 | GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa) | ||||
OJA07404.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) | ||||
OJA05790.1 | NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa) | ||||
OJA07408.1 | Agmatinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (300 aa) | ||||
OJA05818.1 | O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa) | ||||
OJA05832.1 | Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa) | ||||
OJA05834.1 | Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa) | ||||
OJA05862.1 | O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa) | ||||
OJA05867.1 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa) | ||||
OJA05947.1 | Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa) | ||||
OJA05954.1 | D-3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (414 aa) | ||||
speE | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (288 aa) | ||||
OJA05971.1 | Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa) | ||||
OJA05997.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (647 aa) | ||||
argH | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa) | ||||
argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) | ||||
OJA06246.1 | 5-formyltetrahydrofolate cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa) | ||||
OJA06406.1 | Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa) | ||||
OJA06422.1 | Acetylornithine deacetylase (ArgE); Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa) | ||||
proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (379 aa) | ||||
dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa) | ||||
OJA07453.1 | Methionine biosynthesis protein MetW; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa) | ||||
metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (408 aa) | ||||
proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) | ||||
metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (406 aa) | ||||
OJA06533.1 | Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (280 aa) | ||||
OJA06557.1 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa) | ||||
OJA06561.1 | AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa) | ||||
OJA06562.1 | Peptidase M19; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa) | ||||
OJA06563.1 | Hydrocarbon binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa) | ||||
OJA06564.1 | N-methylproline demethylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (698 aa) | ||||
OJA06565.1 | (Fe-S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (667 aa) | ||||
OJA06576.1 | N-methylproline demethylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa) | ||||
OJA06578.1 | Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa) | ||||
OJA07457.1 | Hybrid-cluster NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa) | ||||
glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa) | ||||
OJA06580.1 | Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa) | ||||
OJA06581.1 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa) | ||||
OJA06582.1 | Sarcosine oxidase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (1016 aa) | ||||
OJA06583.1 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa) | ||||
purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) | ||||
OJA06585.1 | L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa) | ||||
OJA06595.1 | Disulfide bond formation protein DsbA; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa) | ||||
OJA06639.1 | Homoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa) | ||||
OJA06640.1 | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa) | ||||
argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) | ||||
OJA06670.1 | Alanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AlaDH/PNT family. (372 aa) | ||||
OJA06673.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa) | ||||
dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (390 aa) | ||||
dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (341 aa) | ||||
OJA06677.1 | Succinyldiaminopimelate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa) | ||||
pepA | Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (506 aa) | ||||
OJA06747.1 | Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa) | ||||
OJA06784.1 | Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa) | ||||
OJA06817.1 | Homoserine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (397 aa) | ||||
OJA06841.1 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1480 aa) | ||||
OJA06842.1 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa) | ||||
OJA06852.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (416 aa) | ||||
argA | Amino-acid N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily. (437 aa) | ||||
OJA06951.1 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa) | ||||
OJA06952.1 | Amino acid oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa) | ||||
OJA06953.1 | Spermidine acetyltransferase; Catalyzes the formation of N(1)- and N(8)-acetylspermidine from spermidine; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa) | ||||
OJA07012.1 | Class V aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa) | ||||
OJA07086.1 | Aspartate/glutamate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa) | ||||
murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (278 aa) | ||||
OJA07202.1 | Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa) | ||||
OJA07205.1 | Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa) | ||||
glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa) |