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purK purK purE purE gppA gppA C427_0262 C427_0262 C427_0323 C427_0323 gmk gmk C427_0337 C427_0337 C427_0434 C427_0434 C427_0486 C427_0486 C427_0488 C427_0488 C427_0560 C427_0560 C427_0734 C427_0734 C427_0862 C427_0862 C427_0863 C427_0863 apaH apaH C427_1518 C427_1518 C427_1549 C427_1549 C427_1661 C427_1661 apt apt adk adk C427_1849 C427_1849 cysN cysN cysC cysC cysD cysD C427_1997 C427_1997 C427_1998 C427_1998 add add purN purN C427_2508 C427_2508 purC purC nrdB nrdB C427_2525 C427_2525 C427_2817 C427_2817 allA allA C427_3025 C427_3025 C427_3032 C427_3032 C427_3034 C427_3034 C427_3035 C427_3035 C427_3037 C427_3037 C427_3038 C427_3038 C427_3039 C427_3039 C427_3209 C427_3209 prs prs purF purF ppnP ppnP purL purL guaA guaA guaB guaB ndk ndk C427_4557 C427_4557 C427_4927 C427_4927 C427_5031 C427_5031 purA purA C427_5471 C427_5471 C427_5472 C427_5472 purD purD purH purH ureA ureA ureB ureB ureC ureC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (366 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
gppAPpx/GppA phosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (505 aa)
C427_0262Adenosine deaminase. (490 aa)
C427_0323(p)ppGpp synthetase I SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (704 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (214 aa)
C427_03373',5'-cyclic-nucleotide phosphodiesterase. (350 aa)
C427_0434Adenylate/guanylate cyclase. (363 aa)
C427_0486Hypothetical protein. (250 aa)
C427_0488Nucleoside diphosphate pyrophosphatase. (211 aa)
C427_0560NTPase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (176 aa)
C427_0734Hypothetical protein; Belongs to the 5'-nucleotidase family. (479 aa)
C427_0862(p)ppGpp synthetase SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (718 aa)
C427_0863MazG family protein. (269 aa)
apaHDiadenosine tetraphosphatase. (270 aa)
C427_1518Ppx/GppA phosphatase; Belongs to the GppA/Ppx family. (513 aa)
C427_1549Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
C427_1661Hypothetical protein. (452 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (178 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
C427_1849Hypothetical protein. (267 aa)
cysNSulfate adenylyltransferase large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (468 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (198 aa)
cysDSulfate adenylyltransferase small subunit. (304 aa)
C427_1997Hypothetical protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (420 aa)
C427_1998Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (460 aa)
addAdenosine deaminase. (326 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (221 aa)
C427_2508Phosphoribosylformylglycinamidine cyclo-ligase. (262 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (367 aa)
nrdBRibonucleotide-diphosphate reductase subunit beta. (376 aa)
C427_2525Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (771 aa)
C427_2817Deoxyguanosinetriphosphate triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (443 aa)
allAUreidoglycolate hydrolase. (167 aa)
C427_3025Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (335 aa)
C427_3032Polysaccharide deacetylase. (300 aa)
C427_3034Molybdopterin dehydrogenase. (492 aa)
C427_3035Xanthine dehydrogenase, molybdopterin binding subunit. (780 aa)
C427_3037Uricase-like protein. (183 aa)
C427_3038Transthyretin; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (108 aa)
C427_3039Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (438 aa)
C427_3209Phosphoglucomutase. (550 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa)
guaAGMP synthase. (421 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
C427_4557Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
C427_4927Hypothetical protein. (278 aa)
C427_5031Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (335 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (446 aa)
C427_5471NUDIX hydrolase. (187 aa)
C427_5472HAD-superfamily hydrolase. (227 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (428 aa)
purHBifunctionalphosphoribosylaminoimidazolecarboxam ide formyltransferase/IMP cyclohydrolase. (484 aa)
ureAUrease subunit gamma; Belongs to the urease gamma subunit family. (100 aa)
ureBUrease subunit beta; Belongs to the urease beta subunit family. (101 aa)
ureCUrease subunit alpha. (567 aa)
Your Current Organism:
Paraglaciecola psychrophila
NCBI taxonomy Id: 1129794
Other names: Glaciecola psychrophila 170, Glaciecola psychrophila str. 170, Glaciecola psychrophila strain 170, P. psychrophila 170, Paraglaciecola psychrophila 170
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