(24 nodes) Pantothenate and CoA biosynthesis network (Paenibacillus beijingensis)

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Your Input:
	coaE	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
	AJY73692.1	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
	AJY73693.1	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
	AJY73758.1	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
	AJY73759.1	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
	AJY73760.1	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
	acpS	4'-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (136 aa)
	AJY77629.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
	coaX	Transcriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa)
	AJY75465.1	Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
	AJY75905.1	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (585 aa)
	AJY76021.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
	ilvD	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (556 aa)
	AJY76133.1	Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (313 aa)
	AJY77850.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the P-Pant transferase superfamily. (210 aa)
	AJY76355.1	Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (331 aa)
	AJY76455.1	Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa)
	coaD	Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
	AJY76715.1	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
	AJY76758.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (558 aa)
	panD	L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
	panC	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (307 aa)
	panB	3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (284 aa)

Your Current Organism:

Paenibacillus beijingensis

NCBI taxonomy Id: 1126833
Other names: ACCC 03082, DSM 24997, P. beijingensis, Paenibacillus sp. 7188, strain 7188

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJY73692.1	AJY73693.1	VN24_02400	VN24_02405	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJY73692.1	AJY75465.1	VN24_02400	VN24_13915	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
AJY73692.1	AJY75905.1	VN24_02400	VN24_16800	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.880
AJY73692.1	AJY76021.1	VN24_02400	VN24_17490	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJY73692.1	AJY76758.1	VN24_02400	VN24_22045	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.998
AJY73692.1	ilvC	VN24_02400	VN24_02395	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.998
AJY73692.1	ilvD	VN24_02400	VN24_18100	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.885
AJY73693.1	AJY73692.1	VN24_02405	VN24_02400	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJY73693.1	AJY75465.1	VN24_02405	VN24_13915	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
AJY73693.1	AJY75905.1	VN24_02405	VN24_16800	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.927
AJY73693.1	AJY76021.1	VN24_02405	VN24_17490	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
AJY73693.1	AJY76758.1	VN24_02405	VN24_22045	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.925
AJY73693.1	ilvC	VN24_02405	VN24_02395	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.998
AJY73693.1	ilvD	VN24_02405	VN24_18100	Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.	0.954
AJY73758.1	AJY73759.1	VN24_02825	VN24_02830	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
AJY73758.1	AJY73760.1	VN24_02825	VN24_02835	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
AJY73758.1	AJY76715.1	VN24_02825	VN24_21770	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AJY73758.1	AJY77629.1	VN24_02825	VN24_09585	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
AJY73759.1	AJY73758.1	VN24_02830	VN24_02825	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
AJY73759.1	AJY73760.1	VN24_02830	VN24_02835	Dihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999