STRINGSTRING
AEW61809.1 AEW61809.1 AEW61853.1 AEW61853.1 hisC hisC aroC aroC AEW62688.1 AEW62688.1 aroE-2 aroE-2 AEW62690.1 AEW62690.1 aroQ aroQ AEW63485.1 AEW63485.1 AEW62691.1 AEW62691.1 AEW58933.1 AEW58933.1 AEW58976.1 AEW58976.1 aroD aroD aroE aroE aroK aroK AEW59825.1 AEW59825.1 aroB aroB AEW60288.1 AEW60288.1 AEW60360.1 AEW60360.1 aroA aroA aroK-2 aroK-2 AEW60534.1 AEW60534.1 AEW60662.1 AEW60662.1 trpA trpA trpB trpB trpF trpF trpD trpD AEW60861.1 AEW60861.1 AEW61037.1 AEW61037.1 AEW61627.1 AEW61627.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEW61809.1Shikimate 5-dehydrogenase. (278 aa)
AEW61853.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (380 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
AEW62688.1Bifunctional chorismate mutase/prephenate dehydratase. (386 aa)
aroE-2Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
AEW62690.1Bifunctional chorismate mutase/prephenate dehydrogenase. (373 aa)
aroQType II 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
AEW63485.1Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (193 aa)
AEW62691.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
AEW58933.1Shikimate 5-dehydrogenase. (269 aa)
AEW58976.1Aromatic amino acid aminotransferase. (397 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (251 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa)
aroKShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa)
AEW59825.1Shikimate/quinate 5-dehydrogenase. (273 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (327 aa)
AEW60288.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa)
AEW60360.1Hypothetical protein. (322 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
aroK-2Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa)
AEW60534.1Aromatic amino acid aminotransferase. (396 aa)
AEW60662.1Putative inhibitor of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (194 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpFBifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Belongs to the TrpC family. (452 aa)
trpDBifunctional anthranilate synthase/anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
AEW60861.1Anthranilate synthase component I. (520 aa)
AEW61037.1Aromatic amino acid aminotransferase. (399 aa)
AEW61627.1Glucose dehydrogenase. (790 aa)
Your Current Organism:
Klebsiella pneumoniae HS11286
NCBI taxonomy Id: 1125630
Other names: K. pneumoniae subsp. pneumoniae HS11286, Klebsiella pneumoniae subsp. pneumoniae HS11286, Klebsiella pneumoniae subsp. pneumoniae str. HS11286, Klebsiella pneumoniae subsp. pneumoniae strain HS11286
Server load: low (24%) [HD]