STRINGSTRING
rpiB rpiB CCF62139.1 CCF62139.1 CCF62188.1 CCF62188.1 rbsK rbsK CCF62615.1 CCF62615.1 pykA pykA gap gap CCF63560.1 CCF63560.1 cbbF cbbF tkt tkt tal tal tpiA tpiA pgk pgk gap-2 gap-2 rpe rpe ppgK ppgK pfkA pfkA glpX glpX eno eno prsA prsA pgi pgi CCF65745.1 CCF65745.1 deoC deoC fbaA fbaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpiBRibose-5-phosphate isomerase B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (157 aa)
CCF62139.1Putative sugar kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (297 aa)
CCF62188.1Phosphoketolase; Function of strongly homologous gene; enzyme. (824 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (289 aa)
CCF62615.1Sugar kinase; Function of strongly homologous gene; enzyme. (336 aa)
pykAPyruvate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (444 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase 2; Function of strongly homologous gene; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (487 aa)
CCF63560.1Conserved protein of unknown function, putative Ribokinase domain; Homologs of previously reported genes of unknown function. (493 aa)
cbbFFructose-1,6-bisphosphatase, (D-fructose-1, 6-bisphosphate 1-phosphohydrolase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FBPase class 1 family. (350 aa)
tktTkt transketolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transketolase family. (713 aa)
talTal, transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (378 aa)
tpiAtpiA Triosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkPhosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (406 aa)
gap-2Glyceraldehyde-3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
rpeRibulose-phosphate 3-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
ppgKPolyphosphate glucokinase (Polyphosphate--glucose phosphotransferase); Function of strongly homologous gene; enzyme. (252 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (327 aa)
glpXFructose 1,6-bisphosphatase II; Function of strongly homologous gene; enzyme. (347 aa)
enoEnolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
pgiGlucosephosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GPI family. (550 aa)
CCF65745.1Putative sugar kinase, Glucokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (298 aa)
deoCDeoxyribose-phosphate aldolase (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (222 aa)
fbaAFructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
Your Current Organism:
Nocardia cyriacigeorgica
NCBI taxonomy Id: 1127134
Other names: N. cyriacigeorgica GUH-2, Nocardia cyriacigeorgica GUH-2, Nocardia cyriacigeorgica str. GUH-2, Nocardia cyriacigeorgica strain GUH-2
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.