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| | thiL | Putative thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | ascA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa) |
| | mshD | Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (306 aa) |
| | CCF61495.1 | acyl-CoA synthetase; Function of strongly homologous gene; enzyme. (690 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (269 aa) |
| | CCF61695.1 | Homologs of previously reported genes of unknown function. (547 aa) |
| | metX | Homoserine O-acetyltransferase (Homoserine O-trans-acetylase) (Homoserine transacetylase) (HTA); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa) |
| | metC | O-acetylhomoserine aminocarboxypropyltransferase; Function of strongly homologous gene; enzyme. (441 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; Function of strongly homologous gene; enzyme. (372 aa) |
| | thrA | Homoserine dehydrogenase; Function of strongly homologous gene; enzyme. (456 aa) |
| | CCF61975.1 | Homologs of previously reported genes of unknown function. (140 aa) |
| | CCF61976.1 | Molybdopterin synthase/thiamin biosynthesis sulphur carrier; Function of strongly homologous gene; carrier. (90 aa) |
| | cysM | Cysteine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (320 aa) |
| | CCF62099.1 | Cysteine synthase; Function of strongly homologous gene; enzyme. (398 aa) |
| | CCF62180.1 | Homologs of previously reported genes of unknown function. (125 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (309 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (239 aa) |
| | CCF62313.1 | Putative transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (202 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (306 aa) |
| | CCF62679.1 | Homologs of previously reported genes of unknown function. (155 aa) |
| | acsA | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | bioA | Adenosylmethionine 8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (422 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (377 aa) |
| | bioD | Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | CCF62892.1 | Homologs of previously reported genes of unknown function. (152 aa) |
| | CCF62973.1 | Homologs of previously reported genes of unknown function. (404 aa) |
| | CCF63112.1 | Homologs of previously reported genes of unknown function. (415 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | cysNC | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. (610 aa) |
| | cysD-2 | Sulfate adenylyltransferase subunit 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (310 aa) |
| | cysS-2 | cysteinyl-tRNA synthetase 2 (Cysteine--tRNA ligase 2) (CysRS 2); Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (394 aa) |
| | CCF63746.1 | Prophage Lp1 protein 5 (modular protein); Function of strongly homologous gene; structure. (201 aa) |
| | CCF63831.1 | ThiamineS protein; Function of strongly homologous gene; enzyme. (90 aa) |
| | cobG | Precorrin-3B synthase; Function of strongly homologous gene; enzyme. (381 aa) |
| | metH | 5-methyltetrahydrofolate:homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1198 aa) |
| | CCF64247.1 | Putative gamma-glutamyltranspeptidase ggt; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (636 aa) |
| | metK | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (403 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | bioA2 | Transaminase; Function of strongly homologous gene; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (407 aa) |
| | CCF64629.1 | Putative acyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (541 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (737 aa) |
| | CCF64760.1 | Putative methionine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (346 aa) |
| | CCF64790.1 | Putative pyridoxal-phosphate dependent amino-acid synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (375 aa) |
| | metC-2 | O-acetylhomoserine aminocarboxypropyltransferase; Function of strongly homologous gene; enzyme. (441 aa) |
| | metK-2 | S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (405 aa) |
| | moeB | Molybdopterin synthase sulfurylase; Function of strongly homologous gene; enzyme. (394 aa) |
| | CCF65117.1 | Putative acetyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (239 aa) |
| | mshB | N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (297 aa) |
| | CCF65298.1 | Homologs of previously reported genes of unknown function. (136 aa) |
| | metB | Cystathionine gamma-synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (380 aa) |
| | cbs | Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (463 aa) |
| | CCF65413.1 | Putative cysteine synthase (O-acetylserine sulfhydrylase) (CSase) (O-acetylserine (Thiol)-lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (344 aa) |
| | egtD | Conserved protein of unknown function; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (323 aa) |
| | CCF65426.1 | Homologs of previously reported genes of unknown function. (271 aa) |
| | egtB | Conserved protein of unknown function; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (447 aa) |
| | egtA | Putative glutamylcysteine synthetase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (437 aa) |
| | CCF65577.1 | Acetoacetyl-coenzyme A synthetase (Acetoacetate--CoA ligase 1) (Acyl-activating enzyme 1); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (647 aa) |
| | CCF65705.1 | Putative cysteine synthase (O-acetylserine sulfhydrylase) (CSase) (O-acetylserine (Thiol)-lyase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (361 aa) |
| | mshA | Uncharacterized glycosyltransferase Mb0496; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (440 aa) |
| | metE-2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (779 aa) |
| | CCF65828.1 | Homologs of previously reported genes of unknown function. (125 aa) |
| | thiC | Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (553 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (239 aa) |
| | thiG | Thiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (258 aa) |
| | CCF65933.1 | Putative sulfur transfer protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (72 aa) |
| | CCF65934.1 | Putative thiamine biosynthesis oxidoreductase thiO; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (364 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa) |
| | ackA | Acetate kinase (Acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (690 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (404 aa) |
