(50 nodes) Latent infection - Other responses of Mtb to phagocytosis network (Halomonas sp. QHL1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OJA05993.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (606 aa)
	secA	Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (910 aa)
	msbA	Lipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (578 aa)
	QHL1GM_01440	Electron transfer flavoprotein subunit beta; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (203 aa)
	OJA07300.1	Cyanoglobin; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
	OJA07302.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
	OJA04347.1	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (428 aa)
	msrA	Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (210 aa)
	OJA04573.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
	OJA04594.1	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily. (527 aa)
	OJA04620.1	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
	OJA04791.1	Nickel/dipeptide/oligopeptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
	OJA04792.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
	OJA04793.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
	OJA05019.1	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family. (107 aa)
	OJA05057.1	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
	OJA05223.1	Alkylhydroperoxidase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (193 aa)
	OJA05268.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
	msrA-2	Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (212 aa)
	OJA05316.1	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
	OJA05337.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
	OJA05393.1	Peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	OJA05497.1	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (678 aa)
	OJA05506.1	Peroxiredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
	OJA05609.1	Thioredoxin-disulfide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
	katG	Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (717 aa)
	OJA05814.1	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
	OJA06011.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
	secE	Preprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. (127 aa)
	secY	Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
	OJA06489.1	Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (119 aa)
	OJA06558.1	Co-chaperone YbbN; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
	OJA06725.1	Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (160 aa)
	OJA06727.1	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (178 aa)
	secF	Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (308 aa)
	secD	Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (617 aa)
	OJA06803.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
	OJA06804.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	OJA06805.1	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (518 aa)
	OJA06881.1	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
	OJA06948.1	NADPH-dependent ferric siderophore reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
	OJA06980.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
	OJA06987.1	Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	tpx	Lipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (166 aa)
	OJA07141.1	Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (523 aa)
	OJA07166.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
	OJA07167.1	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	OJA07168.1	Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
	OJA07199.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
	OJA03880.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (125 aa)

Your Current Organism:

Halomonas sp. QHL1

NCBI taxonomy Id: 1123773
Other names: H. sp. QHL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OJA03880.1	OJA06948.1	QHL1GM_18785	QHL1GM_16905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	NADPH-dependent ferric siderophore reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.444
OJA04347.1	OJA05019.1	QHL1GM_02475	QHL1GM_06225	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.	0.418
OJA04347.1	OJA05497.1	QHL1GM_02475	QHL1GM_08875	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.799
OJA04347.1	OJA06558.1	QHL1GM_02475	QHL1GM_14810	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Co-chaperone YbbN; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.418
OJA04594.1	OJA04791.1	QHL1GM_03885	QHL1GM_04985	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Nickel/dipeptide/oligopeptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.695
OJA04594.1	OJA04792.1	QHL1GM_03885	QHL1GM_04990	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.923
OJA04594.1	OJA04793.1	QHL1GM_03885	QHL1GM_04995	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
OJA04594.1	OJA06803.1	QHL1GM_03885	QHL1GM_16105	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
OJA04594.1	OJA06804.1	QHL1GM_03885	QHL1GM_16110	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
OJA04594.1	OJA06805.1	QHL1GM_03885	QHL1GM_16115	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
OJA04594.1	OJA07166.1	QHL1GM_03885	QHL1GM_18090	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.927
OJA04594.1	OJA07167.1	QHL1GM_03885	QHL1GM_18095	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.894
OJA04594.1	OJA07168.1	QHL1GM_03885	QHL1GM_18100	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Nickel ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.784
OJA04594.1	OJA07199.1	QHL1GM_03885	QHL1GM_18255	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.581
OJA04620.1	OJA05019.1	QHL1GM_04025	QHL1GM_06225	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.	0.418
OJA04620.1	OJA05497.1	QHL1GM_04025	QHL1GM_08875	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.903
OJA04620.1	OJA06558.1	QHL1GM_04025	QHL1GM_14810	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Co-chaperone YbbN; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.418
OJA04791.1	OJA04594.1	QHL1GM_04985	QHL1GM_03885	Nickel/dipeptide/oligopeptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Microcin ABC transporter ATP-binding protein; With YejAEF is involved in resistance to microcin C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.695
OJA04791.1	OJA04792.1	QHL1GM_04985	QHL1GM_04990	Nickel/dipeptide/oligopeptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
OJA04791.1	OJA04793.1	QHL1GM_04985	QHL1GM_04995	Nickel/dipeptide/oligopeptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990